Found 8 hits of ki for monomerid = 50164644 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50164644
(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | 2',3...)Show SMILES Nc1ncnc2n(cnc12)[C@H]1CC[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 |r| Show InChI InChI=1S/C10H16N5O11P3/c11-9-8-10(13-4-12-9)15(5-14-8)7-2-1-6(24-7)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h4-7H,1-3H2,(H,19,20)(H,21,22)(H2,11,12,13)(H2,16,17,18)/t6-,7+/m0/s1 | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
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MCE
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MMDB
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| PDB
Article
PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biota, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory constant against HIV-1 reverse transcriptase |
J Med Chem 48: 2695-700 (2005)
Article DOI: 10.1021/jm040101y
BindingDB Entry DOI: 10.7270/Q2G73FG5 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Reverse transcriptase protein
(Human immunodeficiency virus 1) | BDBM50164644
(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | 2',3...)Show SMILES Nc1ncnc2n(cnc12)[C@H]1CC[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 |r| Show InChI InChI=1S/C10H16N5O11P3/c11-9-8-10(13-4-12-9)15(5-14-8)7-2-1-6(24-7)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h4-7H,1-3H2,(H,19,20)(H,21,22)(H2,11,12,13)(H2,16,17,18)/t6-,7+/m0/s1 | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
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CHEMBL
MCE
KEGG
MMDB
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| Article
PubMed
| 50 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
McGill University
Curated by ChEMBL
| Assay Description
Inhibition of HIV1 reverse transcriptase M41L/D67N/L210W/T215Y mutant by steady state nucleotide incorporation assay |
Antimicrob Agents Chemother 51: 2911-9 (2007)
Article DOI: 10.1128/aac.00314-07
BindingDB Entry DOI: 10.7270/Q2CV4MJS |
More data for this
Ligand-Target Pair | |
P2X purinoceptor 2
(Homo sapiens (Human)) | BDBM50164644
(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | 2',3...)Show SMILES Nc1ncnc2n(cnc12)[C@H]1CC[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 |r| Show InChI InChI=1S/C10H16N5O11P3/c11-9-8-10(13-4-12-9)15(5-14-8)7-2-1-6(24-7)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h4-7H,1-3H2,(H,19,20)(H,21,22)(H2,11,12,13)(H2,16,17,18)/t6-,7+/m0/s1 | UniProtKB/SwissProt
antibodypedia
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| Article
PubMed
| 75.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 310: 407-16 (2004)
Article DOI: 10.1124/jpet.103.064907
BindingDB Entry DOI: 10.7270/Q2SQ8XZR |
More data for this
Ligand-Target Pair | |
Reverse transcriptase
(Human immunodeficiency virus 1) | BDBM50164644
(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | 2',3...)Show SMILES Nc1ncnc2n(cnc12)[C@H]1CC[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 |r| Show InChI InChI=1S/C10H16N5O11P3/c11-9-8-10(13-4-12-9)15(5-14-8)7-2-1-6(24-7)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h4-7H,1-3H2,(H,19,20)(H,21,22)(H2,11,12,13)(H2,16,17,18)/t6-,7+/m0/s1 | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
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CHEMBL
MCE
KEGG
MMDB
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PC sid
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| Article
PubMed
| 90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
McGill University
Curated by ChEMBL
| Assay Description
Inhibition of HIV1 reverse transcriptase by steady state nucleotide incorporation assay |
Antimicrob Agents Chemother 51: 2911-9 (2007)
Article DOI: 10.1128/aac.00314-07
BindingDB Entry DOI: 10.7270/Q2CV4MJS |
More data for this
Ligand-Target Pair | |
P2X purinoceptor 3
(Homo sapiens (Human)) | BDBM50164644
(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | 2',3...)Show SMILES Nc1ncnc2n(cnc12)[C@H]1CC[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 |r| Show InChI InChI=1S/C10H16N5O11P3/c11-9-8-10(13-4-12-9)15(5-14-8)7-2-1-6(24-7)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h4-7H,1-3H2,(H,19,20)(H,21,22)(H2,11,12,13)(H2,16,17,18)/t6-,7+/m0/s1 | PDB
KEGG
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antibodypedia
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| Article
PubMed
| 406 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 310: 407-16 (2004)
Article DOI: 10.1124/jpet.103.064907
BindingDB Entry DOI: 10.7270/Q2SQ8XZR |
More data for this
Ligand-Target Pair | |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50164644
(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | 2',3...)Show SMILES Nc1ncnc2n(cnc12)[C@H]1CC[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 |r| Show InChI InChI=1S/C10H16N5O11P3/c11-9-8-10(13-4-12-9)15(5-14-8)7-2-1-6(24-7)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h4-7H,1-3H2,(H,19,20)(H,21,22)(H2,11,12,13)(H2,16,17,18)/t6-,7+/m0/s1 | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
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| Purchase
CHEMBL
MCE
KEGG
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PC sid
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| PDB
Article
PubMed
| 500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wayne State University School of Medicine
Curated by ChEMBL
| Assay Description
Inhibitory activity against HIV-1 reverse transcriptase (RT M184V) |
J Med Chem 46: 4799-802 (2003)
Article DOI: 10.1021/jm030048y
BindingDB Entry DOI: 10.7270/Q2D50NQB |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50164644
(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | 2',3...)Show SMILES Nc1ncnc2n(cnc12)[C@H]1CC[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 |r| Show InChI InChI=1S/C10H16N5O11P3/c11-9-8-10(13-4-12-9)15(5-14-8)7-2-1-6(24-7)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h4-7H,1-3H2,(H,19,20)(H,21,22)(H2,11,12,13)(H2,16,17,18)/t6-,7+/m0/s1 | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
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CHEMBL
MCE
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| PDB
Article
PubMed
| 510 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wayne State University School of Medicine
Curated by ChEMBL
| Assay Description
Inhibitory activity against HIV-1 Reverse transcriptase wild-type (RT wt) |
J Med Chem 46: 4799-802 (2003)
Article DOI: 10.1021/jm030048y
BindingDB Entry DOI: 10.7270/Q2D50NQB |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1) | BDBM50164644
(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | 2',3...)Show SMILES Nc1ncnc2n(cnc12)[C@H]1CC[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 |r| Show InChI InChI=1S/C10H16N5O11P3/c11-9-8-10(13-4-12-9)15(5-14-8)7-2-1-6(24-7)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h4-7H,1-3H2,(H,19,20)(H,21,22)(H2,11,12,13)(H2,16,17,18)/t6-,7+/m0/s1 | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
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CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
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| PDB
Article
PubMed
| 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wayne State University School of Medicine
Curated by ChEMBL
| Assay Description
Inhibitory activity against HIV-1 reverse transcriptase (RT M184I) |
J Med Chem 46: 4799-802 (2003)
Article DOI: 10.1021/jm030048y
BindingDB Entry DOI: 10.7270/Q2D50NQB |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
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