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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Homo sapiens (Human)) | BDBM50428081 (CHEMBL2323570 | US9303017, (S)-17) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet  | CHEMBL PC cid PC sid UniChem Similars | US Patent | 4.30 | -44.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 4 |
Georgetown University; Duke University US Patent | Assay Description Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris.... | US Patent US9303017 (2016) BindingDB Entry DOI: 10.7270/Q25X27SF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Homo sapiens (Human)) | BDBM50428081 (CHEMBL2323570 | US9303017, (S)-17) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | 4.30 | -44.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 4 |
Georgetown University; Duke University US Patent | Assay Description Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris.... | US Patent US9303017 (2016) BindingDB Entry DOI: 10.7270/Q25X27SF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neuronal acetylcholine receptor subunit alpha-2/beta-2 (Rattus norvegicus (Rat)) | BDBM50428081 (CHEMBL2323570 | US9303017, (S)-17) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | 5.30 | -43.9 | n/a | n/a | n/a | n/a | n/a | 7.4 | 4 |
Georgetown University; Duke University US Patent | Assay Description Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris.... | US Patent US9303017 (2016) BindingDB Entry DOI: 10.7270/Q25X27SF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neuronal acetylcholine receptor subunit alpha-3/beta-2 (Rattus norvegicus (Rat)) | BDBM50428081 (CHEMBL2323570 | US9303017, (S)-17) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | 220 | -35.3 | n/a | n/a | n/a | n/a | n/a | 7.4 | 4 |
Georgetown University; Duke University US Patent | Assay Description Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris.... | US Patent US9303017 (2016) BindingDB Entry DOI: 10.7270/Q25X27SF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neuronal acetylcholine receptor subunit alpha-4/beta-4 (Rattus norvegicus (Rat)) | BDBM50428081 (CHEMBL2323570 | US9303017, (S)-17) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | 3.30E+3 | -29.1 | n/a | n/a | n/a | n/a | n/a | 7.4 | 4 |
Georgetown University; Duke University US Patent | Assay Description Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris.... | US Patent US9303017 (2016) BindingDB Entry DOI: 10.7270/Q25X27SF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neuronal acetylcholine receptor subunit alpha-2/beta-4 (Rattus norvegicus (Rat)) | BDBM50428081 (CHEMBL2323570 | US9303017, (S)-17) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | 2.60E+4 | -24.3 | n/a | n/a | n/a | n/a | n/a | 7.4 | 4 |
Georgetown University; Duke University US Patent | Assay Description Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris.... | US Patent US9303017 (2016) BindingDB Entry DOI: 10.7270/Q25X27SF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat)) | BDBM50428081 (CHEMBL2323570 | US9303017, (S)-17) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.70E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Georgetown University Medical Center Curated by ChEMBL | Assay Description Displacement of [3H]-Epibatidine from rat alpha7 nACHR expressed in HEK293 cell membranes membranes by liquid scintillation counting analysis | J Med Chem 56: 3000-11 (2013) Article DOI: 10.1021/jm4000374 BindingDB Entry DOI: 10.7270/Q21Z45R1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat)) | BDBM50428081 (CHEMBL2323570 | US9303017, (S)-17) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | 1.70E+5 | -20.0 | n/a | n/a | n/a | n/a | n/a | 7.4 | 4 |
Georgetown University; Duke University US Patent | Assay Description Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris.... | US Patent US9303017 (2016) BindingDB Entry DOI: 10.7270/Q25X27SF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat)) | BDBM50428081 (CHEMBL2323570 | US9303017, (S)-17) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | 1.70E+5 | -20.0 | n/a | n/a | n/a | n/a | n/a | 7.4 | 4 |
Georgetown University; Duke University US Patent | Assay Description Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris.... | US Patent US9303017 (2016) BindingDB Entry DOI: 10.7270/Q25X27SF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Rattus norvegicus (Rat)) | BDBM50428081 (CHEMBL2323570 | US9303017, (S)-17) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | 2.50E+5 | -19.1 | n/a | n/a | n/a | n/a | n/a | 7.4 | 4 |
Georgetown University; Duke University US Patent | Assay Description Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris.... | US Patent US9303017 (2016) BindingDB Entry DOI: 10.7270/Q25X27SF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Rattus norvegicus (Rat)) | BDBM50428081 (CHEMBL2323570 | US9303017, (S)-17) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | 3.00E+5 | -18.7 | n/a | n/a | n/a | n/a | n/a | 7.4 | 4 |
Georgetown University; Duke University US Patent | Assay Description Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris.... | US Patent US9303017 (2016) BindingDB Entry DOI: 10.7270/Q25X27SF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
