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Compile Data Set for Download or QSAR

Found 2 hits of ic50 for monomerid = 50343198   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50343198
PNG
(CHEMBL1773600 | N-(6-(6-(4-Methoxyphenylsulfonamid...)
Show SMILES COc1ccc(cc1)S(=O)(=O)Nc1cncc(n1)-c1ccc2nc(NC(C)=O)sc2c1
Show InChI InChI=1S/C20H17N5O4S2/c1-12(26)22-20-24-16-8-3-13(9-18(16)30-20)17-10-21-11-19(23-17)25-31(27,28)15-6-4-14(29-2)5-7-15/h3-11H,1-2H3,(H,23,25)(H,22,24,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 15n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of mTOR assessed as inhibition of 4EBP1 phosphorylation by TR-FRET assay


J Med Chem 54: 1789-811 (2011)


Article DOI: 10.1021/jm1014605
BindingDB Entry DOI: 10.7270/Q2TH8N1K
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM50343198
PNG
(CHEMBL1773600 | N-(6-(6-(4-Methoxyphenylsulfonamid...)
Show SMILES COc1ccc(cc1)S(=O)(=O)Nc1cncc(n1)-c1ccc2nc(NC(C)=O)sc2c1
Show InChI InChI=1S/C20H17N5O4S2/c1-12(26)22-20-24-16-8-3-13(9-18(16)30-20)17-10-21-11-19(23-17)25-31(27,28)15-6-4-14(29-2)5-7-15/h3-11H,1-2H3,(H,23,25)(H,22,24,26)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 739n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of AKT phosphorylation at S473 in human U-87MG cells at 5 mM after 2 hrs


J Med Chem 54: 1789-811 (2011)


Article DOI: 10.1021/jm1014605
BindingDB Entry DOI: 10.7270/Q2TH8N1K
More data for this
Ligand-Target Pair