Found 5 hits of ic50 for monomerid = 50233393 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Tyrosine-protein kinase BTK
(Homo sapiens (Human)) | BDBM50233393
(CHEMBL4096195)Show SMILES CC(C)[C@]1(CC[C@](C)(C1)c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12)C(O)=O |r| Show InChI InChI=1S/C29H29F3N6O3/c1-16(2)28(26(40)41)10-9-27(3,15-28)25-37-21(22-23(33)35-12-13-38(22)25)17-4-6-18(7-5-17)24(39)36-20-14-19(8-11-34-20)29(30,31)32/h4-8,11-14,16H,9-10,15H2,1-3H3,(H2,33,35)(H,40,41)(H,34,36,39)/t27-,28-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co Inc
Curated by ChEMBL
| Assay Description
Inhibition of 6-His-tagged recombinant full length BTK (unknown origin) expressed in baculovirus-transfected Sf9 cells using Biotin-EQEDEPEGDYFEWLE-N... |
Bioorg Med Chem Lett 27: 1471-1477 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.079
BindingDB Entry DOI: 10.7270/Q20867K5 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase BTK
(Homo sapiens (Human)) | BDBM50233393
(CHEMBL4096195)Show SMILES CC(C)[C@]1(CC[C@](C)(C1)c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12)C(O)=O |r| Show InChI InChI=1S/C29H29F3N6O3/c1-16(2)28(26(40)41)10-9-27(3,15-28)25-37-21(22-23(33)35-12-13-38(22)25)17-4-6-18(7-5-17)24(39)36-20-14-19(8-11-34-20)29(30,31)32/h4-8,11-14,16H,9-10,15H2,1-3H3,(H2,33,35)(H,40,41)(H,34,36,39)/t27-,28-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co Inc
Curated by ChEMBL
| Assay Description
Inhibition of BTK in human PBMC |
Bioorg Med Chem Lett 27: 1471-1477 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.079
BindingDB Entry DOI: 10.7270/Q20867K5 |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1C
(Homo sapiens (Human)) | BDBM50233393
(CHEMBL4096195)Show SMILES CC(C)[C@]1(CC[C@](C)(C1)c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12)C(O)=O |r| Show InChI InChI=1S/C29H29F3N6O3/c1-16(2)28(26(40)41)10-9-27(3,15-28)25-37-21(22-23(33)35-12-13-38(22)25)17-4-6-18(7-5-17)24(39)36-20-14-19(8-11-34-20)29(30,31)32/h4-8,11-14,16H,9-10,15H2,1-3H3,(H2,33,35)(H,40,41)(H,34,36,39)/t27-,28-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co Inc
Curated by ChEMBL
| Assay Description
Inhibition of Cav1.2 (unknown origin) |
Bioorg Med Chem Lett 27: 1471-1477 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.079
BindingDB Entry DOI: 10.7270/Q20867K5 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human)) | BDBM50233393
(CHEMBL4096195)Show SMILES CC(C)[C@]1(CC[C@](C)(C1)c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12)C(O)=O |r| Show InChI InChI=1S/C29H29F3N6O3/c1-16(2)28(26(40)41)10-9-27(3,15-28)25-37-21(22-23(33)35-12-13-38(22)25)17-4-6-18(7-5-17)24(39)36-20-14-19(8-11-34-20)29(30,31)32/h4-8,11-14,16H,9-10,15H2,1-3H3,(H2,33,35)(H,40,41)(H,34,36,39)/t27-,28-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co Inc
Curated by ChEMBL
| Assay Description
Inhibition of Nav1.5 (unknown origin) |
Bioorg Med Chem Lett 27: 1471-1477 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.079
BindingDB Entry DOI: 10.7270/Q20867K5 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50233393
(CHEMBL4096195)Show SMILES CC(C)[C@]1(CC[C@](C)(C1)c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12)C(O)=O |r| Show InChI InChI=1S/C29H29F3N6O3/c1-16(2)28(26(40)41)10-9-27(3,15-28)25-37-21(22-23(33)35-12-13-38(22)25)17-4-6-18(7-5-17)24(39)36-20-14-19(8-11-34-20)29(30,31)32/h4-8,11-14,16H,9-10,15H2,1-3H3,(H2,33,35)(H,40,41)(H,34,36,39)/t27-,28-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >6.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co Inc
Curated by ChEMBL
| Assay Description
Inhibition of human ERG |
Bioorg Med Chem Lett 27: 1471-1477 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.079
BindingDB Entry DOI: 10.7270/Q20867K5 |
More data for this
Ligand-Target Pair | |
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