Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Translocator protein (Rattus norvegicus (rat)) | BDBM50122293 (CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | 0.0430 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Radiological Sciences Curated by ChEMBL | Assay Description In vitro binding affinity for PBR (peripheral benzodiazepine receptor) in rat brain | Bioorg Med Chem Lett 13: 201-4 (2002) BindingDB Entry DOI: 10.7270/Q2PZ585X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50122293 (CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 0.0726 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Binding affinity to PBR in Sprague-Dawley rat mitochondrial tissue | J Med Chem 51: 17-30 (2008) Article DOI: 10.1021/jm0707370 BindingDB Entry DOI: 10.7270/Q2N58M32 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50122293 (CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 0.0726 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from rat PBR receptor | J Med Chem 52: 688-99 (2009) Article DOI: 10.1021/jm8011855 BindingDB Entry DOI: 10.7270/Q2HX1CJP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50122293 (CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Radiological Sciences Curated by ChEMBL | Assay Description Displacement of [11C](R)-PK1119 from Sprague-Dawley rat brain PBR | J Med Chem 49: 2735-42 (2006) Article DOI: 10.1021/jm060006k BindingDB Entry DOI: 10.7270/Q20K29CW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50122293 (CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Radiological Sciences Curated by ChEMBL | Assay Description Displacement of [11C]DAA1106 from Sprague-Dawley rat brain PBR | J Med Chem 49: 2735-42 (2006) Article DOI: 10.1021/jm060006k BindingDB Entry DOI: 10.7270/Q20K29CW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50122293 (CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Radiological Sciences Curated by ChEMBL | Assay Description In vitro inhibition of [11C]2 binding to Peripheral benzodiazepine receptor (PBR) in rat brain | J Med Chem 47: 2228-35 (2004) Article DOI: 10.1021/jm0304919 BindingDB Entry DOI: 10.7270/Q20G3KXQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Homo sapiens (Human)) | BDBM50122293 (CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | 0.188 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Radiological Sciences Curated by ChEMBL | Assay Description In vitro binding affinity for PBR (peripheral benzodiazepine receptor) in monkey brain | Bioorg Med Chem Lett 13: 201-4 (2002) BindingDB Entry DOI: 10.7270/Q2PZ585X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Homo sapiens (Human)) | BDBM50122293 (CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Stanford University School of Medicine Curated by ChEMBL | Assay Description Inhibition of human TSPO | Eur J Med Chem 93: 392-400 (2015) Article DOI: 10.1016/j.ejmech.2015.02.004 BindingDB Entry DOI: 10.7270/Q2G73GF4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Homo sapiens (Human)) | BDBM50122293 (CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 0.242 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from human PBR receptor | J Med Chem 52: 688-99 (2009) Article DOI: 10.1021/jm8011855 BindingDB Entry DOI: 10.7270/Q2HX1CJP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Homo sapiens (Human)) | BDBM50122293 (CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 0.242 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Binding affinity to PBR in human mitochondrial tissue | J Med Chem 51: 17-30 (2008) Article DOI: 10.1021/jm0707370 BindingDB Entry DOI: 10.7270/Q2N58M32 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50122293 (CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 0.430 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GE Healthcare Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from TSPO in Wistar rat heart incubated for 15 mins | Bioorg Med Chem Lett 22: 5795-800 (2012) Article DOI: 10.1016/j.bmcl.2012.07.093 BindingDB Entry DOI: 10.7270/Q29K4CBT | |||||||||||
More data for this Ligand-Target Pair |