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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Carbonic anhydrase (Dicentrarchus labrax) | BDBM26189 (α-CA inhibitor, 13 | 1,3-Dihydroxybenzene, XI...) | UniProtKB/TrEMBL GoogleScholar AffyNet  | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 6.42E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gumushane University Curated by ChEMBL | Assay Description Inhibition of Dicentrarchus labrax CA using 4-nitrophenylacetate substrate by esterase assay | Bioorg Med Chem Lett 21: 4259-62 (2011) Article DOI: 10.1016/j.bmcl.2011.05.071 BindingDB Entry DOI: 10.7270/Q2PC32Q0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Carbonic anhydrase 5B, mitochondrial (Homo sapiens (Human)) | BDBM26189 (α-CA inhibitor, 13 | 1,3-Dihydroxybenzene, XI...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 7.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Firenze | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 16: 7424-8 (2008) Article DOI: 10.1016/j.bmc.2008.06.013 BindingDB Entry DOI: 10.7270/Q2X065C8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Carbonic anhydrase 12 (Homo sapiens (Human)) | BDBM26189 (α-CA inhibitor, 13 | 1,3-Dihydroxybenzene, XI...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 7.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Firenze | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 16: 7424-8 (2008) Article DOI: 10.1016/j.bmc.2008.06.013 BindingDB Entry DOI: 10.7270/Q2X065C8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Carbonic anhydrase 2 (Homo sapiens (Human)) | BDBM26189 (α-CA inhibitor, 13 | 1,3-Dihydroxybenzene, XI...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 7.70E+3 | -29.2 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Universita degli Studi di Firenze | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 16: 7424-8 (2008) Article DOI: 10.1016/j.bmc.2008.06.013 BindingDB Entry DOI: 10.7270/Q2X065C8 | |||||||||||
| More data for this Ligand-Target Pair |  3D Structure (docked) | ||||||||||||
| Carbonic anhydrase 2 (Homo sapiens (Human)) | BDBM26189 (α-CA inhibitor, 13 | 1,3-Dihydroxybenzene, XI...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 7.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AgriIbrahim£e£en University Curated by ChEMBL | Assay Description Inhibition of human erythrocytes CA2 using 4-nitrophenylacetate as substrate by esterase assay | Bioorg Med Chem Lett 25: 3261-3 (2015) Article DOI: 10.1016/j.bmcl.2015.05.073 BindingDB Entry DOI: 10.7270/Q2W37Z39 | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
| Carbonic anhydrase 2 (Homo sapiens (Human)) | BDBM26189 (α-CA inhibitor, 13 | 1,3-Dihydroxybenzene, XI...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 7.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze Curated by ChEMBL | Assay Description Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assay | Bioorg Med Chem Lett 18: 3593-6 (2008) Article DOI: 10.1016/j.bmcl.2008.04.077 BindingDB Entry DOI: 10.7270/Q2XP75TC | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
| Carbonic anhydrase 5A, mitochondrial (Homo sapiens (Human)) | BDBM26189 (α-CA inhibitor, 13 | 1,3-Dihydroxybenzene, XI...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 8.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Firenze | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 16: 7424-8 (2008) Article DOI: 10.1016/j.bmc.2008.06.013 BindingDB Entry DOI: 10.7270/Q2X065C8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Carbonic anhydrase 2 (Homo sapiens (Human)) | BDBM26189 (α-CA inhibitor, 13 | 1,3-Dihydroxybenzene, XI...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 9.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Ondokuz Mayis University | Assay Description Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion over a ... | J Enzyme Inhib Med Chem 28: 283-8 (2013) Article DOI: 10.3109/14756366.2011.643303 BindingDB Entry DOI: 10.7270/Q2QR4W1F | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
| Carbonic anhydrase 14 (Homo sapiens (Human)) | BDBM26189 (α-CA inhibitor, 13 | 1,3-Dihydroxybenzene, XI...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 1.07E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Firenze | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 16: 7424-8 (2008) Article DOI: 10.1016/j.bmc.2008.06.013 BindingDB Entry DOI: 10.7270/Q2X065C8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Carbonic anhydrase 13 (Mus musculus (mouse)) | BDBM26189 (α-CA inhibitor, 13 | 1,3-Dihydroxybenzene, XI...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 6.26E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Firenze | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 16: 7424-8 (2008) Article DOI: 10.1016/j.bmc.2008.06.013 BindingDB Entry DOI: 10.7270/Q2X065C8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Carbonic anhydrase 9 (Homo sapiens (Human)) | BDBM26189 (α-CA inhibitor, 13 | 1,3-Dihydroxybenzene, XI...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 6.97E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Firenze | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 16: 7424-8 (2008) Article DOI: 10.1016/j.bmc.2008.06.013 BindingDB Entry DOI: 10.7270/Q2X065C8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Carbonic anhydrase 3 (Bos taurus (Cattle)) | BDBM26189 (α-CA inhibitor, 13 | 1,3-Dihydroxybenzene, XI...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 1.96E+5 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Ege University | Assay Description CA activity was assayed by following the change in absorbance at 348 nm of 4-NPA to 4-nitrophenylate ion over a period of 3 min at 25°C using a spect... | J Enzyme Inhib Med Chem 28: 412-7 (2013) Article DOI: 10.3109/14756366.2011.651464 BindingDB Entry DOI: 10.7270/Q2W66JQ2 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Carbonic anhydrase 3 (Bos taurus (Cattle)) | BDBM26189 (α-CA inhibitor, 13 | 1,3-Dihydroxybenzene, XI...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 2.19E+5 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Ondokuz Mayis University | Assay Description Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion over a ... | J Enzyme Inhib Med Chem 28: 283-8 (2013) Article DOI: 10.3109/14756366.2011.643303 BindingDB Entry DOI: 10.7270/Q2QR4W1F | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Carbonic anhydrase 15 (Mus musculus) | BDBM26189 (α-CA inhibitor, 13 | 1,3-Dihydroxybenzene, XI...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 3.85E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze Curated by ChEMBL | Assay Description Inhibition of mouse recombinant carbonic anhydrase 15 by stopped-flow CO2 hydrase assay | Bioorg Med Chem Lett 18: 3593-6 (2008) Article DOI: 10.1016/j.bmcl.2008.04.077 BindingDB Entry DOI: 10.7270/Q2XP75TC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Carbonic anhydrase 6 (Homo sapiens (Human)) | BDBM26189 (α-CA inhibitor, 13 | 1,3-Dihydroxybenzene, XI...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 5.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Firenze | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 16: 7424-8 (2008) Article DOI: 10.1016/j.bmc.2008.06.013 BindingDB Entry DOI: 10.7270/Q2X065C8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Carbonic anhydrase 4 (Homo sapiens (Human)) | BDBM26189 (α-CA inhibitor, 13 | 1,3-Dihydroxybenzene, XI...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 5.70E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Firenze | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 16: 7424-8 (2008) Article DOI: 10.1016/j.bmc.2008.06.013 BindingDB Entry DOI: 10.7270/Q2X065C8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Carbonic anhydrase 3 (Homo sapiens (Human)) | BDBM26189 (α-CA inhibitor, 13 | 1,3-Dihydroxybenzene, XI...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 6.05E+5 | -18.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Universita degli Studi di Firenze | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 16: 7424-8 (2008) Article DOI: 10.1016/j.bmc.2008.06.013 BindingDB Entry DOI: 10.7270/Q2X065C8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Carbonic anhydrase 4 (Homo sapiens (Human)) | BDBM26189 (α-CA inhibitor, 13 | 1,3-Dihydroxybenzene, XI...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 6.34E+5 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Ondokuz Mayis University | Assay Description Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion over a ... | J Enzyme Inhib Med Chem 28: 283-8 (2013) Article DOI: 10.3109/14756366.2011.643303 BindingDB Entry DOI: 10.7270/Q2QR4W1F | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Carbonic anhydrase 7 (Homo sapiens (Human)) | BDBM26189 (α-CA inhibitor, 13 | 1,3-Dihydroxybenzene, XI...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 6.44E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Firenze | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 16: 7424-8 (2008) Article DOI: 10.1016/j.bmc.2008.06.013 BindingDB Entry DOI: 10.7270/Q2X065C8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Carbonic anhydrase 1 (Homo sapiens (Human)) | BDBM26189 (α-CA inhibitor, 13 | 1,3-Dihydroxybenzene, XI...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 7.95E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AgriIbrahim£e£en University Curated by ChEMBL | Assay Description Inhibition of human erythrocytes CA1 using 4-nitrophenylacetate as substrate by esterase assay | Bioorg Med Chem Lett 25: 3261-3 (2015) Article DOI: 10.1016/j.bmcl.2015.05.073 BindingDB Entry DOI: 10.7270/Q2W37Z39 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Carbonic anhydrase 1 (Homo sapiens (Human)) | BDBM26189 (α-CA inhibitor, 13 | 1,3-Dihydroxybenzene, XI...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 7.95E+5 | -17.7 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Universita degli Studi di Firenze | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 16: 7424-8 (2008) Article DOI: 10.1016/j.bmc.2008.06.013 BindingDB Entry DOI: 10.7270/Q2X065C8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Carbonic anhydrase 1 (Homo sapiens (Human)) | BDBM26189 (α-CA inhibitor, 13 | 1,3-Dihydroxybenzene, XI...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 7.95E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze Curated by ChEMBL | Assay Description Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydrase assay | Bioorg Med Chem Lett 18: 3593-6 (2008) Article DOI: 10.1016/j.bmcl.2008.04.077 BindingDB Entry DOI: 10.7270/Q2XP75TC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Carbonic anhydrase 1 (Homo sapiens (Human)) | BDBM26189 (α-CA inhibitor, 13 | 1,3-Dihydroxybenzene, XI...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 8.28E+5 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Ondokuz Mayis University | Assay Description Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion over a ... | J Enzyme Inhib Med Chem 28: 283-8 (2013) Article DOI: 10.3109/14756366.2011.643303 BindingDB Entry DOI: 10.7270/Q2QR4W1F | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Prolyl 4-hydroxylase subunit alpha-1 (Gallus gallus (Chicken)) | BDBM26189 (α-CA inhibitor, 13 | 1,3-Dihydroxybenzene, XI...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | 1.02E+7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oulu | Assay Description Inhibition assay using procollagen-prolin, 2-oxoglutarate 4-dioxygenase. | J Biol Chem 261: 7819-23 (1986) BindingDB Entry DOI: 10.7270/Q2SJ1J6Z | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
