Found 2 hits of ic50 for monomerid = 50265887 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50265887
(4-(2-(1-(2-(dimethylamino)acetyl)-5-methoxyindolin...)Show SMILES CNC(=O)c1cscc1Nc1nc(Nc2cc3N(CCc3cc2OC)C(=O)CN(C)C)nc2[nH]ccc12 Show InChI InChI=1S/C25H28N8O3S/c1-26-24(35)16-12-37-13-18(16)28-23-15-5-7-27-22(15)30-25(31-23)29-17-10-19-14(9-20(17)36-4)6-8-33(19)21(34)11-32(2)3/h5,7,9-10,12-13H,6,8,11H2,1-4H3,(H,26,35)(H3,27,28,29,30,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of IGF1R |
Bioorg Med Chem Lett 19: 373-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.065 BindingDB Entry DOI: 10.7270/Q2F190PC |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50265887
(4-(2-(1-(2-(dimethylamino)acetyl)-5-methoxyindolin...)Show SMILES CNC(=O)c1cscc1Nc1nc(Nc2cc3N(CCc3cc2OC)C(=O)CN(C)C)nc2[nH]ccc12 Show InChI InChI=1S/C25H28N8O3S/c1-26-24(35)16-12-37-13-18(16)28-23-15-5-7-27-22(15)30-25(31-23)29-17-10-19-14(9-20(17)36-4)6-8-33(19)21(34)11-32(2)3/h5,7,9-10,12-13H,6,8,11H2,1-4H3,(H,26,35)(H3,27,28,29,30,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of IGF1R phosphorylation by cellular assay |
Bioorg Med Chem Lett 19: 373-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.065 BindingDB Entry DOI: 10.7270/Q2F190PC |
More data for this Ligand-Target Pair | |