Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dipeptidyl peptidase 1 (Homo sapiens (Human)) | BDBM50195240 (CHEMBL3960432 | US10287258, Example 3 | US10669245...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED Curated by ChEMBL | Assay Description Inhibition of DPP1 in human U937 cells using Gly-Phe-AFC as substrate preincubated for 60 mins followed by substrate addition by fluorescence assay | J Med Chem 59: 9457-9472 (2016) Article DOI: 10.1021/acs.jmedchem.6b01127 BindingDB Entry DOI: 10.7270/Q2Z321K4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase 1 (Homo sapiens (Human)) | BDBM50195240 (CHEMBL3960432 | US10287258, Example 3 | US10669245...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED Curated by ChEMBL | Assay Description Inhibition of human recombinant DPP1 using Gly-Arg-AMC as substrate preincubated for 30 mins followed by substrate addition by fluorometric assay | J Med Chem 59: 9457-9472 (2016) Article DOI: 10.1021/acs.jmedchem.6b01127 BindingDB Entry DOI: 10.7270/Q2Z321K4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase 1 (Homo sapiens (Human)) | BDBM50195240 (CHEMBL3960432 | US10287258, Example 3 | US10669245...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 10.2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis | Assay Description The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic... | J Med Chem 51: 7049-52 (2008) BindingDB Entry DOI: 10.7270/Q2RJ4MTP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase 1 (Homo sapiens (Human)) | BDBM50195240 (CHEMBL3960432 | US10287258, Example 3 | US10669245...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | n/a | n/a | 10.2 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2F76HN2 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase 1 (Homo sapiens (Human)) | BDBM50195240 (CHEMBL3960432 | US10287258, Example 3 | US10669245...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | n/a | n/a | 10.2 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2FB56W4 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase 1 (Homo sapiens (Human)) | BDBM50195240 (CHEMBL3960432 | US10287258, Example 3 | US10669245...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | n/a | n/a | 10.2 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2ZG6X5T | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase 1 (Homo sapiens (Human)) | BDBM50195240 (CHEMBL3960432 | US10287258, Example 3 | US10669245...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 10.2 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB US Patent | Assay Description The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic... | US Patent US10669245 (2020) BindingDB Entry DOI: 10.7270/Q2862KG7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase 1 (Homo sapiens (Human)) | BDBM50195240 (CHEMBL3960432 | US10287258, Example 3 | US10669245...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 10.2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Examples 1-35: The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly... | Citation and Details BindingDB Entry DOI: 10.7270/Q2Q243DZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase 1 (Homo sapiens (Human)) | BDBM50195240 (CHEMBL3960432 | US10287258, Example 3 | US10669245...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | n/a | n/a | 10.2 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q24X5CXQ | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase 1 (Homo sapiens (Human)) | BDBM50195240 (CHEMBL3960432 | US10287258, Example 3 | US10669245...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | n/a | n/a | 10.2 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2H99949 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM50195240 (CHEMBL3960432 | US10287258, Example 3 | US10669245...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >3.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED Curated by ChEMBL | Assay Description Inhibition of human ERG | J Med Chem 59: 9457-9472 (2016) Article DOI: 10.1021/acs.jmedchem.6b01127 BindingDB Entry DOI: 10.7270/Q2Z321K4 | |||||||||||
More data for this Ligand-Target Pair |