BindingDB PrimarySearch

Found 7 hits of ic50 for monomerid = 50173328
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Beta-adrenergic receptor kinase 1 (Homo sapiens (Human))	BDBM50173328 (CHEMBL3808918 \| US10023564, Example 14) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	230	n/a	n/a	n/a	n/a	7.0	n/a
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent					Assay Description GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...				US Patent US10023564 (2018) BindingDB Entry DOI: 10.7270/Q2V126V5
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM50173328 (CHEMBL3808918 \| US10023564, Example 14) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
Temple University Curated by ChEMBL					Assay Description Inhibition of ROCK1 (unknown origin) by ADP-Glo kinase assay				J Med Chem 59: 3793-807 (2016) Article DOI: 10.1021/acs.jmedchem.5b02000 BindingDB Entry DOI: 10.7270/Q2JQ12X4
Temple University Curated by ChEMBL					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM50173328 (CHEMBL3808918 \| US10023564, Example 14) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	US Patent	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent					Assay Description Rho-associated coiled-coil kinase (ROCK) assays were performed with the ADP-Glo system using 0.1 μg ROCK1 and 1 μg S6K substrate, and 100 &...				US Patent US10023564 (2018) BindingDB Entry DOI: 10.7270/Q2V126V5
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent					More data for this Ligand-Target Pair
G protein-coupled receptor kinase 5 (Homo sapiens (Human))	BDBM50173328 (CHEMBL3808918 \| US10023564, Example 14) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	US Patent	n/a	n/a	5.80E+4	n/a	n/a	n/a	n/a	7.0	n/a
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent					Assay Description GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...				US Patent US10023564 (2018) BindingDB Entry DOI: 10.7270/Q2V126V5
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent					More data for this Ligand-Target Pair
G protein-coupled receptor kinase 5 (Homo sapiens (Human))	BDBM50173328 (CHEMBL3808918 \| US10023564, Example 14) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	5.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Temple University Curated by ChEMBL					Assay Description Inhibition of GRK5 (unknown origin) using tubulin as substrate by SDS-PAGE method				J Med Chem 59: 3793-807 (2016) Article DOI: 10.1021/acs.jmedchem.5b02000 BindingDB Entry DOI: 10.7270/Q2JQ12X4
Temple University Curated by ChEMBL					More data for this Ligand-Target Pair
Rhodopsin kinase GRK1 (Homo sapiens (Human))	BDBM50173328 (CHEMBL3808918 \| US10023564, Example 14) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Temple University Curated by ChEMBL					Assay Description Inhibition of GRK1 (unknown origin) using tubulin as substrate by SDS-PAGE method				J Med Chem 59: 3793-807 (2016) Article DOI: 10.1021/acs.jmedchem.5b02000 BindingDB Entry DOI: 10.7270/Q2JQ12X4
Temple University Curated by ChEMBL					More data for this Ligand-Target Pair
Rhodopsin kinase GRK1 (Homo sapiens (Human))	BDBM50173328 (CHEMBL3808918 \| US10023564, Example 14) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	7.0	n/a
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent					Assay Description GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...				US Patent US10023564 (2018) BindingDB Entry DOI: 10.7270/Q2V126V5
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent					More data for this Ligand-Target Pair