Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM23223 (7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 1.71E+3 | n/a | n/a | n/a | n/a | n/a |
MerLion Pharmaceuticals Pte Ltd Curated by ChEMBL | Assay Description Inhibition of interaction between GST-tagged Bcl-xl and Bak by surface plasmon resonance assay | Bioorg Med Chem Lett 18: 5771-3 (2009) Article DOI: 10.1016/j.bmcl.2008.09.071 BindingDB Entry DOI: 10.7270/Q2DF6R7B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human)) | BDBM23223 (7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 2.32E+3 | n/a | n/a | n/a | n/a | n/a |
Dalian University of Technology Curated by ChEMBL | Assay Description Binding affinity to cMcl-1 (residues 171 to 327) (unknown origin) by ITC assay | Bioorg Med Chem 21: 11-20 (2012) Article DOI: 10.1016/j.bmc.2012.11.008 BindingDB Entry DOI: 10.7270/Q25X2B7H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human)) | BDBM23223 (7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 2.65E+3 | n/a | n/a | n/a | n/a | n/a |
Dalian University of Technology Curated by ChEMBL | Assay Description Binding affinity to Mcl1 (unknown origin) expressed in Escherichia coli BL21 by ITC assay | Eur J Med Chem 60: 410-20 (2013) Article DOI: 10.1016/j.ejmech.2012.12.016 BindingDB Entry DOI: 10.7270/Q2959JVC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human)) | BDBM23223 (7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 2.65E+3 | n/a | n/a | n/a | n/a | n/a |
Dalian University of Technology Curated by ChEMBL | Assay Description Binding affinity to his-tagged Mcl-1 (unknown origin) expressed in Escherichia coli BL21 (DE3) cells by ITC analysis | Eur J Med Chem 59: 141-9 (2013) Article DOI: 10.1016/j.ejmech.2012.10.050 BindingDB Entry DOI: 10.7270/Q25B03V2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apoptosis regulator Bcl-2 (Homo sapiens (Human)) | BDBM23223 (7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 4.80E+3 | n/a | n/a | n/a | n/a | n/a |
Dalian University of Technology Curated by ChEMBL | Assay Description Binding affinity to Bcl2 (unknown origin) expressed in Escherichia coli BL21 by ITC assay | Eur J Med Chem 60: 410-20 (2013) Article DOI: 10.1016/j.ejmech.2012.12.016 BindingDB Entry DOI: 10.7270/Q2959JVC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM23223 (7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 3.38E+5 | n/a | n/a | n/a | n/a | n/a |
MerLion Pharmaceuticals Pte Ltd Curated by ChEMBL | Assay Description Inhibition of interaction between Bcl-xl and Bak by surface plasmon resonance assay | Bioorg Med Chem Lett 18: 5771-3 (2009) Article DOI: 10.1016/j.bmcl.2008.09.071 BindingDB Entry DOI: 10.7270/Q2DF6R7B | |||||||||||
More data for this Ligand-Target Pair |