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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Procathepsin L (Homo sapiens (Human)) | BDBM50157741 (CHEMBL374508 | E-64 | E64) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet  | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina , Viale Annunziata, 98168 Messina, Italy. Curated by ChEMBL | Assay Description Inhibition of human cathepsin L using Cbz-Phe-Arg-AMC as substrate after 10 mins by fluorescence assay | J Med Chem 60: 6911-6923 (2017) Article DOI: 10.1021/acs.jmedchem.7b00405 BindingDB Entry DOI: 10.7270/Q2FJ2K73 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cysteine protease (Trypanosoma brucei rhodesiense) | BDBM50157741 (CHEMBL374508 | E-64 | E64) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 35 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina , Viale Annunziata, 98168 Messina, Italy. Curated by ChEMBL | Assay Description Inhibition of recombinant Trypanosoma brucei rhodesiense rhodesain expressed in Pichia pastoris using Cbz-Phe-Arg-AMC as substrate after 30 min by fl... | J Med Chem 60: 6911-6923 (2017) Article DOI: 10.1021/acs.jmedchem.7b00405 BindingDB Entry DOI: 10.7270/Q2FJ2K73 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Falcipain 2 (Plasmodium falciparum) | BDBM50157741 (CHEMBL374508 | E-64 | E64) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 290 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Messina Curated by ChEMBL | Assay Description Inhibition of Plasmodium falciparum recombinant falcipain-2 | J Med Chem 51: 988-96 (2008) Article DOI: 10.1021/jm701141u BindingDB Entry DOI: 10.7270/Q2SX6F2M | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Falcipain 2 (Plasmodium falciparum) | BDBM50157741 (CHEMBL374508 | E-64 | E64) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 290 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Messina Curated by ChEMBL | Assay Description Inhibition of Plasmodium falciparum recombinant falcipain-2 after 10 min | Bioorg Med Chem 18: 4928-38 (2010) Article DOI: 10.1016/j.bmc.2010.06.010 BindingDB Entry DOI: 10.7270/Q2NK3G1R | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Calpain-1 catalytic subunit (Sus scrofa (pig)) | BDBM50157741 (CHEMBL374508 | E-64 | E64) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 3.96E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois College of Pharmacy Curated by ChEMBL | Assay Description Inhibition of pig full length Cal1 after using SucLLVYAMC as substrate by FRET assay | J Med Chem 56: 6054-68 (2013) Article DOI: 10.1021/jm4006719 BindingDB Entry DOI: 10.7270/Q2VT1TG7 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Papain (Carica papaya) | BDBM50157741 (CHEMBL374508 | E-64 | E64) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 5.08E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois College of Pharmacy Curated by ChEMBL | Assay Description Inhibition of papain after using SucLLVYAMC as substrate by FRET assay | J Med Chem 56: 6054-68 (2013) Article DOI: 10.1021/jm4006719 BindingDB Entry DOI: 10.7270/Q2VT1TG7 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Falcipain 2 (Plasmodium falciparum) | BDBM50157741 (CHEMBL374508 | E-64 | E64) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 4.03E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Messina Curated by ChEMBL | Assay Description Inhibition of Plasmodium falciparum Falcipain-2 after 10 to 15 mins | Eur J Med Chem 45: 3228-33 (2010) Article DOI: 10.1016/j.ejmech.2010.04.003 BindingDB Entry DOI: 10.7270/Q2SN094T | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
