Found 8 hits of ic50 for monomerid = 50311917 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50311917
(CHEMBL1079945 | N-(3-(1-(6-aminopyrimidin-4-yl)-1H...)Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1Nc1nc2ccccc2n1-c1cc(N)ncn1 Show InChI InChI=1S/C26H20F3N7O/c1-15-9-10-18(33-24(37)16-5-4-6-17(11-16)26(27,28)29)12-20(15)35-25-34-19-7-2-3-8-21(19)36(25)23-13-22(30)31-14-32-23/h2-14H,1H3,(H,33,37)(H,34,35)(H2,30,31,32) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
| Assay Description
Inhibition of Tel-fused LCK expressed in mouse BAF3 cells |
Bioorg Med Chem Lett 19: 6691-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.123
BindingDB Entry DOI: 10.7270/Q2Q52PRR |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50311917
(CHEMBL1079945 | N-(3-(1-(6-aminopyrimidin-4-yl)-1H...)Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1Nc1nc2ccccc2n1-c1cc(N)ncn1 Show InChI InChI=1S/C26H20F3N7O/c1-15-9-10-18(33-24(37)16-5-4-6-17(11-16)26(27,28)29)12-20(15)35-25-34-19-7-2-3-8-21(19)36(25)23-13-22(30)31-14-32-23/h2-14H,1H3,(H,33,37)(H,34,35)(H2,30,31,32) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
| Assay Description
Inhibition of LCK |
Bioorg Med Chem Lett 19: 6691-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.123
BindingDB Entry DOI: 10.7270/Q2Q52PRR |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lyn
(Homo sapiens (Human)) | BDBM50311917
(CHEMBL1079945 | N-(3-(1-(6-aminopyrimidin-4-yl)-1H...)Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1Nc1nc2ccccc2n1-c1cc(N)ncn1 Show InChI InChI=1S/C26H20F3N7O/c1-15-9-10-18(33-24(37)16-5-4-6-17(11-16)26(27,28)29)12-20(15)35-25-34-19-7-2-3-8-21(19)36(25)23-13-22(30)31-14-32-23/h2-14H,1H3,(H,33,37)(H,34,35)(H2,30,31,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
| Assay Description
Inhibition of Tel-fused LYN expressed in mouse BAF3 cells |
Bioorg Med Chem Lett 19: 6691-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.123
BindingDB Entry DOI: 10.7270/Q2Q52PRR |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50311917
(CHEMBL1079945 | N-(3-(1-(6-aminopyrimidin-4-yl)-1H...)Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1Nc1nc2ccccc2n1-c1cc(N)ncn1 Show InChI InChI=1S/C26H20F3N7O/c1-15-9-10-18(33-24(37)16-5-4-6-17(11-16)26(27,28)29)12-20(15)35-25-34-19-7-2-3-8-21(19)36(25)23-13-22(30)31-14-32-23/h2-14H,1H3,(H,33,37)(H,34,35)(H2,30,31,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
| Assay Description
Inhibition of Tel-fused KDR expressed in mouse BAF3 cells |
Bioorg Med Chem Lett 19: 6691-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.123
BindingDB Entry DOI: 10.7270/Q2Q52PRR |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM50311917
(CHEMBL1079945 | N-(3-(1-(6-aminopyrimidin-4-yl)-1H...)Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1Nc1nc2ccccc2n1-c1cc(N)ncn1 Show InChI InChI=1S/C26H20F3N7O/c1-15-9-10-18(33-24(37)16-5-4-6-17(11-16)26(27,28)29)12-20(15)35-25-34-19-7-2-3-8-21(19)36(25)23-13-22(30)31-14-32-23/h2-14H,1H3,(H,33,37)(H,34,35)(H2,30,31,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
| Assay Description
Inhibition of HCK |
Bioorg Med Chem Lett 19: 6691-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.123
BindingDB Entry DOI: 10.7270/Q2Q52PRR |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50311917
(CHEMBL1079945 | N-(3-(1-(6-aminopyrimidin-4-yl)-1H...)Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1Nc1nc2ccccc2n1-c1cc(N)ncn1 Show InChI InChI=1S/C26H20F3N7O/c1-15-9-10-18(33-24(37)16-5-4-6-17(11-16)26(27,28)29)12-20(15)35-25-34-19-7-2-3-8-21(19)36(25)23-13-22(30)31-14-32-23/h2-14H,1H3,(H,33,37)(H,34,35)(H2,30,31,32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 78 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
| Assay Description
Inhibition of Tel-fused SRC expressed in mouse BAF3 cells |
Bioorg Med Chem Lett 19: 6691-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.123
BindingDB Entry DOI: 10.7270/Q2Q52PRR |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50311917
(CHEMBL1079945 | N-(3-(1-(6-aminopyrimidin-4-yl)-1H...)Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1Nc1nc2ccccc2n1-c1cc(N)ncn1 Show InChI InChI=1S/C26H20F3N7O/c1-15-9-10-18(33-24(37)16-5-4-6-17(11-16)26(27,28)29)12-20(15)35-25-34-19-7-2-3-8-21(19)36(25)23-13-22(30)31-14-32-23/h2-14H,1H3,(H,33,37)(H,34,35)(H2,30,31,32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
| Assay Description
Inhibition of SRC |
Bioorg Med Chem Lett 19: 6691-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.123
BindingDB Entry DOI: 10.7270/Q2Q52PRR |
More data for this
Ligand-Target Pair | |
Insulin receptor
(Homo sapiens (Human)) | BDBM50311917
(CHEMBL1079945 | N-(3-(1-(6-aminopyrimidin-4-yl)-1H...)Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1Nc1nc2ccccc2n1-c1cc(N)ncn1 Show InChI InChI=1S/C26H20F3N7O/c1-15-9-10-18(33-24(37)16-5-4-6-17(11-16)26(27,28)29)12-20(15)35-25-34-19-7-2-3-8-21(19)36(25)23-13-22(30)31-14-32-23/h2-14H,1H3,(H,33,37)(H,34,35)(H2,30,31,32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 661 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
| Assay Description
Inhibition of Tel-fused InsR expressed in mouse BAF3 cells |
Bioorg Med Chem Lett 19: 6691-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.123
BindingDB Entry DOI: 10.7270/Q2Q52PRR |
More data for this
Ligand-Target Pair | |
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