Found 8 hits of ic50 for monomerid = 50311924 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50311924
(CHEMBL1076433 | N-(3-(1-(6-aminopyrimidin-4-yl)-1H...)Show SMILES CCN1CCN(Cc2ccc(cc2Cl)C(=O)Nc2ccc(C)c(Nc3nc4ccccc4n3-c3cc(N)ncn3)c2)CC1 Show InChI InChI=1S/C32H34ClN9O/c1-3-40-12-14-41(15-13-40)19-23-10-9-22(16-25(23)33)31(43)37-24-11-8-21(2)27(17-24)39-32-38-26-6-4-5-7-28(26)42(32)30-18-29(34)35-20-36-30/h4-11,16-18,20H,3,12-15,19H2,1-2H3,(H,37,43)(H,38,39)(H2,34,35,36) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
| Assay Description
Inhibition of LCK |
Bioorg Med Chem Lett 19: 6691-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.123
BindingDB Entry DOI: 10.7270/Q2Q52PRR |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50311924
(CHEMBL1076433 | N-(3-(1-(6-aminopyrimidin-4-yl)-1H...)Show SMILES CCN1CCN(Cc2ccc(cc2Cl)C(=O)Nc2ccc(C)c(Nc3nc4ccccc4n3-c3cc(N)ncn3)c2)CC1 Show InChI InChI=1S/C32H34ClN9O/c1-3-40-12-14-41(15-13-40)19-23-10-9-22(16-25(23)33)31(43)37-24-11-8-21(2)27(17-24)39-32-38-26-6-4-5-7-28(26)42(32)30-18-29(34)35-20-36-30/h4-11,16-18,20H,3,12-15,19H2,1-2H3,(H,37,43)(H,38,39)(H2,34,35,36) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
| Assay Description
Inhibition of Tel-fused LCK expressed in mouse BAF3 cells |
Bioorg Med Chem Lett 19: 6691-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.123
BindingDB Entry DOI: 10.7270/Q2Q52PRR |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase HCK
(Homo sapiens (Human)) | BDBM50311924
(CHEMBL1076433 | N-(3-(1-(6-aminopyrimidin-4-yl)-1H...)Show SMILES CCN1CCN(Cc2ccc(cc2Cl)C(=O)Nc2ccc(C)c(Nc3nc4ccccc4n3-c3cc(N)ncn3)c2)CC1 Show InChI InChI=1S/C32H34ClN9O/c1-3-40-12-14-41(15-13-40)19-23-10-9-22(16-25(23)33)31(43)37-24-11-8-21(2)27(17-24)39-32-38-26-6-4-5-7-28(26)42(32)30-18-29(34)35-20-36-30/h4-11,16-18,20H,3,12-15,19H2,1-2H3,(H,37,43)(H,38,39)(H2,34,35,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
| Assay Description
Inhibition of HCK |
Bioorg Med Chem Lett 19: 6691-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.123
BindingDB Entry DOI: 10.7270/Q2Q52PRR |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lyn
(Homo sapiens (Human)) | BDBM50311924
(CHEMBL1076433 | N-(3-(1-(6-aminopyrimidin-4-yl)-1H...)Show SMILES CCN1CCN(Cc2ccc(cc2Cl)C(=O)Nc2ccc(C)c(Nc3nc4ccccc4n3-c3cc(N)ncn3)c2)CC1 Show InChI InChI=1S/C32H34ClN9O/c1-3-40-12-14-41(15-13-40)19-23-10-9-22(16-25(23)33)31(43)37-24-11-8-21(2)27(17-24)39-32-38-26-6-4-5-7-28(26)42(32)30-18-29(34)35-20-36-30/h4-11,16-18,20H,3,12-15,19H2,1-2H3,(H,37,43)(H,38,39)(H2,34,35,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
| Assay Description
Inhibition of Tel-fused LYN expressed in mouse BAF3 cells |
Bioorg Med Chem Lett 19: 6691-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.123
BindingDB Entry DOI: 10.7270/Q2Q52PRR |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50311924
(CHEMBL1076433 | N-(3-(1-(6-aminopyrimidin-4-yl)-1H...)Show SMILES CCN1CCN(Cc2ccc(cc2Cl)C(=O)Nc2ccc(C)c(Nc3nc4ccccc4n3-c3cc(N)ncn3)c2)CC1 Show InChI InChI=1S/C32H34ClN9O/c1-3-40-12-14-41(15-13-40)19-23-10-9-22(16-25(23)33)31(43)37-24-11-8-21(2)27(17-24)39-32-38-26-6-4-5-7-28(26)42(32)30-18-29(34)35-20-36-30/h4-11,16-18,20H,3,12-15,19H2,1-2H3,(H,37,43)(H,38,39)(H2,34,35,36) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
| Assay Description
Inhibition of Tel-fused KDR expressed in mouse BAF3 cells |
Bioorg Med Chem Lett 19: 6691-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.123
BindingDB Entry DOI: 10.7270/Q2Q52PRR |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50311924
(CHEMBL1076433 | N-(3-(1-(6-aminopyrimidin-4-yl)-1H...)Show SMILES CCN1CCN(Cc2ccc(cc2Cl)C(=O)Nc2ccc(C)c(Nc3nc4ccccc4n3-c3cc(N)ncn3)c2)CC1 Show InChI InChI=1S/C32H34ClN9O/c1-3-40-12-14-41(15-13-40)19-23-10-9-22(16-25(23)33)31(43)37-24-11-8-21(2)27(17-24)39-32-38-26-6-4-5-7-28(26)42(32)30-18-29(34)35-20-36-30/h4-11,16-18,20H,3,12-15,19H2,1-2H3,(H,37,43)(H,38,39)(H2,34,35,36) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
| Assay Description
Inhibition of SRC |
Bioorg Med Chem Lett 19: 6691-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.123
BindingDB Entry DOI: 10.7270/Q2Q52PRR |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50311924
(CHEMBL1076433 | N-(3-(1-(6-aminopyrimidin-4-yl)-1H...)Show SMILES CCN1CCN(Cc2ccc(cc2Cl)C(=O)Nc2ccc(C)c(Nc3nc4ccccc4n3-c3cc(N)ncn3)c2)CC1 Show InChI InChI=1S/C32H34ClN9O/c1-3-40-12-14-41(15-13-40)19-23-10-9-22(16-25(23)33)31(43)37-24-11-8-21(2)27(17-24)39-32-38-26-6-4-5-7-28(26)42(32)30-18-29(34)35-20-36-30/h4-11,16-18,20H,3,12-15,19H2,1-2H3,(H,37,43)(H,38,39)(H2,34,35,36) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
| Assay Description
Inhibition of Tel-fused SRC expressed in mouse BAF3 cells |
Bioorg Med Chem Lett 19: 6691-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.123
BindingDB Entry DOI: 10.7270/Q2Q52PRR |
More data for this
Ligand-Target Pair | |
Insulin receptor
(Homo sapiens (Human)) | BDBM50311924
(CHEMBL1076433 | N-(3-(1-(6-aminopyrimidin-4-yl)-1H...)Show SMILES CCN1CCN(Cc2ccc(cc2Cl)C(=O)Nc2ccc(C)c(Nc3nc4ccccc4n3-c3cc(N)ncn3)c2)CC1 Show InChI InChI=1S/C32H34ClN9O/c1-3-40-12-14-41(15-13-40)19-23-10-9-22(16-25(23)33)31(43)37-24-11-8-21(2)27(17-24)39-32-38-26-6-4-5-7-28(26)42(32)30-18-29(34)35-20-36-30/h4-11,16-18,20H,3,12-15,19H2,1-2H3,(H,37,43)(H,38,39)(H2,34,35,36) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation (GNF)
Curated by ChEMBL
| Assay Description
Inhibition of Tel-fused InsR expressed in mouse BAF3 cells |
Bioorg Med Chem Lett 19: 6691-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.123
BindingDB Entry DOI: 10.7270/Q2Q52PRR |
More data for this
Ligand-Target Pair | |
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