Found 5 hits of ic50 for monomerid = 50243904 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Tyrosine-protein kinase JAK1
(Homo sapiens (Human)) | BDBM50243904
(CHEMBL4103435)Show SMILES CN([C@@H]1C[C@@H](C1)NS(=O)(=O)CCC(F)(F)F)c1ncnc2[nH]ccc12 |r,wD:2.1,4.6,(7.09,-13.36,;8.42,-14.12,;9.75,-13.35,;10.15,-11.85,;11.64,-12.25,;11.24,-13.74,;12.97,-11.47,;14.3,-12.23,;15.06,-13.56,;13.52,-13.56,;15.63,-11.46,;16.97,-12.24,;18.3,-11.47,;19.63,-12.24,;18.3,-9.93,;19.63,-10.69,;8.43,-15.66,;7.1,-16.43,;7.1,-17.98,;8.43,-18.75,;9.77,-17.97,;11.24,-18.44,;12.14,-17.18,;11.23,-15.94,;9.76,-16.43,)| Show InChI InChI=1S/C14H18F3N5O2S/c1-22(13-11-2-4-18-12(11)19-8-20-13)10-6-9(7-10)21-25(23,24)5-3-14(15,16)17/h2,4,8-10,21H,3,5-7H2,1H3,(H,18,19,20)/t9-,10+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human JAK1 using 5'FAM-KKSRGDYMTMQID as substrate in presence of 1 mM ATP by mobility shift assay |
J Med Chem 61: 1130-1152 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01598
BindingDB Entry DOI: 10.7270/Q2D79DTW |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50243904
(CHEMBL4103435)Show SMILES CN([C@@H]1C[C@@H](C1)NS(=O)(=O)CCC(F)(F)F)c1ncnc2[nH]ccc12 |r,wD:2.1,4.6,(7.09,-13.36,;8.42,-14.12,;9.75,-13.35,;10.15,-11.85,;11.64,-12.25,;11.24,-13.74,;12.97,-11.47,;14.3,-12.23,;15.06,-13.56,;13.52,-13.56,;15.63,-11.46,;16.97,-12.24,;18.3,-11.47,;19.63,-12.24,;18.3,-9.93,;19.63,-10.69,;8.43,-15.66,;7.1,-16.43,;7.1,-17.98,;8.43,-18.75,;9.77,-17.97,;11.24,-18.44,;12.14,-17.18,;11.23,-15.94,;9.76,-16.43,)| Show InChI InChI=1S/C14H18F3N5O2S/c1-22(13-11-2-4-18-12(11)19-8-20-13)10-6-9(7-10)21-25(23,24)5-3-14(15,16)17/h2,4,8-10,21H,3,5-7H2,1H3,(H,18,19,20)/t9-,10+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 592 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human JAK2 using FITC-KGGEEEEYFELVKK as substrate in presence of 1 mM ATP by mobility shift assay |
J Med Chem 61: 1130-1152 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01598
BindingDB Entry DOI: 10.7270/Q2D79DTW |
More data for this
Ligand-Target Pair | |
Non-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1
(Homo sapiens (Human)) | BDBM50243904
(CHEMBL4103435)Show SMILES CN([C@@H]1C[C@@H](C1)NS(=O)(=O)CCC(F)(F)F)c1ncnc2[nH]ccc12 |r,wD:2.1,4.6,(7.09,-13.36,;8.42,-14.12,;9.75,-13.35,;10.15,-11.85,;11.64,-12.25,;11.24,-13.74,;12.97,-11.47,;14.3,-12.23,;15.06,-13.56,;13.52,-13.56,;15.63,-11.46,;16.97,-12.24,;18.3,-11.47,;19.63,-12.24,;18.3,-9.93,;19.63,-10.69,;8.43,-15.66,;7.1,-16.43,;7.1,-17.98,;8.43,-18.75,;9.77,-17.97,;11.24,-18.44,;12.14,-17.18,;11.23,-15.94,;9.76,-16.43,)| Show InChI InChI=1S/C14H18F3N5O2S/c1-22(13-11-2-4-18-12(11)19-8-20-13)10-6-9(7-10)21-25(23,24)5-3-14(15,16)17/h2,4,8-10,21H,3,5-7H2,1H3,(H,18,19,20)/t9-,10+ | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 692 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of JAK1/TYK2 in human whole blood assessed as reduction in IFNalpha induced STAT3 phosphorylation preincubated for 45 mins followed by IFN... |
J Med Chem 61: 1130-1152 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01598
BindingDB Entry DOI: 10.7270/Q2D79DTW |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50243904
(CHEMBL4103435)Show SMILES CN([C@@H]1C[C@@H](C1)NS(=O)(=O)CCC(F)(F)F)c1ncnc2[nH]ccc12 |r,wD:2.1,4.6,(7.09,-13.36,;8.42,-14.12,;9.75,-13.35,;10.15,-11.85,;11.64,-12.25,;11.24,-13.74,;12.97,-11.47,;14.3,-12.23,;15.06,-13.56,;13.52,-13.56,;15.63,-11.46,;16.97,-12.24,;18.3,-11.47,;19.63,-12.24,;18.3,-9.93,;19.63,-10.69,;8.43,-15.66,;7.1,-16.43,;7.1,-17.98,;8.43,-18.75,;9.77,-17.97,;11.24,-18.44,;12.14,-17.18,;11.23,-15.94,;9.76,-16.43,)| Show InChI InChI=1S/C14H18F3N5O2S/c1-22(13-11-2-4-18-12(11)19-8-20-13)10-6-9(7-10)21-25(23,24)5-3-14(15,16)17/h2,4,8-10,21H,3,5-7H2,1H3,(H,18,19,20)/t9-,10+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.11E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor |
J Med Chem 61: 1130-1152 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01598
BindingDB Entry DOI: 10.7270/Q2D79DTW |
More data for this
Ligand-Target Pair | |
Non-receptor tyrosine-protein kinase TYK2
(Homo sapiens (Human)) | BDBM50243904
(CHEMBL4103435)Show SMILES CN([C@@H]1C[C@@H](C1)NS(=O)(=O)CCC(F)(F)F)c1ncnc2[nH]ccc12 |r,wD:2.1,4.6,(7.09,-13.36,;8.42,-14.12,;9.75,-13.35,;10.15,-11.85,;11.64,-12.25,;11.24,-13.74,;12.97,-11.47,;14.3,-12.23,;15.06,-13.56,;13.52,-13.56,;15.63,-11.46,;16.97,-12.24,;18.3,-11.47,;19.63,-12.24,;18.3,-9.93,;19.63,-10.69,;8.43,-15.66,;7.1,-16.43,;7.1,-17.98,;8.43,-18.75,;9.77,-17.97,;11.24,-18.44,;12.14,-17.18,;11.23,-15.94,;9.76,-16.43,)| Show InChI InChI=1S/C14H18F3N5O2S/c1-22(13-11-2-4-18-12(11)19-8-20-13)10-6-9(7-10)21-25(23,24)5-3-14(15,16)17/h2,4,8-10,21H,3,5-7H2,1H3,(H,18,19,20)/t9-,10+ | PDB
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TYK2 using 5'FAM-KKSRGDYMTMQID as substrate in presence of 1 mM ATP by mobility shift assay |
J Med Chem 61: 1130-1152 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01598
BindingDB Entry DOI: 10.7270/Q2D79DTW |
More data for this
Ligand-Target Pair | |
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