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Compile Data Set for Download or QSAR

Found 1 hit of ic50 for monomerid = 50308554   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50308554
PNG
(3-(4-(3-hydroxypropyl)-1,4-diazepan-1-yl)-1-(2-pro...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N2CCCN(CCCO)CC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C26H36N6O4/c1-3-15-36-16-13-32-23-17-21(20-6-7-24(35-2)28-18-20)27-19-22(23)29-25(26(32)34)31-10-4-8-30(11-12-31)9-5-14-33/h6-7,17-19,33H,3-5,8-16H2,1-2H3
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Article
PubMed
n/an/a 1.10n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assay

J Med Chem 53: 2656-60 (2010)


Article DOI: 10.1021/jm901781q
BindingDB Entry DOI: 10.7270/Q2VM4CCK
More data for this
Ligand-Target Pair