Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aurora kinase A (Homo sapiens (Human)) | BDBM50277545 (4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 0.136 | -57.3 | 34.2 | n/a | n/a | n/a | n/a | n/a | 30 |
University of Tartu, Ravila 14A, 50411 Tartu (Estonia) | Assay Description Threefold dilution series of inhibitors in assay buffer were prepared in wells of a microtiter plate (final concentration stating from 2uM), and TAMR... | Chembiochem 15: 443-50 (2014) Article DOI: 10.1002/cbic.201300613 BindingDB Entry DOI: 10.7270/Q2028Q58 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Aurora kinase A (Mus musculus (mouse)) | BDBM50277545 (4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States. Curated by ChEMBL | Assay Description Competitive inhibition of recombinant mouse aurora kinase A expressed in insect Sf9 cells in presence of ATP | ACS Med Chem Lett 6: 630-4 (2015) Article DOI: 10.1021/ml500409n BindingDB Entry DOI: 10.7270/Q2WS8W1V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aurora kinase A/Targeting protein for Xklp2 [1-43] (Homo sapiens (Human)) | BDBM50277545 (4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 1.86 | -50.7 | 1.78E+3 | n/a | n/a | n/a | n/a | n/a | 30 |
University of Tartu, Ravila 14A, 50411 Tartu (Estonia) | Assay Description Threefold dilution series of inhibitors in assay buffer were prepared in wells of a microtiter plate (final concentration stating from 2uM), and TAMR... | Chembiochem 15: 443-50 (2014) Article DOI: 10.1002/cbic.201300613 BindingDB Entry DOI: 10.7270/Q2028Q58 | |||||||||||
More data for this Ligand-Target Pair |