Found 2 hits of ic50 for monomerid = 50378296 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/G1/S-specific cyclin-E2
(Homo sapiens (Human)) | BDBM50378296
(CHEMBL568510)Show SMILES CC(C)n1cnc2c(NCc3csc(c3)-c3ccccc3)nc(N[C@H]3CC[C@H](N)CC3)nc12 |r,wU:24.25,wD:27.29,(28.27,-15.16,;29.29,-14.01,;30.8,-14.32,;28.8,-12.55,;29.7,-11.3,;28.78,-10.06,;27.33,-10.55,;25.99,-9.79,;25.99,-8.25,;24.65,-7.49,;23.32,-8.27,;21.91,-7.66,;20.89,-8.81,;21.66,-10.14,;23.17,-9.81,;20.91,-11.47,;19.37,-11.49,;18.62,-12.83,;19.4,-14.16,;20.95,-14.13,;21.7,-12.79,;24.66,-10.57,;24.67,-12.11,;23.34,-12.88,;23.34,-14.42,;24.68,-15.18,;24.68,-16.73,;23.34,-17.5,;23.34,-19.04,;22.01,-16.73,;22,-15.2,;26.01,-12.87,;27.34,-12.09,)| Show InChI InChI=1S/C25H31N7S/c1-16(2)32-15-28-22-23(27-13-17-12-21(33-14-17)18-6-4-3-5-7-18)30-25(31-24(22)32)29-20-10-8-19(26)9-11-20/h3-7,12,14-16,19-20H,8-11,13,26H2,1-2H3,(H2,27,29,30,31)/t19-,20- | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.0900 | n/a | n/a | n/a | n/a | n/a | n/a |
AMRI
Curated by ChEMBL
| Assay Description Inhibition of Cdk2/cyclinE |
Bioorg Med Chem Lett 19: 6613-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.011 BindingDB Entry DOI: 10.7270/Q2M32WPQ |
More data for this Ligand-Target Pair | |
Cyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50378296
(CHEMBL568510)Show SMILES CC(C)n1cnc2c(NCc3csc(c3)-c3ccccc3)nc(N[C@H]3CC[C@H](N)CC3)nc12 |r,wU:24.25,wD:27.29,(28.27,-15.16,;29.29,-14.01,;30.8,-14.32,;28.8,-12.55,;29.7,-11.3,;28.78,-10.06,;27.33,-10.55,;25.99,-9.79,;25.99,-8.25,;24.65,-7.49,;23.32,-8.27,;21.91,-7.66,;20.89,-8.81,;21.66,-10.14,;23.17,-9.81,;20.91,-11.47,;19.37,-11.49,;18.62,-12.83,;19.4,-14.16,;20.95,-14.13,;21.7,-12.79,;24.66,-10.57,;24.67,-12.11,;23.34,-12.88,;23.34,-14.42,;24.68,-15.18,;24.68,-16.73,;23.34,-17.5,;23.34,-19.04,;22.01,-16.73,;22,-15.2,;26.01,-12.87,;27.34,-12.09,)| Show InChI InChI=1S/C25H31N7S/c1-16(2)32-15-28-22-23(27-13-17-12-21(33-14-17)18-6-4-3-5-7-18)30-25(31-24(22)32)29-20-10-8-19(26)9-11-20/h3-7,12,14-16,19-20H,8-11,13,26H2,1-2H3,(H2,27,29,30,31)/t19-,20- | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a |
AMRI
Curated by ChEMBL
| Assay Description Inhibition of recombinant Cdk2/cyclinA |
Bioorg Med Chem Lett 19: 6613-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.011 BindingDB Entry DOI: 10.7270/Q2M32WPQ |
More data for this Ligand-Target Pair | |