BindingDB PrimarySearch

Found 5 hits of ic50 for monomerid = 50418610
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50418610 (GW-856553 \| GW856553X \| LOSMAPIMOD \| US10550073, C...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25.1	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of p38alpha-dependent TNFalpha production in human whole blood preincubated for 1 hr before LPS challenge by ELISA				J Med Chem 52: 6257-69 (2009) Article DOI: 10.1021/jm9004779 BindingDB Entry DOI: 10.7270/Q2J967NC
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50418610 (GW-856553 \| GW856553X \| LOSMAPIMOD \| US10550073, C...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of p38alpha-dependent TNFalpha production in human PBMC preincubated for 1 hr before LPS challenge by ELISA				J Med Chem 52: 6257-69 (2009) Article DOI: 10.1021/jm9004779 BindingDB Entry DOI: 10.7270/Q2J967NC
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50418610 (GW-856553 \| GW856553X \| LOSMAPIMOD \| US10550073, C...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. US Patent					Assay Description Experimental Method: 40 nM p38a was added into a reaction buffer, which include 20 mM HEPES (4-hydroxyethylpiperazine ethanesulfonic acid), 5 mM MgCl...				US Patent US10550073 (2020) BindingDB Entry DOI: 10.7270/Q21R6SWZ
					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM50418610 (GW-856553 \| GW856553X \| LOSMAPIMOD \| US10550073, C...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. US Patent					Assay Description Experimental Method: 4-hydroxydiclofenac (the substrate for CYP450 and 2C9 enzymes) and different doses of compounds were added into human liver micr...				US Patent US10550073 (2020) BindingDB Entry DOI: 10.7270/Q21R6SWZ
					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM50418610 (GW-856553 \| GW856553X \| LOSMAPIMOD \| US10550073, C...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.16E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of human CYP2C9 expressed in Escherichia coli by fluorimetric assay				J Med Chem 52: 6257-69 (2009) Article DOI: 10.1021/jm9004779 BindingDB Entry DOI: 10.7270/Q2J967NC
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair