Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cathepsin B (Capra hircus (Goat)) | BDBM50286441 ((S)-2-((S)-2-Acetylamino-4-(S)-methyl-pentanoylami...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kurukshetra University Curated by ChEMBL | Assay Description Competitive inhibition of goat brain cathepsin B | Eur J Med Chem 77: 231-42 (2014) Article DOI: 10.1016/j.ejmech.2014.03.007 BindingDB Entry DOI: 10.7270/Q2319XDV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin B (Homo sapiens (Human)) | BDBM50286441 ((S)-2-((S)-2-Acetylamino-4-(S)-methyl-pentanoylami...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kurukshetra University Curated by ChEMBL | Assay Description Inhibition of human liver cathepsin B | Eur J Med Chem 77: 231-42 (2014) Article DOI: 10.1016/j.ejmech.2014.03.007 BindingDB Entry DOI: 10.7270/Q2319XDV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin B (Homo sapiens (Human)) | BDBM50286441 ((S)-2-((S)-2-Acetylamino-4-(S)-methyl-pentanoylami...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kurukshetra University Curated by ChEMBL | Assay Description Inhibition of human liver cathepsin B | Bioorg Med Chem 22: 4233-45 (2014) Article DOI: 10.1016/j.bmc.2014.05.037 BindingDB Entry DOI: 10.7270/Q25Q4XQH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine protease 1 (Homo sapiens (Human)) | BDBM50286441 ((S)-2-((S)-2-Acetylamino-4-(S)-methyl-pentanoylami...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 8 | n/a | n/a | n/a | n/a | n/a | n/a | 7.5 | n/a |
Medical University of Bialystok | Assay Description Buffer and 0.1 mL of enzyme solution was added to 0.2 mL of examined compounddissolved in 0.15 M NaCl (as control 0.15 M NaCl). The buffer and the en... | J Enzyme Inhib Med Chem 28: 639-43 (2013) Article DOI: 10.3109/14756366.2011.651463 BindingDB Entry DOI: 10.7270/Q2HQ3XTK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen (Homo sapiens (Human)) | BDBM50286441 ((S)-2-((S)-2-Acetylamino-4-(S)-methyl-pentanoylami...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 8.20 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Medical University of Bialystok | Assay Description Buffer and 0.1 mL of enzyme solution was added to 0.2 mL of examined compounddissolved in 0.15 M NaCl (as control 0.15 M NaCl). The buffer and the en... | J Enzyme Inhib Med Chem 28: 639-43 (2013) Article DOI: 10.3109/14756366.2011.651463 BindingDB Entry DOI: 10.7270/Q2HQ3XTK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin B (Capra hircus (Goat)) | BDBM50286441 ((S)-2-((S)-2-Acetylamino-4-(S)-methyl-pentanoylami...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kurukshetra University Curated by ChEMBL | Assay Description Competitive inhibition of goat brain cathepsin B | Bioorg Med Chem 22: 4233-45 (2014) Article DOI: 10.1016/j.bmc.2014.05.037 BindingDB Entry DOI: 10.7270/Q25Q4XQH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine protease hepsin (Homo sapiens (Human)) | BDBM50286441 ((S)-2-((S)-2-Acetylamino-4-(S)-methyl-pentanoylami...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 61 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University School of Medicine Curated by ChEMBL | Assay Description Inhibition of recombinant hepsin (unknown origin) using Boc-QAR-AMC as substrate by fluorescence assay | ACS Med Chem Lett 5: 1219-24 (2014) Article DOI: 10.1021/ml500254r BindingDB Entry DOI: 10.7270/Q2VM4DV8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor activator (Homo sapiens (Human)) | BDBM50286441 ((S)-2-((S)-2-Acetylamino-4-(S)-methyl-pentanoylami...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 188 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University School of Medicine Curated by ChEMBL | Assay Description Inhibition of recombinant HGFA (unknown origin) using Boc-QLR-AMC as substrate by chromogenic proteolytic assay | ACS Med Chem Lett 5: 1219-24 (2014) Article DOI: 10.1021/ml500254r BindingDB Entry DOI: 10.7270/Q2VM4DV8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Suppressor of tumorigenicity 14 protein (Homo sapiens (Human)) | BDBM50286441 ((S)-2-((S)-2-Acetylamino-4-(S)-methyl-pentanoylami...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 696 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University School of Medicine Curated by ChEMBL | Assay Description Inhibition of matriptase (unknown origin) using Boc-QAR-AMC as substrate by fluorescence assay | ACS Med Chem Lett 5: 1219-24 (2014) Article DOI: 10.1021/ml500254r BindingDB Entry DOI: 10.7270/Q2VM4DV8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Suppressor of tumorigenicity 14 protein (Homo sapiens (Human)) | BDBM50286441 ((S)-2-((S)-2-Acetylamino-4-(S)-methyl-pentanoylami...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn Curated by ChEMBL | Assay Description Inhibition of human recombinant matriptase catalytic domain expressed in HEK293 cells after 20 mins | J Med Chem 53: 5523-35 (2010) Article DOI: 10.1021/jm100183e BindingDB Entry DOI: 10.7270/Q25B02PD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transmembrane protease serine 6 (Homo sapiens (Human)) | BDBM50286441 ((S)-2-((S)-2-Acetylamino-4-(S)-methyl-pentanoylami...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn Curated by ChEMBL | Assay Description Inhibition of human recombinant matriptase 2 expressed in HEK293 cells in conditioned medium after 20 mins | J Med Chem 53: 5523-35 (2010) Article DOI: 10.1021/jm100183e BindingDB Entry DOI: 10.7270/Q25B02PD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transmembrane protease serine 6 (Homo sapiens (Human)) | BDBM50286441 ((S)-2-((S)-2-Acetylamino-4-(S)-methyl-pentanoylami...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 4.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn Curated by ChEMBL | Assay Description Inhibition of human purified matriptase 2 catalytic domain expressed in HEK293 cells after 20 mins | J Med Chem 53: 5523-35 (2010) Article DOI: 10.1021/jm100183e BindingDB Entry DOI: 10.7270/Q25B02PD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pro-cathepsin H (Homo sapiens (Human)) | BDBM50286441 ((S)-2-((S)-2-Acetylamino-4-(S)-methyl-pentanoylami...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 9.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kurukshetra University Curated by ChEMBL | Assay Description Inhibition of human liver cathepsin H | Eur J Med Chem 77: 231-42 (2014) Article DOI: 10.1016/j.ejmech.2014.03.007 BindingDB Entry DOI: 10.7270/Q2319XDV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pro-cathepsin H (Homo sapiens (Human)) | BDBM50286441 ((S)-2-((S)-2-Acetylamino-4-(S)-methyl-pentanoylami...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 9.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kurukshetra University Curated by ChEMBL | Assay Description Inhibition of human liver cathepsin H | Bioorg Med Chem 22: 4233-45 (2014) Article DOI: 10.1016/j.bmc.2014.05.037 BindingDB Entry DOI: 10.7270/Q25Q4XQH | |||||||||||
More data for this Ligand-Target Pair |