Found 56 hits of ic50 for monomerid = 9460 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank Article PubMed
| n/a | n/a | 5.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Johns Hopkins University
Curated by ChEMBL
| Assay Description Inhibition of human placental microsome CYP19 |
Bioorg Med Chem Lett 20: 3050-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.113 BindingDB Entry DOI: 10.7270/Q2CJ8FFS |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank Article PubMed
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description Inhibition of human aromatase |
J Med Chem 50: 2799-806 (2007)
Article DOI: 10.1021/jm070109i BindingDB Entry DOI: 10.7270/Q2668F0Z |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
Reactome pathway KEGG
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| DrugBank Article PubMed
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
| Assay Description Aromatase inhibition was quantified by measuring the fluorescent intensity of fluorescein, the hydrolysis product of dibenzylfluorescein (DBF), by ar... |
J Med Chem 52: 1873-84 (2009)
Article DOI: 10.1021/jm801335z BindingDB Entry DOI: 10.7270/Q2NP22RV |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
Reactome pathway KEGG
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| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CIBA-GEIGY Corporation
Curated by ChEMBL
| Assay Description Inhibition of human placental microsome cytochrome P450 19A1 |
J Med Chem 34: 725-36 (1991)
BindingDB Entry DOI: 10.7270/Q2SB46BP |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
Reactome pathway KEGG
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| DrugBank PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CIBA-GEIGY Ltd
Curated by ChEMBL
| Assay Description In vitro inhibition of human placental Cytochrome P450 19A1 |
J Med Chem 36: 1393-400 (1993)
BindingDB Entry DOI: 10.7270/Q2ZK5FR9 |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
Reactome pathway KEGG
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| DrugBank PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CIBA-GEIGY AG.
Curated by ChEMBL
| Assay Description In vitro inhibition of cytochrome P450 19A1 Aromatase |
J Med Chem 34: 1329-34 (1991)
BindingDB Entry DOI: 10.7270/Q2QN65RW |
More data for this Ligand-Target Pair | |
Replicase polyprotein 1ab
(2019-nCoV) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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| | n/a | n/a | 1.91E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
Reactome pathway KEGG
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| DrugBank Article PubMed
| 1.41E+3 | -34.7 | 2.80E+3 | n/a | n/a | n/a | n/a | 7.0 | 37 |
Ohio State University
| Assay Description Inhibition of human placental aromatase was determined by monitoring the amount of 3H2O released as the enzyme converts [1beta-3H]androst-4-ene-3,17-... |
Bioorg Med Chem 13: 4063-70 (2005)
Article DOI: 10.1016/j.bmc.2005.03.050 BindingDB Entry DOI: 10.7270/Q2TB154R |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
Reactome pathway KEGG
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| DrugBank Article PubMed
| 1.41E+3 | -34.7 | 2.80E+3 | n/a | n/a | n/a | n/a | 7.0 | 37 |
Ohio State University
| Assay Description Inhibition of human placental aromatase was determined by monitoring the amount of 3H2O released as the enzyme converts [1beta-3H]androst-4-ene-3,17-... |
J Med Chem 47: 4032-40 (2004)
Article DOI: 10.1021/jm0306024 BindingDB Entry DOI: 10.7270/Q2RJ4GP7 |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
Reactome pathway KEGG
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| DrugBank Article PubMed
| 1.41E+3 | -34.7 | 2.80E+3 | n/a | n/a | n/a | n/a | 7.0 | 37 |
Ohio State University
| Assay Description Inhibition of human placental aromatase was determined by monitoring the amount of 3H2O released as the enzyme converts [1beta-3H]androst-4-ene-3,17-... |
Bioorg Med Chem 13: 6571-7 (2005)
Article DOI: 10.1016/j.bmc.2005.07.038 BindingDB Entry DOI: 10.7270/Q2PK0DCK |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank PubMed
| n/a | n/a | 5.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UPRES EA 1085
Curated by ChEMBL
| Assay Description In vitro inhibition of [1,2,6,7-3H]-androstenedione binding to human placental microsome cytochrome P450 19A1 |
Bioorg Med Chem Lett 12: 1059-61 (2002)
BindingDB Entry DOI: 10.7270/Q2125S01 |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank PubMed
| n/a | n/a | 5.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UPRES EA 1085
Curated by ChEMBL
| Assay Description Inhibition of aromatase activity in human placental microsomes |
Bioorg Med Chem Lett 12: 2859-61 (2002)
BindingDB Entry DOI: 10.7270/Q2PK0FHS |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
Reactome pathway KEGG
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| DrugBank Article PubMed
| n/a | n/a | 5.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UPRES EA 4021 Biomol�cules et Th�rapies anti-tumorales
Curated by ChEMBL
| Assay Description Inhibition of aromatase in human placental microsomes assessed as inhibition of aromatization of [1,2,6,7-3H] androstenedione by flow scintillation a... |
Eur J Med Chem 46: 2541-5 (2011)
Article DOI: 10.1016/j.ejmech.2011.03.043 BindingDB Entry DOI: 10.7270/Q2MC90CB |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank PubMed
| n/a | n/a | 6.13E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Cytochrome P450 19A1 against testosterone at 1.5 microM (Km=0.13 uM) |
J Med Chem 29: 520-3 (1986)
BindingDB Entry DOI: 10.7270/Q28051MG |
More data for this Ligand-Target Pair | |
Aromatase
(Rattus norvegicus) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | Reactome pathway KEGG
UniProtKB/SwissProt
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| PubMed
| n/a | n/a | 6.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universität des Saarlandes
Curated by ChEMBL
| Assay Description In vitro inhibition of rat ovarian microsomal Cytochrome P450 19A1 |
J Med Chem 38: 2103-11 (1995)
BindingDB Entry DOI: 10.7270/Q2NV9H9S |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
Reactome pathway KEGG
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| DrugBank Article PubMed
| n/a | n/a | 6.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Dongguk University-Seoul
Curated by ChEMBL
| Assay Description Inhibition of HIF-1alpha in human Hep3B cells cotransfected with pGL3-HRE-luciferase plasmid after 24 hrs by dual-luciferase reporter assay |
Eur J Med Chem 90: 379-93 (2015)
Article DOI: 10.1016/j.ejmech.2014.11.047 BindingDB Entry DOI: 10.7270/Q2GF0W5F |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
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| DrugBank PubMed
| n/a | n/a | 6.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois at Chicago
Curated by ChEMBL
| Assay Description Inhibition of aromatase from human placental microsomes |
J Nat Prod 64: 1286-93 (2001)
BindingDB Entry DOI: 10.7270/Q2RB74C4 |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
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| DrugBank Article PubMed
| n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Health Sciences University of Hokkaido
Curated by ChEMBL
| Assay Description Inhibition of purified HIV-2 reverse transcriptase |
Bioorg Med Chem Lett 27: 2645-2649 (2017)
Article DOI: 10.1016/j.bmcl.2017.01.062 BindingDB Entry DOI: 10.7270/Q2CF9SH5 |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
Reactome pathway KEGG
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| DrugBank PubMed
| n/a | n/a | 8.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity against human placental cytochrome P450 19A1 |
J Med Chem 30: 1550-4 (1987)
BindingDB Entry DOI: 10.7270/Q2GM869Q |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
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| DrugBank PubMed
| n/a | n/a | 8.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Cytochrome P450 19A1 against Androstenedione at 0.25 uM (Km=55 nM) |
J Med Chem 29: 520-3 (1986)
BindingDB Entry DOI: 10.7270/Q28051MG |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
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| DrugBank Article PubMed
| n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Health Sciences University of Hokkaido
Curated by ChEMBL
| Assay Description Inhibition of CYP19 in human placental microsome using [1beta-3H]-androstenedione as substrate after 15 mins in presence of NADPH by liquid scintilla... |
Bioorg Med Chem Lett 27: 2645-2649 (2017)
Article DOI: 10.1016/j.bmcl.2017.01.062 BindingDB Entry DOI: 10.7270/Q2CF9SH5 |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
Reactome pathway KEGG
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Similars
| DrugBank Article PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114658 BindingDB Entry DOI: 10.7270/Q2NP28CD |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
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| DrugBank Article PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade de Coimbra
Curated by ChEMBL
| Assay Description Inhibition of human placental aromatase assessed as conversion of [1beta-3H]androstenedione to [1beta-3H]estrone after 20 mins by liquid scintillatio... |
Eur J Med Chem 44: 4121-7 (2009)
Article DOI: 10.1016/j.ejmech.2009.05.003 BindingDB Entry DOI: 10.7270/Q27D2V58 |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
Reactome pathway KEGG
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| DrugBank Article PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
State University of New York Upstate Medical University
Curated by ChEMBL
| Assay Description Inhibition of human aromatase transfected in human MCF7 cells |
J Med Chem 59: 5131-48 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01281 BindingDB Entry DOI: 10.7270/Q2TM7D2S |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
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| DrugBank PubMed
| n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
CIBA-GEIGY AG.
Curated by ChEMBL
| Assay Description In vitro inhibition of aldosterone production in rat adrenal tissue |
J Med Chem 34: 1329-34 (1991)
BindingDB Entry DOI: 10.7270/Q2QN65RW |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
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| DrugBank PubMed
| n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of human placental cytochrome P450 19A1 with androstenedione |
J Med Chem 30: 1550-4 (1987)
BindingDB Entry DOI: 10.7270/Q2GM869Q |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
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| n/a | n/a | 1.85E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bologna
Curated by ChEMBL
| Assay Description Inhibition of human placental microsome cytochrome P450 19A1 aromatase |
J Med Chem 44: 672-80 (2001)
BindingDB Entry DOI: 10.7270/Q28S4P6H |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
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| n/a | n/a | 1.85E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
UFR des Sciences Pharmaceutiques
Curated by ChEMBL
| Assay Description Inhibition of cytochrome P450 19A1 of human placental microsomes with [1beta,2beta-3H]testosterone |
Bioorg Med Chem Lett 13: 1553-5 (2003)
BindingDB Entry DOI: 10.7270/Q2GH9HB7 |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
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| DrugBank Article PubMed
| n/a | n/a | 1.85E+4 | n/a | n/a | n/a | n/a | n/a | 37 |
Cardiff University
| Assay Description The classical 3H2O assay was used to measure the effect of the inhibitor compounds on aromatase activity using human placental microsomes. |
J Enzyme Inhib Med Chem 20: 135-41 (2005)
Article DOI: 10.1080/14756360400015256 BindingDB Entry DOI: 10.7270/Q2B56H9Z |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
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| n/a | n/a | 1.85E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Cardiff University
Curated by ChEMBL
| Assay Description Inhibition of human placental aromatase, cytochrome P450 19A1 |
Bioorg Med Chem Lett 9: 2105-8 (1999)
BindingDB Entry DOI: 10.7270/Q2SQ8ZK7 |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
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| DrugBank Article PubMed
| n/a | n/a | 1.85E+4 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Universitat des Saarlandes
| Assay Description The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta,2beta-3H]testosterone during aromatization. After incubation, the ... |
J Med Chem 43: 1841-51 (2000)
Article DOI: 10.1021/jm991180u BindingDB Entry DOI: 10.7270/Q2D21VTH |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
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| n/a | n/a | 1.85E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universität des Saarlandes
Curated by ChEMBL
| Assay Description Inhibition of Human placental Cytochrome P450 19A1 |
J Med Chem 38: 2103-11 (1995)
BindingDB Entry DOI: 10.7270/Q2NV9H9S |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
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| DrugBank Article
| n/a | n/a | 2.85E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of Homo sapiens (human) aromatase assessed as 3H2O formation using [1beta,2beta-3H]testosterone as substrate by liquid scintillation count... |
Citation and Details
Article DOI: 10.1007/s00044-010-9368-4 BindingDB Entry DOI: 10.7270/Q21R6TCN |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
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| DrugBank Article
| n/a | n/a | 2.85E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of aromatase in Homo sapiens (human) placental microsome assessed as tritiated H2O release from [1-beta-3H] androstenedione substrate prei... |
Citation and Details
Article DOI: 10.1007/s00044-012-0059-1 BindingDB Entry DOI: 10.7270/Q2SB48NJ |
More data for this Ligand-Target Pair | |
Cholesterol side-chain cleavage enzyme, mitochondrial
(Bos taurus (Bovine)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB
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| n/a | n/a | 2.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universität des Saarlandes
Curated by ChEMBL
| Assay Description Inhibition of bovine adrenal desmolase |
J Med Chem 35: 2210-4 (1992)
BindingDB Entry DOI: 10.7270/Q26972HS |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
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| DrugBank Article PubMed
| n/a | n/a | 2.98E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Nantes University
Curated by ChEMBL
| Assay Description Inhibition of CYP19 |
Bioorg Med Chem Lett 16: 1134-7 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.099 BindingDB Entry DOI: 10.7270/Q2B27TV6 |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
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| DrugBank Article PubMed
| n/a | n/a | 2.98E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Université de Nantes
Curated by ChEMBL
| Assay Description Inhibition of aromatase in human placental microsomes |
Bioorg Med Chem Lett 18: 4713-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.094 BindingDB Entry DOI: 10.7270/Q2HD7VF7 |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
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| n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description Inhibition of Cytochrome P450 19A1 in human placenta |
J Med Chem 33: 2673-9 (1990)
BindingDB Entry DOI: 10.7270/Q29Z93WC |
More data for this Ligand-Target Pair | |
Cholesterol side-chain cleavage enzyme, mitochondrial
(Bos taurus (Bovine)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB
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| n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of bovine desmolase, cytochrome P450 11A1 |
J Med Chem 30: 1550-4 (1987)
BindingDB Entry DOI: 10.7270/Q2GM869Q |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
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| n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
CIBA-GEIGY Corporation
Curated by ChEMBL
| Assay Description In vitro inhibition of cytochrome P450 19A1 |
J Med Chem 34: 725-36 (1991)
BindingDB Entry DOI: 10.7270/Q2SB46BP |
More data for this Ligand-Target Pair | |
Aromatase
(Rattus norvegicus) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | Reactome pathway KEGG
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| n/a | n/a | 3.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universität des Saarlandes
Curated by ChEMBL
| Assay Description Inhibition of rat ovarian Cytochrome P450 19A |
J Med Chem 34: 2685-91 (1991)
BindingDB Entry DOI: 10.7270/Q2ST7NT9 |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
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| n/a | n/a | 3.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universität des Saarlandes
Curated by ChEMBL
| Assay Description In vitro inhibitory concentration against human placental Cytochrome P450 19A was determined using [1-beta,2beta-3H]testosterone as radioligand |
J Med Chem 34: 2685-91 (1991)
BindingDB Entry DOI: 10.7270/Q2ST7NT9 |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
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| n/a | n/a | 3.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universität des Saarlandes
Curated by ChEMBL
| Assay Description Concentration of the compound inhibiting Aromatase |
J Med Chem 35: 2210-4 (1992)
BindingDB Entry DOI: 10.7270/Q26972HS |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
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| n/a | n/a | 3.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universität des Saarlandes
Curated by ChEMBL
| Assay Description In vitro inhibitory concentration against human placental Cytochrome P450 19A was determined using [1-beta,2beta-3H]testosterone as radioligand |
J Med Chem 34: 2685-91 (1991)
BindingDB Entry DOI: 10.7270/Q2ST7NT9 |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
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| n/a | n/a | 3.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of human placental aromatase |
J Med Chem 29: 1362-9 (1986)
BindingDB Entry DOI: 10.7270/Q2DR2THB |
More data for this Ligand-Target Pair | |
Cytochrome P450 11B2, mitochondrial
(Rattus norvegicus) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | UniProtKB/SwissProt
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| n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universität des Saarlandes
Curated by ChEMBL
| Assay Description In vitro inhibition of ACTH-stimulated aldosterone biosynthesis in rat adrenal slices |
J Med Chem 38: 2103-11 (1995)
BindingDB Entry DOI: 10.7270/Q2NV9H9S |
More data for this Ligand-Target Pair | |
Steroid 17-alpha-hydroxylase/17,20 lyase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB
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| n/a | n/a | 6.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
CIBA-GEIGY AG.
Curated by ChEMBL
| Assay Description In vitro inhibition of progesterone production in hamster ovarian tissue |
J Med Chem 34: 1329-34 (1991)
BindingDB Entry DOI: 10.7270/Q2QN65RW |
More data for this Ligand-Target Pair | |
Cholesterol side-chain cleavage enzyme, mitochondrial
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank PubMed
| n/a | n/a | 8.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
CIBA-GEIGY Corporation
Curated by ChEMBL
| Assay Description In vitro inhibition of progesterone production in hamster ovarian tissue |
J Med Chem 34: 725-36 (1991)
BindingDB Entry DOI: 10.7270/Q2SB46BP |
More data for this Ligand-Target Pair | |
Cytochrome P450 11B2, mitochondrial
(Rattus norvegicus) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | UniProtKB/SwissProt
GoogleScholar AffyNet
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CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| n/a | n/a | 8.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universität des Saarlandes
Curated by ChEMBL
| Assay Description In vitro inhibition of ACTH-stimulated aldosterone biosynthesis in rat adrenal slices |
J Med Chem 38: 2103-11 (1995)
BindingDB Entry DOI: 10.7270/Q2NV9H9S |
More data for this Ligand-Target Pair | |
Cytochrome P450 11B2, mitochondrial
(Rattus norvegicus) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.10E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
CIBA-GEIGY AG.
Curated by ChEMBL
| Assay Description In vitro inhibition of aldosterone production in rat adrenal tissue |
J Med Chem 34: 1329-34 (1991)
BindingDB Entry DOI: 10.7270/Q2QN65RW |
More data for this Ligand-Target Pair | |