Found 4 hits of ki for monomerid = 21363 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Translocator protein
(Rattus norvegicus (rat)) | BDBM21363
(12-chloro-9-(2-fluorophenyl)-3-methyl-2,4,8-triaza...)Show SMILES Cc1ncc2CN=C(c3ccccc3F)c3cc(Cl)ccc3-n12 |t:6| Show InChI InChI=1S/C18H13ClFN3/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13/h2-9H,10H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
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DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Binding affinity of the compound was determined against rat benzodiazepine (BZD) receptor |
Bioorg Med Chem Lett 12: 3219-22 (2002)
BindingDB Entry DOI: 10.7270/Q2GQ6X4F |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1
(Rattus norvegicus (Rat)) | BDBM21363
(12-chloro-9-(2-fluorophenyl)-3-methyl-2,4,8-triaza...)Show SMILES Cc1ncc2CN=C(c3ccccc3F)c3cc(Cl)ccc3-n12 |t:6| Show InChI InChI=1S/C18H13ClFN3/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13/h2-9H,10H2,1H3 | PDB
UniProtKB/SwissProt
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CHEMBL
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PC cid
PC sid
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| PubMed
| 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 279: 803-12 (1996)
BindingDB Entry DOI: 10.7270/Q29P305P |
More data for this
Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM21363
(12-chloro-9-(2-fluorophenyl)-3-methyl-2,4,8-triaza...)Show SMILES Cc1ncc2CN=C(c3ccccc3F)c3cc(Cl)ccc3-n12 |t:6| Show InChI InChI=1S/C18H13ClFN3/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13/h2-9H,10H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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PDB
Article
PubMed
| 2.47E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant CYP3A4 in liver microsomes by mechanism based inhibition assay |
J Med Chem 58: 362-75 (2015)
Article DOI: 10.1021/jm501326k
BindingDB Entry DOI: 10.7270/Q2T1559D |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Solute carrier family 22 member 1
(Homo sapiens (Human)) | BDBM21363
(12-chloro-9-(2-fluorophenyl)-3-methyl-2,4,8-triaza...)Show SMILES Cc1ncc2CN=C(c3ccccc3F)c3cc(Cl)ccc3-n12 |t:6| Show InChI InChI=1S/C18H13ClFN3/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13/h2-9H,10H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
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CHEMBL
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KEGG
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PC cid
PC sid
PDB
UniChem
Patents
Similars
| PubMed
| 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of California
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake in OCT1-expressing HeLa cells |
J Pharmacol Exp Ther 286: 354-61 (1998)
BindingDB Entry DOI: 10.7270/Q28P63DW |
More data for this
Ligand-Target Pair | |
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