Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Adenosylhomocysteinase (Homo sapiens (Human)) | BDBM50331791 ((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 410 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Brigham Young University Curated by ChEMBL | Assay Description Inhibition of S-adenosyl-L-homocysteine hydrolase, inactivation rate constant. | J Med Chem 39: 4162-6 (1996) Article DOI: 10.1021/jm960313y BindingDB Entry DOI: 10.7270/Q2DN45QW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma intracellular receptor 2 (Homo sapiens (Human)) | BDBM50331791 ((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydr...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 796 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical College of Wisconsin Curated by ChEMBL | Assay Description Inhibition of sigma receptor 2 (unknown origin) | J Med Chem 62: 1502-1522 (2019) Article DOI: 10.1021/acs.jmedchem.8b01662 BindingDB Entry DOI: 10.7270/Q2TM7FGK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human)) | BDBM50331791 ((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydr...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 1.48E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical College of Wisconsin Curated by ChEMBL | Assay Description Inhibition of sigma receptor 1 (unknown origin) | J Med Chem 62: 1502-1522 (2019) Article DOI: 10.1021/acs.jmedchem.8b01662 BindingDB Entry DOI: 10.7270/Q2TM7FGK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-alpha (Homo sapiens (Human)) | BDBM50331791 ((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | >3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of FITC-geldanamycin from HSP90alpha (unknown origin) after 24 hrs by fluorescence polarization assay | Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00509 BindingDB Entry DOI: 10.7270/Q280567M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endoplasmin (Homo sapiens (Human)) | BDBM50331791 ((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydr...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of FITC-geldanamycin from GRP94 (unknown origin) after 24 hrs by fluorescence polarization assay | Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00509 BindingDB Entry DOI: 10.7270/Q280567M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribonuclease pancreatic (Bison bison (American bison)) | BDBM50331791 ((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydr...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 6.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Technology Curated by ChEMBL | Assay Description Competitive inhibition of bovine pancreatic RNase A ribonucleolytic activity of by Dixon plot analysis | Bioorg Med Chem 18: 8257-63 (2010) Article DOI: 10.1016/j.bmc.2010.10.005 BindingDB Entry DOI: 10.7270/Q22807V3 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) |