Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein kinase C delta type (Mus musculus) | BDBM50107112 ((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Cancer Institute-Frederick Curated by ChEMBL | Assay Description Displacement of [3H]PDBu from mouse wild type C1b domain of PKCdelta expressed in Escherichia coli | J Med Chem 50: 3465-81 (2007) Article DOI: 10.1021/jm0702579 BindingDB Entry DOI: 10.7270/Q2RF5TQ5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein kinase C delta type (Homo sapiens (Human)) | BDBM50107112 ((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.16 | -49.8 | n/a | n/a | n/a | n/a | n/a | 7.4 | 18 |
National Institutes of Health | Assay Description [3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay. | J Biol Chem 283: 10543-9 (2008) Article DOI: 10.1074/jbc.M707463200 BindingDB Entry DOI: 10.7270/Q2CF9NQ6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein kinase C delta type (Homo sapiens (Human)) | BDBM50107112 ((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Cancer Institute-Frederick Curated by ChEMBL | Assay Description Inhibition of [3H]-PDBu binding to C1b domain of protein kinase C delta | J Med Chem 48: 5738-48 (2005) Article DOI: 10.1021/jm050352m BindingDB Entry DOI: 10.7270/Q27M07G5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein kinase C delta type (Homo sapiens (Human)) | BDBM50107112 ((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Cancer Institute-Frederick Curated by ChEMBL | Assay Description Binding affinity for isolated C1b domain of protein kinase C-delta | J Med Chem 47: 4858-64 (2004) Article DOI: 10.1021/jm049723+ BindingDB Entry DOI: 10.7270/Q25D8SMX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein kinase C delta type (Mus musculus) | BDBM50107112 ((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Cancer Institute-Frederick Curated by ChEMBL | Assay Description Binding affinity to mouse wildtype PKCdelta C1a expressed in Escherichia coli | J Med Chem 50: 3465-81 (2007) Article DOI: 10.1021/jm0702579 BindingDB Entry DOI: 10.7270/Q2RF5TQ5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein kinase C alpha type (Homo sapiens (Human)) | BDBM50107112 ((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Cancer Institute at Frederick Curated by ChEMBL | Assay Description Binding affinity for Protein kinase C alpha C1a or C1b domain | J Med Chem 46: 2790-3 (2003) Article DOI: 10.1021/jm030082c BindingDB Entry DOI: 10.7270/Q2VH5PJW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein kinase C alpha type (Homo sapiens (Human)) | BDBM50107112 ((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
National Cancer Institute-Frederick Curated by ChEMBL | Assay Description Inhibition of [3H]PDBu binding to recombinant protein kinase C alpha was determined at pH 7.4, 37 degree C for 5 min | J Med Chem 48: 5738-48 (2005) Article DOI: 10.1021/jm050352m BindingDB Entry DOI: 10.7270/Q27M07G5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein kinase C alpha type (Homo sapiens (Human)) | BDBM50107112 ((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Research Institute of Pharmaceutical Sciences Curated by ChEMBL | Assay Description Displacement of [20-3H]PDBu from recombinant PKC alpha in presence of phosphatidylserine | J Med Chem 49: 2028-36 (2006) Article DOI: 10.1021/jm0509391 BindingDB Entry DOI: 10.7270/Q27D2TQ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein kinase C alpha type (MOUSE) | BDBM50107112 ((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Cancer Institute-Frederick Curated by ChEMBL | Assay Description Displacement of [3H]PDBu from mouse recombinant PKCalpha expressed in Escherichia coli | J Med Chem 50: 3465-81 (2007) Article DOI: 10.1021/jm0702579 BindingDB Entry DOI: 10.7270/Q2RF5TQ5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein kinase C alpha type (Homo sapiens (Human)) | BDBM50107112 ((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University Curated by ChEMBL | Assay Description Displacement of [20-3H]-PDBU ligand from recombinant protein kinase C (baculovirus) | J Med Chem 44: 4309-12 (2001) BindingDB Entry DOI: 10.7270/Q25D8R5P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein kinase C delta type (Mus musculus) | BDBM50107112 ((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 44.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Cancer Institute-Frederick Curated by ChEMBL | Assay Description Displacement of [3H]PDBu from mouse PKCdelta C1b Q27E mutant expressed in Escherichia coli | J Med Chem 50: 3465-81 (2007) Article DOI: 10.1021/jm0702579 BindingDB Entry DOI: 10.7270/Q2RF5TQ5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein kinase C alpha type (Homo sapiens (Human)) | BDBM50107112 ((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 402 | -35.6 | n/a | n/a | n/a | n/a | n/a | 7.4 | 18 |
National Institutes of Health | Assay Description [3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay. | J Biol Chem 283: 10543-9 (2008) Article DOI: 10.1074/jbc.M707463200 BindingDB Entry DOI: 10.7270/Q2CF9NQ6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein kinase C delta type (Mus musculus) | BDBM50107112 ((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 476 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Cancer Institute-Frederick Curated by ChEMBL | Assay Description Binding affinity to mouse PKC delta C1a Q27E mutant expressed in Escherichia coli | J Med Chem 50: 3465-81 (2007) Article DOI: 10.1021/jm0702579 BindingDB Entry DOI: 10.7270/Q2RF5TQ5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase MRCK alpha (Homo sapiens (Human)) | BDBM50107112 ((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.03E+3 | -33.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 18 |
National Institutes of Health | Assay Description [3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay. | J Biol Chem 283: 10543-9 (2008) Article DOI: 10.1074/jbc.M707463200 BindingDB Entry DOI: 10.7270/Q2CF9NQ6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase MRCK beta (Homo sapiens (Human)) | BDBM50107112 ((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.07E+3 | -33.3 | n/a | n/a | n/a | n/a | n/a | 7.4 | 18 |
National Institutes of Health | Assay Description [3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay. | J Biol Chem 283: 10543-9 (2008) Article DOI: 10.1074/jbc.M707463200 BindingDB Entry DOI: 10.7270/Q2CF9NQ6 | |||||||||||
More data for this Ligand-Target Pair |