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Compile Data Set for Download or QSAR

Found 1 hit of ic50 for monomerid = 50343216   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50343216
PNG
(CHEMBL1773583 | N-(6-(2-(Phenylthio)pyrimidin-4-yl...)
Show SMILES CC(=O)Nc1nc2ccc(cc2s1)-c1ccnc(Sc2ccccc2)n1
Show InChI InChI=1S/C19H14N4OS2/c1-12(24)21-19-23-16-8-7-13(11-17(16)26-19)15-9-10-20-18(22-15)25-14-5-3-2-4-6-14/h2-11H,1H3,(H,21,23,24)
PDB
MMDB

NCI pathway
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Article
PubMed
n/an/a>6.00E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of mTOR assessed as inhibition of 4EBP1 phosphorylation by TR-FRET assay

J Med Chem 54: 1789-811 (2011)


Article DOI: 10.1021/jm1014605
BindingDB Entry DOI: 10.7270/Q2TH8N1K
More data for this
Ligand-Target Pair