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Compile Data Set for Download or QSAR

Found 5 hits of ic50 for monomerid = 50393349   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50393349
PNG
(CHEMBL2152140)
Show SMILES CNC(=O)c1nc(cnc1N)-c1ccc(Cl)c(c1)S(=O)(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C19H18ClN5O3S/c1-11-4-3-5-13(8-11)25-29(27,28)16-9-12(6-7-14(16)20)15-10-23-18(21)17(24-15)19(26)22-2/h3-10,25H,1-2H3,(H2,21,23)(H,22,26)
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n/an/a 48n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma expressed in sf9 cells assessed as amount of ATP consumed by luciferase-luciferin chemiluminescence assay


J Med Chem 55: 5467-82 (2012)


Article DOI: 10.1021/jm300403a
BindingDB Entry DOI: 10.7270/Q2DF6S9N
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50393349
PNG
(CHEMBL2152140)
Show SMILES CNC(=O)c1nc(cnc1N)-c1ccc(Cl)c(c1)S(=O)(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C19H18ClN5O3S/c1-11-4-3-5-13(8-11)25-29(27,28)16-9-12(6-7-14(16)20)15-10-23-18(21)17(24-15)19(26)22-2/h3-10,25H,1-2H3,(H2,21,23)(H,22,26)
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n/an/a 323n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kalpha expressed in sf9 cells coexpressing p85alpha assessed as amount of ATP consumed by luciferase-luciferin chemiluminescen...


J Med Chem 55: 5467-82 (2012)


Article DOI: 10.1021/jm300403a
BindingDB Entry DOI: 10.7270/Q2DF6S9N
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50393349
PNG
(CHEMBL2152140)
Show SMILES CNC(=O)c1nc(cnc1N)-c1ccc(Cl)c(c1)S(=O)(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C19H18ClN5O3S/c1-11-4-3-5-13(8-11)25-29(27,28)16-9-12(6-7-14(16)20)15-10-23-18(21)17(24-15)19(26)22-2/h3-10,25H,1-2H3,(H2,21,23)(H,22,26)
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n/an/a 568n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kdelta expressed in sf9 cells coexpressing p85alpha assessed as amount of ATP consumed by luciferase-luciferin chemiluminescen...


J Med Chem 55: 5467-82 (2012)


Article DOI: 10.1021/jm300403a
BindingDB Entry DOI: 10.7270/Q2DF6S9N
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50393349
PNG
(CHEMBL2152140)
Show SMILES CNC(=O)c1nc(cnc1N)-c1ccc(Cl)c(c1)S(=O)(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C19H18ClN5O3S/c1-11-4-3-5-13(8-11)25-29(27,28)16-9-12(6-7-14(16)20)15-10-23-18(21)17(24-15)19(26)22-2/h3-10,25H,1-2H3,(H2,21,23)(H,22,26)
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n/an/a 572n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma expressed in C5a-stimulated mouse RAW 264.7 cells assessed as inhibition of AKT phosphorylation by ELISA


J Med Chem 55: 5467-82 (2012)


Article DOI: 10.1021/jm300403a
BindingDB Entry DOI: 10.7270/Q2DF6S9N
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50393349
PNG
(CHEMBL2152140)
Show SMILES CNC(=O)c1nc(cnc1N)-c1ccc(Cl)c(c1)S(=O)(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C19H18ClN5O3S/c1-11-4-3-5-13(8-11)25-29(27,28)16-9-12(6-7-14(16)20)15-10-23-18(21)17(24-15)19(26)22-2/h3-10,25H,1-2H3,(H2,21,23)(H,22,26)
PDB
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n/an/a 2.08E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta expressed in sf9 cells coexpressing p85alpha assessed as amount of ATP consumed by luciferase-luciferin chemiluminescenc...


J Med Chem 55: 5467-82 (2012)


Article DOI: 10.1021/jm300403a
BindingDB Entry DOI: 10.7270/Q2DF6S9N
More data for this
Ligand-Target Pair