Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mycocyclosin synthase (Mycobacterium tuberculosis) | BDBM31773 (ECONAZOLE | Econazole nitrate | Gyno-pevaryl | Pev...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | 73 | n/a | n/a | n/a | n/a | n/a |
University of Cambridge Curated by ChEMBL | Assay Description Binding affinity to Mycobacterium tuberculosis H37Rv wild type CYP121 by titration assay | J Med Chem 59: 3272-302 (2016) Article DOI: 10.1021/acs.jmedchem.6b00007 BindingDB Entry DOI: 10.7270/Q2MS3VN4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lanosterol 14-alpha demethylase (Mycobacterium tuberculosis (strain CDC 1551 / Oshk...) | BDBM31773 (ECONAZOLE | Econazole nitrate | Gyno-pevaryl | Pev...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a |
Swansea University Curated by ChEMBL | Assay Description Binding affinity to Mycobacterium tuberculosis CYP51 | Antimicrob Agents Chemother 53: 1157-64 (2009) Article DOI: 10.1128/AAC.01237-08 BindingDB Entry DOI: 10.7270/Q22V2GCB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Steroid C26-monooxygenase (Mycobacterium tuberculosis) | BDBM31773 (ECONAZOLE | Econazole nitrate | Gyno-pevaryl | Pev...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | 330 | n/a | n/a | n/a | n/a | n/a |
University of California, San Francisco | Assay Description Binding assay using CYP130, CYP130 (G234) or CYP142. | J Biol Chem 284: 25211-9 (2009) Article DOI: 10.1074/jbc.M109.017632 BindingDB Entry DOI: 10.7270/Q2RR1WVC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 144 (Mycobacterium tuberculosis) | BDBM31773 (ECONAZOLE | Econazole nitrate | Gyno-pevaryl | Pev...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | 780 | n/a | n/a | n/a | n/a | n/a |
Manchester Interdisciplinary Biocentre | Assay Description Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va... | J Biol Chem 285: 38270-82 (2010) Article DOI: 10.1074/jbc.M110.164293 BindingDB Entry DOI: 10.7270/Q2251GR0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 130 (Mycobacterium tuberculosis) | BDBM31773 (ECONAZOLE | Econazole nitrate | Gyno-pevaryl | Pev...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | 1.93E+3 | n/a | n/a | n/a | n/a | n/a |
University of California, San Francisco | Assay Description Binding assay using CYP130, CYP130 (G234) or CYP142. | J Biol Chem 284: 25211-9 (2009) Article DOI: 10.1074/jbc.M109.017632 BindingDB Entry DOI: 10.7270/Q2RR1WVC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 130 (Mycobacterium tuberculosis) | BDBM31773 (ECONAZOLE | Econazole nitrate | Gyno-pevaryl | Pev...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a |
University of California, San Francisco | Assay Description Binding assay using CYP130, CYP130 (G234) or CYP142. | J Biol Chem 284: 25211-9 (2009) Article DOI: 10.1074/jbc.M109.017632 BindingDB Entry DOI: 10.7270/Q2RR1WVC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Steroid C26-monooxygenase (Mycobacterium tuberculosis) | BDBM31773 (ECONAZOLE | Econazole nitrate | Gyno-pevaryl | Pev...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | 4.60E+3 | n/a | n/a | n/a | n/a | n/a |
Manchester Interdisciplinary Biocentre | Assay Description Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va... | J Biol Chem 285: 38270-82 (2010) Article DOI: 10.1074/jbc.M110.164293 BindingDB Entry DOI: 10.7270/Q2251GR0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Steroid C26-monooxygenase (Mycobacterium tuberculosis) | BDBM31773 (ECONAZOLE | Econazole nitrate | Gyno-pevaryl | Pev...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | 1.17E+4 | n/a | n/a | n/a | n/a | n/a |
Manchester Interdisciplinary Biocentre | Assay Description Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va... | J Biol Chem 285: 38270-82 (2010) Article DOI: 10.1074/jbc.M110.164293 BindingDB Entry DOI: 10.7270/Q2251GR0 | |||||||||||
More data for this Ligand-Target Pair |