Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta-adrenergic receptor kinase 1 (Bos taurus) | BDBM50173319 (CHEMBL3809020 | US10023564, Example 11) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Medicinal Chemistry, College of Pharmacy,?Departments of Pharmacology and Biological Chemistry, Life Sciences Institute,§Ph.D. Program in Chemical Biology,?Vahlteich Medicinal Chemistry Curated by ChEMBL | Assay Description Inhibition of bovine GRK2 S670A mutant after 5 mins in presence of ATP by phosphorimaging assay | J Med Chem 60: 3052-3069 (2017) Article DOI: 10.1021/acs.jmedchem.7b00112 BindingDB Entry DOI: 10.7270/Q2M047XQ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Beta-adrenergic receptor kinase 1 (Homo sapiens (Human)) | BDBM50173319 (CHEMBL3809020 | US10023564, Example 11) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Medicinal Chemistry, College of Pharmacy,?Departments of Pharmacology and Biological Chemistry, Life Sciences Institute,§Ph.D. Program in Chemical Biology,?Vahlteich Medicinal Chemistry Curated by ChEMBL | Assay Description Inhibition of GRK2 (unknown origin) | J Med Chem 60: 3052-3069 (2017) Article DOI: 10.1021/acs.jmedchem.7b00112 BindingDB Entry DOI: 10.7270/Q2M047XQ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Beta-adrenergic receptor kinase 1 (Homo sapiens (Human)) | BDBM50173319 (CHEMBL3809020 | US10023564, Example 11) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB US Patent | n/a | n/a | 130 | n/a | n/a | n/a | n/a | 7.0 | n/a |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent | Assay Description GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e... | US Patent US10023564 (2018) BindingDB Entry DOI: 10.7270/Q2V126V5 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Rho-associated protein kinase 1 (Homo sapiens (Human)) | BDBM50173319 (CHEMBL3809020 | US10023564, Example 11) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent | Assay Description Rho-associated coiled-coil kinase (ROCK) assays were performed with the ADP-Glo system using 0.1 μg ROCK1 and 1 μg S6K substrate, and 100 &... | US Patent US10023564 (2018) BindingDB Entry DOI: 10.7270/Q2V126V5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G protein-coupled receptor kinase 5 (Bos taurus) | BDBM50173319 (CHEMBL3809020 | US10023564, Example 11) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Medicinal Chemistry, College of Pharmacy,?Departments of Pharmacology and Biological Chemistry, Life Sciences Institute,§Ph.D. Program in Chemical Biology,?Vahlteich Medicinal Chemistry Curated by ChEMBL | Assay Description Binding affinity of compound towards dopamine transporter determined using [3H]WIN-35 428 as radioligand | J Med Chem 60: 3052-3069 (2017) Article DOI: 10.1021/acs.jmedchem.7b00112 BindingDB Entry DOI: 10.7270/Q2M047XQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rhodopsin kinase GRK1 (Bos taurus) | BDBM50173319 (CHEMBL3809020 | US10023564, Example 11) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Medicinal Chemistry, College of Pharmacy,?Departments of Pharmacology and Biological Chemistry, Life Sciences Institute,§Ph.D. Program in Chemical Biology,?Vahlteich Medicinal Chemistry Curated by ChEMBL | Assay Description Inhibitory concentration against alpha-galactosidase of coffee bean | J Med Chem 60: 3052-3069 (2017) Article DOI: 10.1021/acs.jmedchem.7b00112 BindingDB Entry DOI: 10.7270/Q2M047XQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rhodopsin kinase GRK1 (Homo sapiens (Human)) | BDBM50173319 (CHEMBL3809020 | US10023564, Example 11) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 7.0 | n/a |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent | Assay Description GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e... | US Patent US10023564 (2018) BindingDB Entry DOI: 10.7270/Q2V126V5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rhodopsin kinase GRK1 (Homo sapiens (Human)) | BDBM50173319 (CHEMBL3809020 | US10023564, Example 11) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Temple University Curated by ChEMBL | Assay Description Inhibition of GRK1 (unknown origin) using tubulin as substrate by SDS-PAGE method | J Med Chem 59: 3793-807 (2016) Article DOI: 10.1021/acs.jmedchem.5b02000 BindingDB Entry DOI: 10.7270/Q2JQ12X4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G protein-coupled receptor kinase 5 (Homo sapiens (Human)) | BDBM50173319 (CHEMBL3809020 | US10023564, Example 11) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Temple University Curated by ChEMBL | Assay Description Inhibition of GRK5 (unknown origin) using tubulin as substrate by SDS-PAGE method | J Med Chem 59: 3793-807 (2016) Article DOI: 10.1021/acs.jmedchem.5b02000 BindingDB Entry DOI: 10.7270/Q2JQ12X4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G protein-coupled receptor kinase 5 (Homo sapiens (Human)) | BDBM50173319 (CHEMBL3809020 | US10023564, Example 11) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 7.0 | n/a |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent | Assay Description GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e... | US Patent US10023564 (2018) BindingDB Entry DOI: 10.7270/Q2V126V5 | |||||||||||
More data for this Ligand-Target Pair |