Found 12 hits of kd for monomerid = 25817 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Lanosterol 14-alpha demethylase
(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...) | BDBM25817
(2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-...)Show InChI InChI=1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2 | PDB MMDB
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| PDB Article PubMed
| n/a | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a |
Swansea University
Curated by ChEMBL
| Assay Description Binding affinity to Mycobacterium tuberculosis CYP51 |
Antimicrob Agents Chemother 53: 1157-64 (2009)
Article DOI: 10.1128/AAC.01237-08 BindingDB Entry DOI: 10.7270/Q22V2GCB |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Sterol 14-alpha demethylase
(Trypanosoma cruzi) | BDBM25817
(2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-...)Show InChI InChI=1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2 | PDB MMDB
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| PDB Article PubMed
| n/a | n/a | n/a | 230 | n/a | n/a | n/a | 6.0 | n/a |
Vanderbilt University
| Assay Description Azole derivatives used as an inhibitor of TB and TC CYP51. |
Chem Biol 14: 1283-93 (2007)
Article DOI: 10.1016/j.chembiol.2007.10.011 BindingDB Entry DOI: 10.7270/Q22J69B7 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Lanosterol 14-alpha-demethylase
(Trypanosoma brucei) | BDBM25817
(2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-...)Show InChI InChI=1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2 | PDB MMDB
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| PDB Article PubMed
| n/a | n/a | n/a | 340 | n/a | n/a | n/a | 6.0 | n/a |
Vanderbilt University
| Assay Description Azole derivatives used as an inhibitor of TB and TC CYP51. |
Chem Biol 14: 1283-93 (2007)
Article DOI: 10.1016/j.chembiol.2007.10.011 BindingDB Entry DOI: 10.7270/Q22J69B7 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Lanosterol 14a-demethylase
(Neosartorya fumigata) | BDBM25817
(2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-...)Show InChI InChI=1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2 | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
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| Article PubMed
| n/a | n/a | n/a | 4.03E+3 | n/a | n/a | n/a | n/a | n/a |
Swansea University
Curated by ChEMBL
| Assay Description Binding affinity to Aspergillus fumigatus AF293 sterol 14-alpha demethylase isoenzyme B expressed in Escherichia coli |
Antimicrob Agents Chemother 54: 4225-34 (2010)
Article DOI: 10.1128/AAC.00316-10 BindingDB Entry DOI: 10.7270/Q2X34XRK |
More data for this Ligand-Target Pair | |
Mycocyclosin synthase
(Mycobacterium tuberculosis) | BDBM25817
(2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-...)Show InChI InChI=1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2 | PDB MMDB
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| MMDB PDB Article PubMed
| n/a | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a |
Swansea University
Curated by ChEMBL
| Assay Description Binding affinity to Mycobacterium tuberculosis CYP121 |
Antimicrob Agents Chemother 53: 1157-64 (2009)
Article DOI: 10.1128/AAC.01237-08 BindingDB Entry DOI: 10.7270/Q22V2GCB |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Sterol 14-alpha demethylase cyp51A
(Neosartorya fumigata (strain ATCC MYA-4609 / Af293...) | BDBM25817
(2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-...)Show InChI InChI=1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2 | KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
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| Article PubMed
| n/a | n/a | n/a | 1.19E+4 | n/a | n/a | n/a | n/a | n/a |
Swansea University
Curated by ChEMBL
| Assay Description Binding affinity to Aspergillus fumigatus AF293 sterol 14-alpha demethylase isoenzyme A expressed in Escherichia coli |
Antimicrob Agents Chemother 54: 4225-34 (2010)
Article DOI: 10.1128/AAC.00316-10 BindingDB Entry DOI: 10.7270/Q2X34XRK |
More data for this Ligand-Target Pair | |
Lanosterol 14-alpha demethylase
(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...) | BDBM25817
(2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-...)Show InChI InChI=1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2 | PDB MMDB
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| PDB Article PubMed
| n/a | n/a | n/a | 3.00E+4 | n/a | n/a | n/a | 7.5 | 37 |
University of California at San Francisco
| Assay Description The assay was developed based on the optical spectral property of P450 enzyme to elicit both type I and type II spectral changes (350 nm through 450 ... |
Antimicrob Agents Chemother 51: 3915-23 (2007)
Article DOI: 10.1128/AAC.00311-07 BindingDB Entry DOI: 10.7270/Q20V8B3R |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM25817
(2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-...)Show InChI InChI=1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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| Article PubMed
| n/a | n/a | n/a | 4.00E+4 | n/a | n/a | n/a | n/a | n/a |
Lek Pharmaceuticals d. d.
Curated by ChEMBL
| Assay Description Binding affinity to human His-tagged CYP51 expressed in Escherichia coli |
Bioorg Med Chem 16: 209-21 (2008)
Article DOI: 10.1016/j.bmc.2007.10.001 BindingDB Entry DOI: 10.7270/Q2TQ62DS |
More data for this Ligand-Target Pair | |
Steroid C26-monooxygenase
(Mycobacterium tuberculosis) | BDBM25817
(2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-...)Show InChI InChI=1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2 | PDB MMDB
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| Article PubMed
| n/a | n/a | n/a | 4.31E+4 | n/a | n/a | n/a | n/a | n/a |
Manchester Interdisciplinary Biocentre
| Assay Description Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va... |
J Biol Chem 285: 38270-82 (2010)
Article DOI: 10.1074/jbc.M110.164293 BindingDB Entry DOI: 10.7270/Q2251GR0 |
More data for this Ligand-Target Pair | |
Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM25817
(2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-...)Show InChI InChI=1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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| Article PubMed
| n/a | n/a | n/a | 7.00E+4 | n/a | n/a | n/a | n/a | n/a |
Swansea University
Curated by ChEMBL
| Assay Description Binding affinity to human CYP51 |
Antimicrob Agents Chemother 53: 1157-64 (2009)
Article DOI: 10.1128/AAC.01237-08 BindingDB Entry DOI: 10.7270/Q22V2GCB |
More data for this Ligand-Target Pair | |
Lanosterol 14-alpha demethylase
(Homo sapiens (Human)) | BDBM25817
(2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-...)Show InChI InChI=1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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| Article PubMed
| n/a | n/a | n/a | 1.20E+5 | n/a | n/a | n/a | n/a | n/a |
ACT LLC
Curated by ChEMBL
| Assay Description Binding affinity to human CYP51 |
Drug Metab Dispos 35: 493-500 (2007)
Article DOI: 10.1124/dmd.106.013888 BindingDB Entry DOI: 10.7270/Q2DF6S2H |
More data for this Ligand-Target Pair | |
Steroid C26-monooxygenase
(Mycobacterium tuberculosis) | BDBM25817
(2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-...)Show InChI InChI=1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2 | PDB MMDB
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| Article PubMed
| n/a | n/a | n/a | 8.60E+5 | n/a | n/a | n/a | n/a | n/a |
Manchester Interdisciplinary Biocentre
| Assay Description Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va... |
J Biol Chem 285: 38270-82 (2010)
Article DOI: 10.1074/jbc.M110.164293 BindingDB Entry DOI: 10.7270/Q2251GR0 |
More data for this Ligand-Target Pair | |