Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50443085 (AFQ056 | Mavoglurant) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 5.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University Curated by ChEMBL | Assay Description Displacement of [3H]-M-MPEP from mGluR5 StaR domain (569 to 836 residues) (unknown origin) expressed in HEK293 cell membranes | Bioorg Med Chem Lett 26: 484-94 (2016) Article DOI: 10.1016/j.bmcl.2015.11.087 BindingDB Entry DOI: 10.7270/Q21C1ZQ3 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50443085 (AFQ056 | Mavoglurant) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Heptares Therapeutics Ltd. Curated by ChEMBL | Assay Description Displacement of [3H]-M-MPEP from human mGlu5 receptor expressed in HEK293 cells after 90 mins by scintillation spectroscopy analysis | J Med Chem 58: 6653-64 (2015) Article DOI: 10.1021/acs.jmedchem.5b00892 BindingDB Entry DOI: 10.7270/Q2H70HMZ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |