Found 3 hits of ic50 for monomerid = 50197658 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Platelet-activating factor acetylhydrolase
(Homo sapiens (Human)) | BDBM50197658
(CHEMBL3897162)Show SMILES CN1CCC(C)(CC1)C1CN(CCOc2ccc(F)c(c2)C#N)C(=O)C1 Show InChI InChI=1S/C20H26FN3O2/c1-20(5-7-23(2)8-6-20)16-12-19(25)24(14-16)9-10-26-17-3-4-18(21)15(11-17)13-22/h3-4,11,16H,5-10,12,14H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 75 | n/a | n/a | n/a | n/a | n/a | n/a |
Astex Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of recombinant human Lp-PLA2 pre-incubated for 30 mins before PED6 fluorogenic substrate |
J Med Chem 59: 10738-10749 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01427 BindingDB Entry DOI: 10.7270/Q27946ND |
More data for this Ligand-Target Pair | |
Platelet-activating factor acetylhydrolase
(Homo sapiens (Human)) | BDBM50197658
(CHEMBL3897162)Show SMILES CN1CCC(C)(CC1)C1CN(CCOc2ccc(F)c(c2)C#N)C(=O)C1 Show InChI InChI=1S/C20H26FN3O2/c1-20(5-7-23(2)8-6-20)16-12-19(25)24(14-16)9-10-26-17-3-4-18(21)15(11-17)13-22/h3-4,11,16H,5-10,12,14H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
Astex Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of Lp-PLA2 in whole human plasma pre-incubated for 15 mins before 2-thio-PAF substrate addition |
J Med Chem 59: 10738-10749 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01427 BindingDB Entry DOI: 10.7270/Q27946ND |
More data for this Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50197658
(CHEMBL3897162)Show SMILES CN1CCC(C)(CC1)C1CN(CCOc2ccc(F)c(c2)C#N)C(=O)C1 Show InChI InChI=1S/C20H26FN3O2/c1-20(5-7-23(2)8-6-20)16-12-19(25)24(14-16)9-10-26-17-3-4-18(21)15(11-17)13-22/h3-4,11,16H,5-10,12,14H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Astex Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of CYP3A4 (unknown origin) expressed in Escherichia coli co-expressing human NADPH reductase using both 7-benzyloxyquinolone and diethoxyf... |
J Med Chem 59: 10738-10749 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01427 BindingDB Entry DOI: 10.7270/Q27946ND |
More data for this Ligand-Target Pair | |