Found 8 hits of ic50 for monomerid = 50355679 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50355679
(CHEMBL1911114)Show SMILES COc1ccc2n(c(nc2c1O)C(F)F)-c1nc(nc(n1)N1CCOCC1)N1CCOCC1 Show InChI InChI=1S/C20H23F2N7O4/c1-31-13-3-2-12-14(15(13)30)23-17(16(21)22)29(12)20-25-18(27-4-8-32-9-5-27)24-19(26-20)28-6-10-33-11-7-28/h2-3,16,30H,4-11H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of human His-tagged PI3K p110delta after 2 hrs by HTRF assay |
J Med Chem 54: 7105-26 (2011)
Article DOI: 10.1021/jm200688y BindingDB Entry DOI: 10.7270/Q20P10FQ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50355679
(CHEMBL1911114)Show SMILES COc1ccc2n(c(nc2c1O)C(F)F)-c1nc(nc(n1)N1CCOCC1)N1CCOCC1 Show InChI InChI=1S/C20H23F2N7O4/c1-31-13-3-2-12-14(15(13)30)23-17(16(21)22)29(12)20-25-18(27-4-8-32-9-5-27)24-19(26-20)28-6-10-33-11-7-28/h2-3,16,30H,4-11H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.70 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PI3K p110beta expressed in Sf21 insect cells using phosphatidylinositol as substrate after 1 hr by phosphoimaging |
J Med Chem 54: 7105-26 (2011)
Article DOI: 10.1021/jm200688y BindingDB Entry DOI: 10.7270/Q20P10FQ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50355679
(CHEMBL1911114)Show SMILES COc1ccc2n(c(nc2c1O)C(F)F)-c1nc(nc(n1)N1CCOCC1)N1CCOCC1 Show InChI InChI=1S/C20H23F2N7O4/c1-31-13-3-2-12-14(15(13)30)23-17(16(21)22)29(12)20-25-18(27-4-8-32-9-5-27)24-19(26-20)28-6-10-33-11-7-28/h2-3,16,30H,4-11H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.70 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PI3K p110beta expressed in Sf21 insect cells using phosphatidylinositol as substrate after 1 hr by phosphoimaging |
J Med Chem 54: 7105-26 (2011)
Article DOI: 10.1021/jm200688y BindingDB Entry DOI: 10.7270/Q20P10FQ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Mus musculus (Mouse)) | BDBM50355679
(CHEMBL1911114)Show SMILES COc1ccc2n(c(nc2c1O)C(F)F)-c1nc(nc(n1)N1CCOCC1)N1CCOCC1 Show InChI InChI=1S/C20H23F2N7O4/c1-31-13-3-2-12-14(15(13)30)23-17(16(21)22)29(12)20-25-18(27-4-8-32-9-5-27)24-19(26-20)28-6-10-33-11-7-28/h2-3,16,30H,4-11H2,1H3 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of mouse recombinant PI3K p110alpha expressed in Sf21 insect cells using phosphatidylinositol as substrate after 1 hr by phosphoimaging |
J Med Chem 54: 7105-26 (2011)
Article DOI: 10.1021/jm200688y BindingDB Entry DOI: 10.7270/Q20P10FQ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50355679
(CHEMBL1911114)Show SMILES COc1ccc2n(c(nc2c1O)C(F)F)-c1nc(nc(n1)N1CCOCC1)N1CCOCC1 Show InChI InChI=1S/C20H23F2N7O4/c1-31-13-3-2-12-14(15(13)30)23-17(16(21)22)29(12)20-25-18(27-4-8-32-9-5-27)24-19(26-20)28-6-10-33-11-7-28/h2-3,16,30H,4-11H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of human His-tagged PI3K p110gamma after 2 hrs by HTRF assay |
J Med Chem 54: 7105-26 (2011)
Article DOI: 10.1021/jm200688y BindingDB Entry DOI: 10.7270/Q20P10FQ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50355679
(CHEMBL1911114)Show SMILES COc1ccc2n(c(nc2c1O)C(F)F)-c1nc(nc(n1)N1CCOCC1)N1CCOCC1 Show InChI InChI=1S/C20H23F2N7O4/c1-31-13-3-2-12-14(15(13)30)23-17(16(21)22)29(12)20-25-18(27-4-8-32-9-5-27)24-19(26-20)28-6-10-33-11-7-28/h2-3,16,30H,4-11H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of PIK3CA-mediated cell signaling in PTEN-deficient human U87MG cells assessed as inhibition of insulin-induced pAkt/PKB phosphorylation a... |
J Med Chem 54: 7105-26 (2011)
Article DOI: 10.1021/jm200688y BindingDB Entry DOI: 10.7270/Q20P10FQ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50355679
(CHEMBL1911114)Show SMILES COc1ccc2n(c(nc2c1O)C(F)F)-c1nc(nc(n1)N1CCOCC1)N1CCOCC1 Show InChI InChI=1S/C20H23F2N7O4/c1-31-13-3-2-12-14(15(13)30)23-17(16(21)22)29(12)20-25-18(27-4-8-32-9-5-27)24-19(26-20)28-6-10-33-11-7-28/h2-3,16,30H,4-11H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 378 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of PIK3CA-mediated cell signaling in PTEN-deficient human U87MG cells assessed as inhibition of insulin-induced pAkt/PKB phosphorylation a... |
J Med Chem 54: 7105-26 (2011)
Article DOI: 10.1021/jm200688y BindingDB Entry DOI: 10.7270/Q20P10FQ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50355679
(CHEMBL1911114)Show SMILES COc1ccc2n(c(nc2c1O)C(F)F)-c1nc(nc(n1)N1CCOCC1)N1CCOCC1 Show InChI InChI=1S/C20H23F2N7O4/c1-31-13-3-2-12-14(15(13)30)23-17(16(21)22)29(12)20-25-18(27-4-8-32-9-5-27)24-19(26-20)28-6-10-33-11-7-28/h2-3,16,30H,4-11H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 583 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of PIK3CA-mediated cell signaling in PTEN-deficient human U87MG cells assessed as inhibition of insulin-induced pAkt/PKB phosphorylation a... |
J Med Chem 54: 7105-26 (2011)
Article DOI: 10.1021/jm200688y BindingDB Entry DOI: 10.7270/Q20P10FQ |
More data for this Ligand-Target Pair | |