Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM60589 (6-{[6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Southeast University Curated by ChEMBL | Assay Description Inhibition of c-Met (unknown origin) incubated for 1 hr by spectrophotometric analysis | Bioorg Med Chem 24: 3483-93 (2016) Article DOI: 10.1016/j.bmc.2016.05.057 BindingDB Entry DOI: 10.7270/Q29G5PQT | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Isoform 2 of Hepatocyte growth factor receptor (2) (Homo sapiens (Human)) | BDBM60589 (6-{[6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Tianjin University of Science and Technology | Assay Description The c-Met kinase activity of five target compounds and three positive compounds were evaluated using standard Z-LYTE Assays (fluorescence resonance e... | Bioorg Chem 65: 146-58 (2016) Article DOI: 10.1016/j.bioorg.2016.02.009 BindingDB Entry DOI: 10.7270/Q2VT1QVX | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM60589 (6-{[6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica Curated by ChEMBL | Assay Description Inhibition of C-Met (unknown origin) using polu (Glu,Tyr)4:1 substrate after 30 mins incubation by multi-well spectrophotometry | ACS Med Chem Lett 6: 507-12 (2015) Article DOI: 10.1021/ml5004876 BindingDB Entry DOI: 10.7270/Q2QV3P79 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM60589 (6-{[6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of c-Met (unknown origin) | Eur J Med Chem 108: 495-504 (2016) Article DOI: 10.1016/j.ejmech.2015.12.016 BindingDB Entry DOI: 10.7270/Q2G73GMC | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM60589 (6-{[6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-F... | US Patent US9062045 (2015) BindingDB Entry DOI: 10.7270/Q23F4NDS | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human)) | BDBM60589 (6-{[6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-F... | US Patent US9062045 (2015) BindingDB Entry DOI: 10.7270/Q23F4NDS | |||||||||||
More data for this Ligand-Target Pair |