Found 7 hits of ic50 for monomerid = 50385785 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50385785
(CHEMBL2041172)Show SMILES COc1cc(ncn1)N1C(=O)N(C(=O)C11CCN(Cc2ncccc2C)CC1)c1ccc(cc1)-c1ccc2cn[nH]c2c1 Show InChI InChI=1S/C32H30N8O3/c1-21-4-3-13-33-27(21)19-38-14-11-32(12-15-38)30(41)39(31(42)40(32)28-17-29(43-2)35-20-34-28)25-9-7-22(8-10-25)23-5-6-24-18-36-37-26(24)16-23/h3-10,13,16-18,20H,11-12,14-15,19H2,1-2H3,(H,36,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of FLAG-tagged PHD2 expressed in baculovirus infected insect sf9 cells using biotinyl-DLDLEMLAPYIPMDDDFQL as substrate preincubated with c... |
J Med Chem 55: 2945-59 (2012)
Article DOI: 10.1021/jm201542d
BindingDB Entry DOI: 10.7270/Q27945QW |
More data for this
Ligand-Target Pair | |
Prolyl hydroxylase EGLN2
(Homo sapiens (Human)) | BDBM50385785
(CHEMBL2041172)Show SMILES COc1cc(ncn1)N1C(=O)N(C(=O)C11CCN(Cc2ncccc2C)CC1)c1ccc(cc1)-c1ccc2cn[nH]c2c1 Show InChI InChI=1S/C32H30N8O3/c1-21-4-3-13-33-27(21)19-38-14-11-32(12-15-38)30(41)39(31(42)40(32)28-17-29(43-2)35-20-34-28)25-9-7-22(8-10-25)23-5-6-24-18-36-37-26(24)16-23/h3-10,13,16-18,20H,11-12,14-15,19H2,1-2H3,(H,36,37) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of PHD1 |
J Med Chem 55: 2945-59 (2012)
Article DOI: 10.1021/jm201542d
BindingDB Entry DOI: 10.7270/Q27945QW |
More data for this
Ligand-Target Pair | |
Prolyl hydroxylase EGLN3
(Homo sapiens (Human)) | BDBM50385785
(CHEMBL2041172)Show SMILES COc1cc(ncn1)N1C(=O)N(C(=O)C11CCN(Cc2ncccc2C)CC1)c1ccc(cc1)-c1ccc2cn[nH]c2c1 Show InChI InChI=1S/C32H30N8O3/c1-21-4-3-13-33-27(21)19-38-14-11-32(12-15-38)30(41)39(31(42)40(32)28-17-29(43-2)35-20-34-28)25-9-7-22(8-10-25)23-5-6-24-18-36-37-26(24)16-23/h3-10,13,16-18,20H,11-12,14-15,19H2,1-2H3,(H,36,37) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of PHD3 |
J Med Chem 55: 2945-59 (2012)
Article DOI: 10.1021/jm201542d
BindingDB Entry DOI: 10.7270/Q27945QW |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50385785
(CHEMBL2041172)Show SMILES COc1cc(ncn1)N1C(=O)N(C(=O)C11CCN(Cc2ncccc2C)CC1)c1ccc(cc1)-c1ccc2cn[nH]c2c1 Show InChI InChI=1S/C32H30N8O3/c1-21-4-3-13-33-27(21)19-38-14-11-32(12-15-38)30(41)39(31(42)40(32)28-17-29(43-2)35-20-34-28)25-9-7-22(8-10-25)23-5-6-24-18-36-37-26(24)16-23/h3-10,13,16-18,20H,11-12,14-15,19H2,1-2H3,(H,36,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 720 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human Erg |
J Med Chem 55: 2945-59 (2012)
Article DOI: 10.1021/jm201542d
BindingDB Entry DOI: 10.7270/Q27945QW |
More data for this
Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50385785
(CHEMBL2041172)Show SMILES COc1cc(ncn1)N1C(=O)N(C(=O)C11CCN(Cc2ncccc2C)CC1)c1ccc(cc1)-c1ccc2cn[nH]c2c1 Show InChI InChI=1S/C32H30N8O3/c1-21-4-3-13-33-27(21)19-38-14-11-32(12-15-38)30(41)39(31(42)40(32)28-17-29(43-2)35-20-34-28)25-9-7-22(8-10-25)23-5-6-24-18-36-37-26(24)16-23/h3-10,13,16-18,20H,11-12,14-15,19H2,1-2H3,(H,36,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of CYP3A4 |
J Med Chem 55: 2945-59 (2012)
Article DOI: 10.1021/jm201542d
BindingDB Entry DOI: 10.7270/Q27945QW |
More data for this
Ligand-Target Pair | |
Cytochrome P450 2D6
(Homo sapiens (Human)) | BDBM50385785
(CHEMBL2041172)Show SMILES COc1cc(ncn1)N1C(=O)N(C(=O)C11CCN(Cc2ncccc2C)CC1)c1ccc(cc1)-c1ccc2cn[nH]c2c1 Show InChI InChI=1S/C32H30N8O3/c1-21-4-3-13-33-27(21)19-38-14-11-32(12-15-38)30(41)39(31(42)40(32)28-17-29(43-2)35-20-34-28)25-9-7-22(8-10-25)23-5-6-24-18-36-37-26(24)16-23/h3-10,13,16-18,20H,11-12,14-15,19H2,1-2H3,(H,36,37) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of CYP2D6 |
J Med Chem 55: 2945-59 (2012)
Article DOI: 10.1021/jm201542d
BindingDB Entry DOI: 10.7270/Q27945QW |
More data for this
Ligand-Target Pair | |
Cytochrome P450 2C9
(Homo sapiens (Human)) | BDBM50385785
(CHEMBL2041172)Show SMILES COc1cc(ncn1)N1C(=O)N(C(=O)C11CCN(Cc2ncccc2C)CC1)c1ccc(cc1)-c1ccc2cn[nH]c2c1 Show InChI InChI=1S/C32H30N8O3/c1-21-4-3-13-33-27(21)19-38-14-11-32(12-15-38)30(41)39(31(42)40(32)28-17-29(43-2)35-20-34-28)25-9-7-22(8-10-25)23-5-6-24-18-36-37-26(24)16-23/h3-10,13,16-18,20H,11-12,14-15,19H2,1-2H3,(H,36,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of CYP2C9 |
J Med Chem 55: 2945-59 (2012)
Article DOI: 10.1021/jm201542d
BindingDB Entry DOI: 10.7270/Q27945QW |
More data for this
Ligand-Target Pair | |
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