Found 2 hits of ic50 for monomerid = 50320096 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50320096
(1-(2-((7-fluoro-5-methoxy-2-(1,3,5-trimethyl-1H-py...)Show SMILES COc1cc(F)c2[nH]c(c(\C=C3\Oc4ccc(NC(=O)Nc5cccnc5)cc4C3=O)c2c1)-c1c(C)nn(C)c1C |(-3.89,-40.1,;-3.89,-41.64,;-2.56,-42.41,;-2.56,-43.96,;-1.22,-44.72,;-1.22,-46.26,;.11,-43.95,;1.58,-44.42,;2.48,-43.17,;1.58,-41.92,;2.17,-40.5,;1.41,-39.17,;2.03,-37.76,;.88,-36.74,;.88,-35.21,;-.44,-34.43,;-1.78,-35.21,;-3.11,-34.45,;-3.12,-32.9,;-1.79,-32.13,;-4.46,-32.14,;-4.47,-30.61,;-5.8,-29.86,;-5.81,-28.33,;-4.49,-27.55,;-3.15,-28.31,;-3.14,-29.84,;-1.77,-36.75,;-.44,-37.5,;-.12,-39.01,;-1.16,-40.16,;.11,-42.4,;-1.23,-41.64,;4.02,-43.17,;4.92,-44.42,;4.45,-45.88,;6.39,-43.95,;6.39,-42.4,;7.64,-41.5,;4.92,-41.92,;4.45,-40.46,)| Show InChI InChI=1S/C30H25FN6O4/c1-15-26(16(2)37(3)36-15)28-21(20-11-19(40-4)12-23(31)27(20)35-28)13-25-29(38)22-10-17(7-8-24(22)41-25)33-30(39)34-18-6-5-9-32-14-18/h5-14,35H,1-4H3,(H2,33,34,39)/b25-13+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha |
Bioorg Med Chem Lett 20: 3526-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.04.139 BindingDB Entry DOI: 10.7270/Q2FQ9WSC |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM50320096
(1-(2-((7-fluoro-5-methoxy-2-(1,3,5-trimethyl-1H-py...)Show SMILES COc1cc(F)c2[nH]c(c(\C=C3\Oc4ccc(NC(=O)Nc5cccnc5)cc4C3=O)c2c1)-c1c(C)nn(C)c1C |(-3.89,-40.1,;-3.89,-41.64,;-2.56,-42.41,;-2.56,-43.96,;-1.22,-44.72,;-1.22,-46.26,;.11,-43.95,;1.58,-44.42,;2.48,-43.17,;1.58,-41.92,;2.17,-40.5,;1.41,-39.17,;2.03,-37.76,;.88,-36.74,;.88,-35.21,;-.44,-34.43,;-1.78,-35.21,;-3.11,-34.45,;-3.12,-32.9,;-1.79,-32.13,;-4.46,-32.14,;-4.47,-30.61,;-5.8,-29.86,;-5.81,-28.33,;-4.49,-27.55,;-3.15,-28.31,;-3.14,-29.84,;-1.77,-36.75,;-.44,-37.5,;-.12,-39.01,;-1.16,-40.16,;.11,-42.4,;-1.23,-41.64,;4.02,-43.17,;4.92,-44.42,;4.45,-45.88,;6.39,-43.95,;6.39,-42.4,;7.64,-41.5,;4.92,-41.92,;4.45,-40.46,)| Show InChI InChI=1S/C30H25FN6O4/c1-15-26(16(2)37(3)36-15)28-21(20-11-19(40-4)12-23(31)27(20)35-28)13-25-29(38)22-10-17(7-8-24(22)41-25)33-30(39)34-18-6-5-9-32-14-18/h5-14,35H,1-4H3,(H2,33,34,39)/b25-13+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of mTOR |
Bioorg Med Chem Lett 20: 3526-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.04.139 BindingDB Entry DOI: 10.7270/Q2FQ9WSC |
More data for this Ligand-Target Pair | |