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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Peregrin (Homo sapiens (Human)) | BDBM50157570 (4-cyano-N-(1,3-dimethyl-2-oxoquinolin-6-yl)-2-meth...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet  | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
UCL School of Pharmacy, University College London , 29/39 Brunswick Square, London WC1N 1AX, U.K. Curated by ChEMBL | Assay Description Inhibition of BAZ2A (unknown origin) after 30 mins by AlphaScreen assay | J Med Chem 60: 6998-7011 (2017) Article DOI: 10.1021/acs.jmedchem.7b00611 BindingDB Entry DOI: 10.7270/Q2P55QZP | |||||||||||
| More data for this Ligand-Target Pair |  3D Structure (crystal) | ||||||||||||
| Peregrin (Homo sapiens (Human)) | BDBM50157570 (4-cyano-N-(1,3-dimethyl-2-oxoquinolin-6-yl)-2-meth...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 114 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Oxford University | Assay Description Assays were performed as described previously with minor modifications(Philpott et al., 2011). All reagents were diluted in 25 mM HEPES, 100 mM NaCl,... | ACS Chem Biol 12: 2619-2630 (2017) Article DOI: 10.1021/acschembio.7b00481 BindingDB Entry DOI: 10.7270/Q2HM56MX | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Bromodomain-containing protein 1 (Homo sapiens (Human)) | BDBM50157570 (4-cyano-N-(1,3-dimethyl-2-oxoquinolin-6-yl)-2-meth...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 315 | n/a | n/a | n/a | n/a | n/a | n/a |
UCL School of Pharmacy, University College London , 29/39 Brunswick Square, London WC1N 1AX, U.K. Curated by ChEMBL | Assay Description Displacement of H3K14Ac from BAZ2B (unknown origin) preincubated for 30 mins with non-biotinylated peptide followed by addition of biotinylated pepti... | J Med Chem 60: 6998-7011 (2017) Article DOI: 10.1021/acs.jmedchem.7b00611 BindingDB Entry DOI: 10.7270/Q2P55QZP | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bromodomain-containing protein 1 (Homo sapiens (Human)) | BDBM50157570 (4-cyano-N-(1,3-dimethyl-2-oxoquinolin-6-yl)-2-meth...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 619 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Oxford University | Assay Description Assays were performed as described previously with minor modifications(Philpott et al., 2011). All reagents were diluted in 25 mM HEPES, 100 mM NaCl,... | ACS Chem Biol 12: 2619-2630 (2017) Article DOI: 10.1021/acschembio.7b00481 BindingDB Entry DOI: 10.7270/Q2HM56MX | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bromodomain-containing protein 9 [133-239] (Homo sapiens (Human)) | BDBM50157570 (4-cyano-N-(1,3-dimethyl-2-oxoquinolin-6-yl)-2-meth...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bromodomain and PHD finger-containing protein 3 (Homo sapiens (Human)) | BDBM50157570 (4-cyano-N-(1,3-dimethyl-2-oxoquinolin-6-yl)-2-meth...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.01E+3 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Oxford University | Assay Description Assays were performed as described previously with minor modifications(Philpott et al., 2011). All reagents were diluted in 25 mM HEPES, 100 mM NaCl,... | ACS Chem Biol 12: 2619-2630 (2017) Article DOI: 10.1021/acschembio.7b00481 BindingDB Entry DOI: 10.7270/Q2HM56MX | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bromodomain and PHD finger-containing protein 3 (Homo sapiens (Human)) | BDBM50157570 (4-cyano-N-(1,3-dimethyl-2-oxoquinolin-6-yl)-2-meth...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UCL School of Pharmacy, University College London , 29/39 Brunswick Square, London WC1N 1AX, U.K. Curated by ChEMBL | Assay Description Inhibition of BAZ2A (unknown origin) after 30 mins by AlphaScreen assay | J Med Chem 60: 6998-7011 (2017) Article DOI: 10.1021/acs.jmedchem.7b00611 BindingDB Entry DOI: 10.7270/Q2P55QZP | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bromodomain-containing protein 9 (Homo sapiens (Human)) | BDBM50157570 (4-cyano-N-(1,3-dimethyl-2-oxoquinolin-6-yl)-2-meth...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 4.38E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UCL School of Pharmacy, University College London , 29/39 Brunswick Square, London WC1N 1AX, U.K. Curated by ChEMBL | Assay Description Inhibition of BAZ2A (unknown origin) after 30 mins by AlphaScreen assay | J Med Chem 60: 6998-7011 (2017) Article DOI: 10.1021/acs.jmedchem.7b00611 BindingDB Entry DOI: 10.7270/Q2P55QZP | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bromodomain-containing protein 4 (Homo sapiens (Human)) | BDBM50157570 (4-cyano-N-(1,3-dimethyl-2-oxoquinolin-6-yl)-2-meth...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Oxford University | Assay Description Assays were performed as described previously with minor modifications(Philpott et al., 2011). All reagents were diluted in 25 mM HEPES, 100 mM NaCl,... | ACS Chem Biol 12: 2619-2630 (2017) Article DOI: 10.1021/acschembio.7b00481 BindingDB Entry DOI: 10.7270/Q2HM56MX | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Transcription intermediary factor 1-alpha (Homo sapiens (Human)) | BDBM50157570 (4-cyano-N-(1,3-dimethyl-2-oxoquinolin-6-yl)-2-meth...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Oxford University | Assay Description Assays were performed as described previously with minor modifications(Philpott et al., 2011). All reagents were diluted in 25 mM HEPES, 100 mM NaCl,... | ACS Chem Biol 12: 2619-2630 (2017) Article DOI: 10.1021/acschembio.7b00481 BindingDB Entry DOI: 10.7270/Q2HM56MX | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
