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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50171976 (4-[2-(5-Ethyl-7-fluoro-10-methyl-11-oxo-10,11-dihy...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet  | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 15 | n/a | n/a | n/a | n/a | 7.8 | n/a |
Boehringer Ingelheim (Canada) Ltd. Curated by ChEMBL | Assay Description Inhibitory activity of compound dissolved in DMSO was determined against HIV-1 wild type reverse transcriptase (1-2 nM) by using [3H]-dGTP (71 nM) a... | J Med Chem 48: 5580-8 (2005) Article DOI: 10.1021/jm050255t BindingDB Entry DOI: 10.7270/Q29K49RC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50171976 (4-[2-(5-Ethyl-7-fluoro-10-methyl-11-oxo-10,11-dihy...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 150 | n/a | n/a | n/a | n/a | 7.8 | n/a |
Boehringer Ingelheim (Canada) Ltd. Curated by ChEMBL | Assay Description Inhibitory activity of compound dissolved in DMSO was determined against HIV-1 (K103N/Y181C) mutant reverse transcriptase (1-2 nM) by using [3H]-dGTP... | J Med Chem 48: 5580-8 (2005) Article DOI: 10.1021/jm050255t BindingDB Entry DOI: 10.7270/Q29K49RC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cytochrome P450 2C19 (Homo sapiens (Human)) | BDBM50171976 (4-[2-(5-Ethyl-7-fluoro-10-methyl-11-oxo-10,11-dihy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim (Canada) Ltd. Curated by ChEMBL | Assay Description Inhibitory concentration (1.5 mM) against human CYP450 2C19 dissolved in acetonitrile/methanol | J Med Chem 48: 5580-8 (2005) Article DOI: 10.1021/jm050255t BindingDB Entry DOI: 10.7270/Q29K49RC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cytochrome P450 2C9 (Homo sapiens (Human)) | BDBM50171976 (4-[2-(5-Ethyl-7-fluoro-10-methyl-11-oxo-10,11-dihy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim (Canada) Ltd. Curated by ChEMBL | Assay Description Inhibitory concentration (1.5 mM) against human CYP450 2C9 dissolved in acetonitrile/methanol | J Med Chem 48: 5580-8 (2005) Article DOI: 10.1021/jm050255t BindingDB Entry DOI: 10.7270/Q29K49RC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cytochrome P450 3A4 (Homo sapiens (Human)) | BDBM50171976 (4-[2-(5-Ethyl-7-fluoro-10-methyl-11-oxo-10,11-dihy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim (Canada) Ltd. Curated by ChEMBL | Assay Description Inhibitory concentration (1.5 mM) against human CYP450 3A4 dissolved in acetonitrile/methanol using 7-Benzyloxy-4-(trifluoromethyl)coumarin (BFC) as ... | J Med Chem 48: 5580-8 (2005) Article DOI: 10.1021/jm050255t BindingDB Entry DOI: 10.7270/Q29K49RC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cytochrome P450 1A2 (Homo sapiens (Human)) | BDBM50171976 (4-[2-(5-Ethyl-7-fluoro-10-methyl-11-oxo-10,11-dihy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim (Canada) Ltd. Curated by ChEMBL | Assay Description Inhibitory concentration (1.5 mM) against human CYP450 1A2 dissolved in acetonitrile/methanol | J Med Chem 48: 5580-8 (2005) Article DOI: 10.1021/jm050255t BindingDB Entry DOI: 10.7270/Q29K49RC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cytochrome P450 2D6 (Homo sapiens (Human)) | BDBM50171976 (4-[2-(5-Ethyl-7-fluoro-10-methyl-11-oxo-10,11-dihy...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim (Canada) Ltd. Curated by ChEMBL | Assay Description Inhibitory concentration (1.5 mM) against human CYP450 2D6 dissolved in acetonitrile/methanol | J Med Chem 48: 5580-8 (2005) Article DOI: 10.1021/jm050255t BindingDB Entry DOI: 10.7270/Q29K49RC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cytochrome P450 3A4 (Homo sapiens (Human)) | BDBM50171976 (4-[2-(5-Ethyl-7-fluoro-10-methyl-11-oxo-10,11-dihy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim (Canada) Ltd. Curated by ChEMBL | Assay Description Inhibitory concentration (1.5 mM) against human CYP450 3A4 dissolved in acetonitrile/methanol using 7-Benzyloxy-quinoline (BQ) as fluorogenic substra... | J Med Chem 48: 5580-8 (2005) Article DOI: 10.1021/jm050255t BindingDB Entry DOI: 10.7270/Q29K49RC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
