Found 5 hits of ki for monomerid = 50394844 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50394844
(CHEMBL2165019 | US8772480, 224)Show SMILES COc1ccc(Nc2ncc(CN3CCC(CC3)S(C)(=O)=O)cc2-c2nc(C)nc(N)n2)cn1 Show InChI InChI=1S/C22H28N8O3S/c1-14-26-21(29-22(23)27-14)18-10-15(13-30-8-6-17(7-9-30)34(3,31)32)11-25-20(18)28-16-4-5-19(33-2)24-12-16/h4-5,10-12,17H,6-9,13H2,1-3H3,(H,25,28)(H2,23,26,27,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human N-terminal poly-His tagged-PI3Kdelta expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assa... |
J Med Chem 55: 5188-219 (2012)
Article DOI: 10.1021/jm300184s
BindingDB Entry DOI: 10.7270/Q23F4QSJ |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50394844
(CHEMBL2165019 | US8772480, 224)Show SMILES COc1ccc(Nc2ncc(CN3CCC(CC3)S(C)(=O)=O)cc2-c2nc(C)nc(N)n2)cn1 Show InChI InChI=1S/C22H28N8O3S/c1-14-26-21(29-22(23)27-14)18-10-15(13-30-8-6-17(7-9-30)34(3,31)32)11-25-20(18)28-16-4-5-19(33-2)24-12-16/h4-5,10-12,17H,6-9,13H2,1-3H3,(H,25,28)(H2,23,26,27,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human N-terminal poly-His tagged-PI3Kbeta expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assay |
J Med Chem 55: 5188-219 (2012)
Article DOI: 10.1021/jm300184s
BindingDB Entry DOI: 10.7270/Q23F4QSJ |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50394844
(CHEMBL2165019 | US8772480, 224)Show SMILES COc1ccc(Nc2ncc(CN3CCC(CC3)S(C)(=O)=O)cc2-c2nc(C)nc(N)n2)cn1 Show InChI InChI=1S/C22H28N8O3S/c1-14-26-21(29-22(23)27-14)18-10-15(13-30-8-6-17(7-9-30)34(3,31)32)11-25-20(18)28-16-4-5-19(33-2)24-12-16/h4-5,10-12,17H,6-9,13H2,1-3H3,(H,25,28)(H2,23,26,27,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human N-terminal poly-His tagged-PI3Kgamma expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assa... |
J Med Chem 55: 5188-219 (2012)
Article DOI: 10.1021/jm300184s
BindingDB Entry DOI: 10.7270/Q23F4QSJ |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50394844
(CHEMBL2165019 | US8772480, 224)Show SMILES COc1ccc(Nc2ncc(CN3CCC(CC3)S(C)(=O)=O)cc2-c2nc(C)nc(N)n2)cn1 Show InChI InChI=1S/C22H28N8O3S/c1-14-26-21(29-22(23)27-14)18-10-15(13-30-8-6-17(7-9-30)34(3,31)32)11-25-20(18)28-16-4-5-19(33-2)24-12-16/h4-5,10-12,17H,6-9,13H2,1-3H3,(H,25,28)(H2,23,26,27,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| US Patent
| 22 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kalpha, PI3Kbeta, PI... |
US Patent US8772480 (2014)
BindingDB Entry DOI: 10.7270/Q2V123FJ |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50394844
(CHEMBL2165019 | US8772480, 224)Show SMILES COc1ccc(Nc2ncc(CN3CCC(CC3)S(C)(=O)=O)cc2-c2nc(C)nc(N)n2)cn1 Show InChI InChI=1S/C22H28N8O3S/c1-14-26-21(29-22(23)27-14)18-10-15(13-30-8-6-17(7-9-30)34(3,31)32)11-25-20(18)28-16-4-5-19(33-2)24-12-16/h4-5,10-12,17H,6-9,13H2,1-3H3,(H,25,28)(H2,23,26,27,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 22 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human N-terminal poly-His tagged-PI3Kalpha expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assa... |
J Med Chem 55: 5188-219 (2012)
Article DOI: 10.1021/jm300184s
BindingDB Entry DOI: 10.7270/Q23F4QSJ |
More data for this
Ligand-Target Pair | |
Search and Browse
