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Compile Data Set for Download or QSAR

Found 1 hit of ic50 for monomerid = 50205630   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))		BDBM50205630
PNG
(CHEMBL3915266)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3N(CCc23)C2CCOCC2)-c2ccc(CN3CCOCC3)cc2)c(=O)[nH]1
Show InChI InChI=1S/C33H40N4O4/c1-22-17-23(2)35-33(39)30(22)20-34-32(38)29-18-26(19-31-28(29)7-10-37(31)27-8-13-40-14-9-27)25-5-3-24(4-6-25)21-36-11-15-41-16-12-36/h3-6,17-19,27H,7-16,20-21H2,1-2H3,(H,34,38)(H,35,39)
PDB

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UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 237n/an/an/an/an/an/a



Integral BioSciences Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human wild type EZH2 using histone H3 as substrate after 1 hr in presence of 3H-SAM by filter paper detection analysis

Bioorg Med Chem Lett 27: 217-222 (2017)


Article DOI: 10.1016/j.bmcl.2016.11.080
BindingDB Entry DOI: 10.7270/Q2S46TZW
More data for this
Ligand-Target Pair