Found 50 hits of ki for monomerid = 26188 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Carbonic anhydrase 3
(Bos taurus (Cattle)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB
UniProtKB/SwissProt
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| 3.48E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ondokuz Mayis University
Curated by ChEMBL
| Assay Description Inhibition of bovine carbonic anhydrase 3 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analys... |
Eur J Med Chem 49: 68-73 (2012)
Article DOI: 10.1016/j.ejmech.2011.12.022 BindingDB Entry DOI: 10.7270/Q2N0170S |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 5B, mitochondrial
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | Reactome pathway KEGG
UniProtKB/SwissProt
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| 4.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human CA5B by stopped-flow CO2 hydration assay |
Bioorg Med Chem 18: 2159-64 (2010)
Article DOI: 10.1016/j.bmc.2010.01.076 BindingDB Entry DOI: 10.7270/Q2GQ6ZP1 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 5B, mitochondrial
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | Reactome pathway KEGG
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| 4.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Firenze
| Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... |
Bioorg Med Chem 16: 7424-8 (2008)
Article DOI: 10.1016/j.bmc.2008.06.013 BindingDB Entry DOI: 10.7270/Q2X065C8 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 3
(Bos taurus (Cattle)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB
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| 5.79E+3 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Ege University
| Assay Description CA activity was assayed by following the change in absorbance at 348 nm of 4-NPA to 4-nitrophenylate ion over a period of 3 min at 25°C using a spect... |
J Enzyme Inhib Med Chem 28: 412-7 (2013)
Article DOI: 10.3109/14756366.2011.651464 BindingDB Entry DOI: 10.7270/Q2W66JQ2 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 3
(Bos taurus (Cattle)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB
UniProtKB/SwissProt
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| Article PubMed
| 6.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Ondokuz Mayis University
| Assay Description Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion over a ... |
J Enzyme Inhib Med Chem 28: 283-8 (2013)
Article DOI: 10.3109/14756366.2011.643303 BindingDB Entry DOI: 10.7270/Q2QR4W1F |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 12
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| 8.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human CA12 by stopped-flow CO2 hydration assay |
Bioorg Med Chem 18: 2159-64 (2010)
Article DOI: 10.1016/j.bmc.2010.01.076 BindingDB Entry DOI: 10.7270/Q2GQ6ZP1 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 12
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| 8.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Firenze
| Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... |
Bioorg Med Chem 16: 7424-8 (2008)
Article DOI: 10.1016/j.bmc.2008.06.013 BindingDB Entry DOI: 10.7270/Q2X065C8 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 2
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| 9.90E+3 | -28.6 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Universita degli Studi di Firenze
| Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... |
Bioorg Med Chem 16: 7424-8 (2008)
Article DOI: 10.1016/j.bmc.2008.06.013 BindingDB Entry DOI: 10.7270/Q2X065C8 |
More data for this Ligand-Target Pair | 3D Structure (docked) |
Carbonic anhydrase 2
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| 9.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human CA2 by stopped-flow CO2 hydration assay |
Bioorg Med Chem 18: 2159-64 (2010)
Article DOI: 10.1016/j.bmc.2010.01.076 BindingDB Entry DOI: 10.7270/Q2GQ6ZP1 |
More data for this Ligand-Target Pair | 3D Structure (docked) |
Carbonic anhydrase 2
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 9.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ondokuz Mayis University
Curated by ChEMBL
| Assay Description Inhibition of human carbonic anhydrase 2 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysi... |
Eur J Med Chem 49: 68-73 (2012)
Article DOI: 10.1016/j.ejmech.2011.12.022 BindingDB Entry DOI: 10.7270/Q2N0170S |
More data for this Ligand-Target Pair | 3D Structure (docked) |
Carbonic anhydrase 2
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 9.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Balikesir University
Curated by ChEMBL
| Assay Description Inhibition of human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay |
Bioorg Med Chem Lett 25: 5636-41 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.021 BindingDB Entry DOI: 10.7270/Q251412B |
More data for this Ligand-Target Pair | 3D Structure (docked) |
Carbonic anhydrase 2
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 9.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AgriIbrahim£e£en University
Curated by ChEMBL
| Assay Description Inhibition of human erythrocytes CA2 using 4-nitrophenylacetate as substrate by esterase assay |
Bioorg Med Chem Lett 25: 3261-3 (2015)
Article DOI: 10.1016/j.bmcl.2015.05.073 BindingDB Entry DOI: 10.7270/Q2W37Z39 |
More data for this Ligand-Target Pair | 3D Structure (docked) |
Carbonic anhydrase 2
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 9.91E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assay |
Bioorg Med Chem Lett 18: 3593-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.04.077 BindingDB Entry DOI: 10.7270/Q2XP75TC |
More data for this Ligand-Target Pair | 3D Structure (docked) |
Carbonic anhydrase 2
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 9.92E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Agri Ibrahim Çeçen University
| Assay Description Kinetic studies were performed using the esterase activity method, with 4-nitrophenyl acetate (NPA) as substrate. |
J Enzyme Inhib Med Chem 27: 880-5 (2012)
Article DOI: 10.3109/14756366.2011.637202 BindingDB Entry DOI: 10.7270/Q2VH5MRR |
More data for this Ligand-Target Pair | 3D Structure (docked) |
Carbonic anhydrase 15
(Mus musculus) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | KEGG
UniProtKB/SwissProt
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| Article PubMed
| 1.02E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of mouse recombinant carbonic anhydrase 15 by stopped-flow CO2 hydrase assay |
Bioorg Med Chem Lett 18: 3593-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.04.077 BindingDB Entry DOI: 10.7270/Q2XP75TC |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 4
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 1.09E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ondokuz Mayis University
Curated by ChEMBL
| Assay Description Inhibition of human carbonic anhydrase 4 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysi... |
Eur J Med Chem 49: 68-73 (2012)
Article DOI: 10.1016/j.ejmech.2011.12.022 BindingDB Entry DOI: 10.7270/Q2N0170S |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 4
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 1.09E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human CA4 by stopped-flow CO2 hydration assay |
Bioorg Med Chem 18: 2159-64 (2010)
Article DOI: 10.1016/j.bmc.2010.01.076 BindingDB Entry DOI: 10.7270/Q2GQ6ZP1 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 4
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 1.09E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Firenze
| Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... |
Bioorg Med Chem 16: 7424-8 (2008)
Article DOI: 10.1016/j.bmc.2008.06.013 BindingDB Entry DOI: 10.7270/Q2X065C8 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 4
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| 1.09E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Agri Ibrahim Çeçen University
| Assay Description Kinetic studies were performed using the esterase activity method, with 4-nitrophenyl acetate (NPA) as substrate. |
J Enzyme Inhib Med Chem 27: 880-5 (2012)
Article DOI: 10.3109/14756366.2011.637202 BindingDB Entry DOI: 10.7270/Q2VH5MRR |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 2
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 1.14E+4 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Ondokuz Mayis University
| Assay Description Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion over a ... |
J Enzyme Inhib Med Chem 28: 283-8 (2013)
Article DOI: 10.3109/14756366.2011.643303 BindingDB Entry DOI: 10.7270/Q2QR4W1F |
More data for this Ligand-Target Pair | 3D Structure (docked) |
Carbonic anhydrase 4
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| 1.19E+4 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Ondokuz Mayis University
| Assay Description Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion over a ... |
J Enzyme Inhib Med Chem 28: 283-8 (2013)
Article DOI: 10.3109/14756366.2011.643303 BindingDB Entry DOI: 10.7270/Q2QR4W1F |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 13
(Mus musculus (mouse)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| 1.22E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of mouse CA13 by stopped-flow CO2 hydration assay |
Bioorg Med Chem 18: 2159-64 (2010)
Article DOI: 10.1016/j.bmc.2010.01.076 BindingDB Entry DOI: 10.7270/Q2GQ6ZP1 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 13
(Mus musculus (mouse)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| 1.22E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Firenze
| Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... |
Bioorg Med Chem 16: 7424-8 (2008)
Article DOI: 10.1016/j.bmc.2008.06.013 BindingDB Entry DOI: 10.7270/Q2X065C8 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 3
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 1.30E+4 | -27.9 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Universita degli Studi di Firenze
| Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... |
Bioorg Med Chem 16: 7424-8 (2008)
Article DOI: 10.1016/j.bmc.2008.06.013 BindingDB Entry DOI: 10.7270/Q2X065C8 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 3
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human CA3 by stopped-flow CO2 hydration assay |
Bioorg Med Chem 18: 2159-64 (2010)
Article DOI: 10.1016/j.bmc.2010.01.076 BindingDB Entry DOI: 10.7270/Q2GQ6ZP1 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase
(Dicentrarchus labrax) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | UniProtKB/TrEMBL
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| 1.48E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gumushane University
Curated by ChEMBL
| Assay Description Inhibition of Dicentrarchus labrax CA using 4-nitrophenylacetate substrate by esterase assay |
Bioorg Med Chem Lett 21: 4259-62 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.071 BindingDB Entry DOI: 10.7270/Q2PC32Q0 |
More data for this Ligand-Target Pair | |
Prolyl 4-hydroxylase subunit alpha-1
(Gallus gallus (Chicken)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB
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| 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oulu
| Assay Description Inhibition assay using procollagen-prolin, 2-oxoglutarate 4-dioxygenase. |
J Biol Chem 261: 7819-23 (1986)
BindingDB Entry DOI: 10.7270/Q2SJ1J6Z |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 14
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB
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| 4.89E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Firenze
| Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... |
Bioorg Med Chem 16: 7424-8 (2008)
Article DOI: 10.1016/j.bmc.2008.06.013 BindingDB Entry DOI: 10.7270/Q2X065C8 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 14
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB
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| 4.89E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human CA14 by stopped-flow CO2 hydration assay |
Bioorg Med Chem 18: 2159-64 (2010)
Article DOI: 10.1016/j.bmc.2010.01.076 BindingDB Entry DOI: 10.7270/Q2GQ6ZP1 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 5A, mitochondrial
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | Reactome pathway KEGG
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| 5.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Firenze
| Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... |
Bioorg Med Chem 16: 7424-8 (2008)
Article DOI: 10.1016/j.bmc.2008.06.013 BindingDB Entry DOI: 10.7270/Q2X065C8 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 5A, mitochondrial
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | Reactome pathway KEGG
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| 5.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human CA5A by stopped-flow CO2 hydration assay |
Bioorg Med Chem 18: 2159-64 (2010)
Article DOI: 10.1016/j.bmc.2010.01.076 BindingDB Entry DOI: 10.7270/Q2GQ6ZP1 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 9
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB MMDB
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| 1.15E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human CA9 by stopped-flow CO2 hydration assay |
Bioorg Med Chem 18: 2159-64 (2010)
Article DOI: 10.1016/j.bmc.2010.01.076 BindingDB Entry DOI: 10.7270/Q2GQ6ZP1 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 9
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB MMDB
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| 1.15E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Firenze
| Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... |
Bioorg Med Chem 16: 7424-8 (2008)
Article DOI: 10.1016/j.bmc.2008.06.013 BindingDB Entry DOI: 10.7270/Q2X065C8 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 9
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB MMDB
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| 1.15E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Balikesir University
Curated by ChEMBL
| Assay Description Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay |
Bioorg Med Chem Lett 25: 5636-41 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.021 BindingDB Entry DOI: 10.7270/Q251412B |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 6
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB
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| 6.06E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human CA6 by stopped-flow CO2 hydration assay |
Bioorg Med Chem 18: 2159-64 (2010)
Article DOI: 10.1016/j.bmc.2010.01.076 BindingDB Entry DOI: 10.7270/Q2GQ6ZP1 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 6
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB
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| 6.06E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ondokuz Mayis University
Curated by ChEMBL
| Assay Description Inhibition of human carbonic anhydrase 6 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysi... |
Eur J Med Chem 49: 68-73 (2012)
Article DOI: 10.1016/j.ejmech.2011.12.022 BindingDB Entry DOI: 10.7270/Q2N0170S |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 6
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB
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| 6.06E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Firenze
| Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... |
Bioorg Med Chem 16: 7424-8 (2008)
Article DOI: 10.1016/j.bmc.2008.06.013 BindingDB Entry DOI: 10.7270/Q2X065C8 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 6
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB
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| 6.08E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Agri Ibrahim Çeçen University
| Assay Description Kinetic studies were performed using the esterase activity method, with 4-nitrophenyl acetate (NPA) as substrate. |
J Enzyme Inhib Med Chem 27: 880-5 (2012)
Article DOI: 10.3109/14756366.2011.637202 BindingDB Entry DOI: 10.7270/Q2VH5MRR |
More data for this Ligand-Target Pair | |
3-dehydroquinate synthase
(Escherichia coli (strain K12)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | KEGG
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| 6.30E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Michigan State University
Curated by ChEMBL
| Assay Description Inhibition constant for binding to Zn2+ form of 3-dehydroquinate synthase (DHQ) purified from E. coli |
Bioorg Med Chem Lett 11: 1493-6 (2001)
BindingDB Entry DOI: 10.7270/Q2S75FMH |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 7
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB MMDB
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| 7.14E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human CA7 by stopped-flow CO2 hydration assay |
Bioorg Med Chem 18: 2159-64 (2010)
Article DOI: 10.1016/j.bmc.2010.01.076 BindingDB Entry DOI: 10.7270/Q2GQ6ZP1 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 7
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB MMDB
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| 7.14E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Firenze
| Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... |
Bioorg Med Chem 16: 7424-8 (2008)
Article DOI: 10.1016/j.bmc.2008.06.013 BindingDB Entry DOI: 10.7270/Q2X065C8 |
More data for this Ligand-Target Pair | |
3-dehydroquinate synthase
(Escherichia coli (strain K12)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | KEGG
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| 8.80E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Michigan State University
Curated by ChEMBL
| Assay Description Inhibition constant for binding to Co2+ form of 3-dehydroquinate synthase (DHQ) purified from E. coli |
Bioorg Med Chem Lett 11: 1493-6 (2001)
BindingDB Entry DOI: 10.7270/Q2S75FMH |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 1
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB MMDB
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| 4.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human CA1 by stopped-flow CO2 hydration assay |
Bioorg Med Chem 18: 2159-64 (2010)
Article DOI: 10.1016/j.bmc.2010.01.076 BindingDB Entry DOI: 10.7270/Q2GQ6ZP1 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 1
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB MMDB
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| 4.00E+6 | -13.7 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Universita degli Studi di Firenze
| Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... |
Bioorg Med Chem 16: 7424-8 (2008)
Article DOI: 10.1016/j.bmc.2008.06.013 BindingDB Entry DOI: 10.7270/Q2X065C8 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 1
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB MMDB
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| 4.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Balikesir University
Curated by ChEMBL
| Assay Description Inhibition of human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay |
Bioorg Med Chem Lett 25: 5636-41 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.021 BindingDB Entry DOI: 10.7270/Q251412B |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 1
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB MMDB
NCI pathway Reactome pathway KEGG
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| 4.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ondokuz Mayis University
Curated by ChEMBL
| Assay Description Inhibition of human carbonic anhydrase 1 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysi... |
Eur J Med Chem 49: 68-73 (2012)
Article DOI: 10.1016/j.ejmech.2011.12.022 BindingDB Entry DOI: 10.7270/Q2N0170S |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 1
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB MMDB
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| 4.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AgriIbrahim£e£en University
Curated by ChEMBL
| Assay Description Inhibition of human erythrocytes CA1 using 4-nitrophenylacetate as substrate by esterase assay |
Bioorg Med Chem Lett 25: 3261-3 (2015)
Article DOI: 10.1016/j.bmcl.2015.05.073 BindingDB Entry DOI: 10.7270/Q2W37Z39 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 1
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB MMDB
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| 4.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydrase assay |
Bioorg Med Chem Lett 18: 3593-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.04.077 BindingDB Entry DOI: 10.7270/Q2XP75TC |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 1
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB MMDB
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| 4.01E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Agri Ibrahim Çeçen University
| Assay Description Kinetic studies were performed using the esterase activity method, with 4-nitrophenyl acetate (NPA) as substrate. |
J Enzyme Inhib Med Chem 27: 880-5 (2012)
Article DOI: 10.3109/14756366.2011.637202 BindingDB Entry DOI: 10.7270/Q2VH5MRR |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 1
(Homo sapiens (Human)) | BDBM26188
(α-CA inhibitor, 12 | 1,2-Dihydroxybenzene, XI...)Show InChI InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H | PDB MMDB
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| 4.01E+6 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Ondokuz Mayis University
| Assay Description Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion over a ... |
J Enzyme Inhib Med Chem 28: 283-8 (2013)
Article DOI: 10.3109/14756366.2011.643303 BindingDB Entry DOI: 10.7270/Q2QR4W1F |
More data for this Ligand-Target Pair | |