Found 3 hits of ic50 for monomerid = 50448705 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50448705
(CHEMBL3127855)Show SMILES COCCOc1nc([C@H]2CCCO2)c(s1)C(=O)NC1C2CC3CC1CC(O)(C3)C2 |r,wD:8.7,TLB:17:18:22:24.25.27,28:25:18.19.20:22,THB:28:19:22:24.25.27,27:25:18:20.21.22,27:21:18:24.28.25,26:25:18:20.21.22,26:25:18.19.20:22,(13.52,-30.59,;14.98,-31.09,;16.14,-30.08,;17.6,-30.58,;18.76,-29.57,;20.21,-30.07,;20.66,-31.54,;22.2,-31.57,;23.09,-32.83,;22.6,-34.28,;23.83,-35.2,;25.09,-34.32,;24.64,-32.85,;22.7,-30.11,;21.47,-29.18,;24.03,-29.33,;24.03,-27.79,;25.37,-30.1,;26.7,-29.32,;28.2,-28.94,;28.22,-27.34,;29.29,-26.13,;27.93,-26.58,;27.92,-28.07,;29.23,-28.58,;30.64,-28.26,;32.18,-28.23,;30.68,-26.73,;29.6,-29.52,)| Show InChI InChI=1S/C21H30N2O5S/c1-26-5-6-28-20-23-17(15-3-2-4-27-15)18(29-20)19(24)22-16-13-7-12-8-14(16)11-21(25,9-12)10-13/h12-16,25H,2-11H2,1H3,(H,22,24)/t12?,13?,14?,15-,16?,21?/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.490 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of recombinant human 11beta-HSD1 using cortisone/[3H]-cortisone as substrate after 5 hrs by reverse-phase HPLC analysis |
J Med Chem 57: 970-86 (2014)
Article DOI: 10.1021/jm4016729 BindingDB Entry DOI: 10.7270/Q2Z32149 |
More data for this Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Mus musculus (mouse)) | BDBM50448705
(CHEMBL3127855)Show SMILES COCCOc1nc([C@H]2CCCO2)c(s1)C(=O)NC1C2CC3CC1CC(O)(C3)C2 |r,wD:8.7,TLB:17:18:22:24.25.27,28:25:18.19.20:22,THB:28:19:22:24.25.27,27:25:18:20.21.22,27:21:18:24.28.25,26:25:18:20.21.22,26:25:18.19.20:22,(13.52,-30.59,;14.98,-31.09,;16.14,-30.08,;17.6,-30.58,;18.76,-29.57,;20.21,-30.07,;20.66,-31.54,;22.2,-31.57,;23.09,-32.83,;22.6,-34.28,;23.83,-35.2,;25.09,-34.32,;24.64,-32.85,;22.7,-30.11,;21.47,-29.18,;24.03,-29.33,;24.03,-27.79,;25.37,-30.1,;26.7,-29.32,;28.2,-28.94,;28.22,-27.34,;29.29,-26.13,;27.93,-26.58,;27.92,-28.07,;29.23,-28.58,;30.64,-28.26,;32.18,-28.23,;30.68,-26.73,;29.6,-29.52,)| Show InChI InChI=1S/C21H30N2O5S/c1-26-5-6-28-20-23-17(15-3-2-4-27-15)18(29-20)19(24)22-16-13-7-12-8-14(16)11-21(25,9-12)10-13/h12-16,25H,2-11H2,1H3,(H,22,24)/t12?,13?,14?,15-,16?,21?/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.90 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of N-terminal 6-His-tagged full-length mouse 11beta-HSD1 assessed as conversion of cortisone to cortisol after 25 mins by competitive HTRF... |
J Med Chem 57: 970-86 (2014)
Article DOI: 10.1021/jm4016729 BindingDB Entry DOI: 10.7270/Q2Z32149 |
More data for this Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50448705
(CHEMBL3127855)Show SMILES COCCOc1nc([C@H]2CCCO2)c(s1)C(=O)NC1C2CC3CC1CC(O)(C3)C2 |r,wD:8.7,TLB:17:18:22:24.25.27,28:25:18.19.20:22,THB:28:19:22:24.25.27,27:25:18:20.21.22,27:21:18:24.28.25,26:25:18:20.21.22,26:25:18.19.20:22,(13.52,-30.59,;14.98,-31.09,;16.14,-30.08,;17.6,-30.58,;18.76,-29.57,;20.21,-30.07,;20.66,-31.54,;22.2,-31.57,;23.09,-32.83,;22.6,-34.28,;23.83,-35.2,;25.09,-34.32,;24.64,-32.85,;22.7,-30.11,;21.47,-29.18,;24.03,-29.33,;24.03,-27.79,;25.37,-30.1,;26.7,-29.32,;28.2,-28.94,;28.22,-27.34,;29.29,-26.13,;27.93,-26.58,;27.92,-28.07,;29.23,-28.58,;30.64,-28.26,;32.18,-28.23,;30.68,-26.73,;29.6,-29.52,)| Show InChI InChI=1S/C21H30N2O5S/c1-26-5-6-28-20-23-17(15-3-2-4-27-15)18(29-20)19(24)22-16-13-7-12-8-14(16)11-21(25,9-12)10-13/h12-16,25H,2-11H2,1H3,(H,22,24)/t12?,13?,14?,15-,16?,21?/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of N-terminal 6-His-tagged full-length human 11beta-HSD1 assessed as conversion of cortisone to cortisol after 25 mins by competitive HTRF... |
J Med Chem 57: 970-86 (2014)
Article DOI: 10.1021/jm4016729 BindingDB Entry DOI: 10.7270/Q2Z32149 |
More data for this Ligand-Target Pair | |