Found 3 hits of ic50 for monomerid = 50379496 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Aurora kinase B
(Homo sapiens (Human)) | BDBM50379496
(CHEMBL2012408)Show SMILES Cn1cc(Nc2ncc3cnn([C@H]4C[C@@H]5C[C@@H]5C4)c3n2)cc1C(=O)N1CCC[C@H]1C(N)=O |r| Show InChI InChI=1S/C22H26N8O2/c1-28-11-15(8-18(28)21(32)29-4-2-3-17(29)19(23)31)26-22-24-9-14-10-25-30(20(14)27-22)16-6-12-5-13(12)7-16/h8-13,16-17H,2-7H2,1H3,(H2,23,31)(H,24,26,27)/t12-,13+,16-,17-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Biogen Idec Inc.
Curated by ChEMBL
| Assay Description Inhibition of aurora B kinase |
Bioorg Med Chem Lett 22: 2070-4 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.019 BindingDB Entry DOI: 10.7270/Q2833T1N |
More data for this Ligand-Target Pair | |
Aurora kinase A
(Homo sapiens (Human)) | BDBM50379496
(CHEMBL2012408)Show SMILES Cn1cc(Nc2ncc3cnn([C@H]4C[C@@H]5C[C@@H]5C4)c3n2)cc1C(=O)N1CCC[C@H]1C(N)=O |r| Show InChI InChI=1S/C22H26N8O2/c1-28-11-15(8-18(28)21(32)29-4-2-3-17(29)19(23)31)26-22-24-9-14-10-25-30(20(14)27-22)16-6-12-5-13(12)7-16/h8-13,16-17H,2-7H2,1H3,(H2,23,31)(H,24,26,27)/t12-,13+,16-,17-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Biogen Idec Inc.
Curated by ChEMBL
| Assay Description Inhibition of aurora A kinase |
Bioorg Med Chem Lett 22: 2070-4 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.019 BindingDB Entry DOI: 10.7270/Q2833T1N |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (Human)) | BDBM50379496
(CHEMBL2012408)Show SMILES Cn1cc(Nc2ncc3cnn([C@H]4C[C@@H]5C[C@@H]5C4)c3n2)cc1C(=O)N1CCC[C@H]1C(N)=O |r| Show InChI InChI=1S/C22H26N8O2/c1-28-11-15(8-18(28)21(32)29-4-2-3-17(29)19(23)31)26-22-24-9-14-10-25-30(20(14)27-22)16-6-12-5-13(12)7-16/h8-13,16-17H,2-7H2,1H3,(H2,23,31)(H,24,26,27)/t12-,13+,16-,17-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Biogen Idec Inc.
Curated by ChEMBL
| Assay Description Inhibition of CDK1 |
Bioorg Med Chem Lett 22: 2070-4 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.019 BindingDB Entry DOI: 10.7270/Q2833T1N |
More data for this Ligand-Target Pair | |