BindingDB PrimarySearch

Found 22 hits of ic50 for monomerid = 50370476
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50370476 (Combivir \| ZIDOVUDINE TRIPHOSPHATE) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem Similars	PDB PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Polish Academy of Sciences Curated by ChEMBL					Assay Description Tested against HIV-1 reverse transcriptase (HIV-1 RT) with poly(rA)/(dT)12-18 as template and [methyl-3H]-dTTP as competing substrate				J Med Chem 37: 3850-4 (1994) BindingDB Entry DOI: 10.7270/Q2PV6M05
Polish Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50370476 (Combivir \| ZIDOVUDINE TRIPHOSPHATE) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem Similars	PDB Article	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound concentration that causes 50 % inhibition of HIV-1 peptide-derived reverse transcriptase (RT) obtained from HIV-1-infected H9 cell cultures				Bioorg Med Chem Lett 1: 357-360 (1991) Article DOI: 10.1016/S0960-894X(01)80472-8 BindingDB Entry DOI: 10.7270/Q2PV6KVZ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50370476 (Combivir \| ZIDOVUDINE TRIPHOSPHATE) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem Similars	PDB Article	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory activity against HIV-1 reverse transcriptase				Bioorg Med Chem Lett 5: 2315-2320 (1995) Article DOI: 10.1016/0960-894X(95)00401-E BindingDB Entry DOI: 10.7270/Q2PG1S7P
TBA Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50370476 (Combivir \| ZIDOVUDINE TRIPHOSPHATE) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	54	n/a	n/a	n/a	n/a	n/a	n/a
Kagoshima University Curated by ChEMBL					Assay Description Inhibition of HIV1 recombinant reverse transcriptase				Antimicrob Agents Chemother 51: 2600-4 (2007) Article DOI: 10.1128/aac.00212-07 BindingDB Entry DOI: 10.7270/Q2XW4NKZ
Kagoshima University Curated by ChEMBL					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50370476 (Combivir \| ZIDOVUDINE TRIPHOSPHATE) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Inhibition of HIV1 LAI reverse transcriptase wild type LAI by heteropolymeric DNA polymerase assay				Antimicrob Agents Chemother 51: 2078-84 (2007) Article DOI: 10.1128/aac.00119-07 BindingDB Entry DOI: 10.7270/Q2H134SQ
Emory University Curated by ChEMBL					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50370476 (Combivir \| ZIDOVUDINE TRIPHOSPHATE) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Inhibition of HIV1 pNL4-3 reverse transcriptase wild type pNL4-3 by heteropolymeric DNA polymerase assay				Antimicrob Agents Chemother 51: 2078-84 (2007) Article DOI: 10.1128/aac.00119-07 BindingDB Entry DOI: 10.7270/Q2H134SQ
Emory University Curated by ChEMBL					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50370476 (Combivir \| ZIDOVUDINE TRIPHOSPHATE) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Inhibition of HIV1 LAI reverse transcriptase wild type in presence of 5 mM ATP by heteropolymeric DNA polymerase assay				Antimicrob Agents Chemother 51: 2078-84 (2007) Article DOI: 10.1128/aac.00119-07 BindingDB Entry DOI: 10.7270/Q2H134SQ
Emory University Curated by ChEMBL					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50370476 (Combivir \| ZIDOVUDINE TRIPHOSPHATE) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of HIV1 RT mediated DNA-dependent DNA synthesis initiation using RNA PPT primed substrate by scintillation proximity assay				J Biol Chem 282: 8005-10 (2007) Article DOI: 10.1074/jbc.m608274200 BindingDB Entry DOI: 10.7270/Q2PG1VH3
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50370476 (Combivir \| ZIDOVUDINE TRIPHOSPHATE) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of HIV1 RT mediated DNA-dependent DNA synthesis initiation using RNA/DNAM duplex primed substrate by scintillation proximity assay				J Biol Chem 282: 8005-10 (2007) Article DOI: 10.1074/jbc.m608274200 BindingDB Entry DOI: 10.7270/Q2PG1VH3
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50370476 (Combivir \| ZIDOVUDINE TRIPHOSPHATE) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	420	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Inhibition of HIV1 pNL4-3 reverse transcriptase wild type pNL4-3 in presence of 5 mM ATP by heteropolymeric DNA polymerase assay				Antimicrob Agents Chemother 51: 2078-84 (2007) Article DOI: 10.1128/aac.00119-07 BindingDB Entry DOI: 10.7270/Q2H134SQ
Emory University Curated by ChEMBL					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50370476 (Combivir \| ZIDOVUDINE TRIPHOSPHATE) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£t Konstanz Curated by ChEMBL					Assay Description Inhibitory concentration against human immunodeficiency virus type 1 reverse transcriptase				Bioorg Med Chem Lett 15: 869-71 (2005) Article DOI: 10.1016/j.bmcl.2004.12.072 BindingDB Entry DOI: 10.7270/Q2F190GP
Universit£t Konstanz Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
DNA polymerase delta catalytic subunit (Homo sapiens (Human))	BDBM50370476 (Combivir \| ZIDOVUDINE TRIPHOSPHATE) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	7.5	n/a
Pharmacia Corporation Curated by ChEMBL					Assay Description Inhibition of human delta DNA polymerase (95 uL) activity in a solution containg 6.4 mM HEPES (pH 7.5) upon incubation for 12 minutes at 26 degrees C...				J Med Chem 48: 5794-804 (2005) Article DOI: 10.1021/jm050162b BindingDB Entry DOI: 10.7270/Q2G44R39
Pharmacia Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
DNA polymerase catalytic subunit (Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)	BDBM50370476 (Combivir \| ZIDOVUDINE TRIPHOSPHATE) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	7.5	n/a
Pharmacia Corporation Curated by ChEMBL					Assay Description Inhibition of herpes simplex virus type 1 DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes a...				J Med Chem 48: 5794-804 (2005) Article DOI: 10.1021/jm050162b BindingDB Entry DOI: 10.7270/Q2G44R39
Pharmacia Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
DNA polymerase catalytic subunit (Human herpesvirus 1 (strain KOS) (HHV-1) (Human he...)	BDBM50370476 (Combivir \| ZIDOVUDINE TRIPHOSPHATE) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of HSV1 DNA polymerase by scintillation proximity assay				Bioorg Med Chem Lett 18: 3856-9 (2008) Article DOI: 10.1016/j.bmcl.2008.06.060 BindingDB Entry DOI: 10.7270/Q2RB75HB
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
DNA polymerase catalytic subunit (Varicella-zoster virus (strain Dumas) (HHV-3) (Hum...)	BDBM50370476 (Combivir \| ZIDOVUDINE TRIPHOSPHATE) Show SMILES Show InChI	UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	5.80E+3	n/a	n/a	n/a	n/a	7.5	n/a
Pharmacia Corporation Curated by ChEMBL					Assay Description Inhibition of Varicella-Zoster virus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 ...				J Med Chem 48: 5794-804 (2005) Article DOI: 10.1021/jm050162b BindingDB Entry DOI: 10.7270/Q2G44R39
Pharmacia Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
DNA polymerase catalytic subunit (Varicella-zoster virus (strain Dumas) (HHV-3) (Hum...)	BDBM50370476 (Combivir \| ZIDOVUDINE TRIPHOSPHATE) Show SMILES Show InChI	UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	5.80E+3	n/a	n/a	n/a	n/a	7.5	n/a
Pharmacia Corporation Curated by ChEMBL					Assay Description Inhibition of Varicella-Zoster virus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 ...				J Med Chem 48: 5794-804 (2005) Article DOI: 10.1021/jm050162b BindingDB Entry DOI: 10.7270/Q2G44R39
Pharmacia Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50370476 (Combivir \| ZIDOVUDINE TRIPHOSPHATE) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Saarland University Curated by ChEMBL					Assay Description Inhibition of HIV1 reverse transcriptase using T19-Cy5 labeled 23-mer DNA/T2-TAMRA labeled 63-mer DNA as primer/template assessed as inhibition of dN...				J Med Chem 59: 7212-22 (2016) Article DOI: 10.1021/acs.jmedchem.6b00730 BindingDB Entry DOI: 10.7270/Q27M0CFC
Saarland University Curated by ChEMBL					More data for this Ligand-Target Pair
DNA polymerase alpha catalytic subunit (Homo sapiens (Human))	BDBM50370476 (Combivir \| ZIDOVUDINE TRIPHOSPHATE) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chulalongkorn University Curated by ChEMBL					Assay Description Inhibition of DNA polymerase alpha				J Nat Prod 59: 839-42 (1997) Article DOI: 10.1021/np960399y BindingDB Entry DOI: 10.7270/Q20C4WPN
Chulalongkorn University Curated by ChEMBL					More data for this Ligand-Target Pair
DNA polymerase alpha catalytic subunit (Homo sapiens (Human))	BDBM50370476 (Combivir \| ZIDOVUDINE TRIPHOSPHATE) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.34E+4	n/a	n/a	n/a	n/a	7.5	n/a
Pharmacia Corporation Curated by ChEMBL					Assay Description Inhibition of human alpha DNA polymerase (95 uL) activity in a solution containg 6.4 mM HEPES (pH 7.5) upon incubation for 12 minutes at 26 degrees C...				J Med Chem 48: 5794-804 (2005) Article DOI: 10.1021/jm050162b BindingDB Entry DOI: 10.7270/Q2G44R39
Pharmacia Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
DNA polymerase beta (Homo sapiens (Human))	BDBM50370476 (Combivir \| ZIDOVUDINE TRIPHOSPHATE) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chulalongkorn University Curated by ChEMBL					Assay Description Inhibition of DNA polymerase beta				J Nat Prod 59: 839-42 (1997) Article DOI: 10.1021/np960399y BindingDB Entry DOI: 10.7270/Q20C4WPN
Chulalongkorn University Curated by ChEMBL					More data for this Ligand-Target Pair
DNA polymerase catalytic subunit (Human cytomegalovirus (HCMV strain AD169) )	BDBM50370476 (Combivir \| ZIDOVUDINE TRIPHOSPHATE) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.21E+4	n/a	n/a	n/a	n/a	7.5	n/a
Pharmacia Corporation Curated by ChEMBL					Assay Description Inhibition of human cytomegalovirus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 d...				J Med Chem 48: 5794-804 (2005) Article DOI: 10.1021/jm050162b BindingDB Entry DOI: 10.7270/Q2G44R39
Pharmacia Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
DNA polymerase catalytic subunit (Human cytomegalovirus (HCMV strain AD169) )	BDBM50370476 (Combivir \| ZIDOVUDINE TRIPHOSPHATE) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.21E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of HCMV DNA polymerase by scintillation proximity assay				Bioorg Med Chem Lett 17: 3349-53 (2007) Article DOI: 10.1016/j.bmcl.2007.03.102 BindingDB Entry DOI: 10.7270/Q2HX1DHN
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair