Found 11 hits of ki for monomerid = 9460 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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Similars
| DrugBank PubMed
| 470 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CIBA-GEIGY Corporation
Curated by ChEMBL
| Assay Description Competitive inhibition of human placental Cytochrome P450 19A1 |
J Med Chem 34: 725-36 (1991)
BindingDB Entry DOI: 10.7270/Q2SB46BP |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank PubMed
| 600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johns Hopkins University School of Medicine
Curated by ChEMBL
| Assay Description Binding affinity was measured on Cytochrome P450 19A1 |
J Med Chem 33: 2933-42 (1990)
BindingDB Entry DOI: 10.7270/Q2VM4CW9 |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem
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| DrugBank PubMed
| 600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory constant (Ki) for Cytochrome P450 19A1 |
J Med Chem 28: 200-4 (1985)
BindingDB Entry DOI: 10.7270/Q2WM1FK8 |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem
Patents
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| DrugBank PubMed
| 600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity against human placental cytochrome P450 19A1 |
J Med Chem 30: 1550-4 (1987)
BindingDB Entry DOI: 10.7270/Q2GM869Q |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem
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| DrugBank PubMed
| 680 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Cytochrome P450 19A1 against testosterone at 1.5 uM (Km=0.13 uM) |
J Med Chem 29: 520-3 (1986)
BindingDB Entry DOI: 10.7270/Q28051MG |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank Article PubMed
| 1.41E+3 | -34.7 | 2.80E+3 | n/a | n/a | n/a | n/a | 7.0 | 37 |
Ohio State University
| Assay Description Inhibition of human placental aromatase was determined by monitoring the amount of 3H2O released as the enzyme converts [1beta-3H]androst-4-ene-3,17-... |
J Med Chem 47: 4032-40 (2004)
Article DOI: 10.1021/jm0306024 BindingDB Entry DOI: 10.7270/Q2RJ4GP7 |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank Article PubMed
| 1.41E+3 | -34.7 | 2.80E+3 | n/a | n/a | n/a | n/a | 7.0 | 37 |
Ohio State University
| Assay Description Inhibition of human placental aromatase was determined by monitoring the amount of 3H2O released as the enzyme converts [1beta-3H]androst-4-ene-3,17-... |
Bioorg Med Chem 13: 6571-7 (2005)
Article DOI: 10.1016/j.bmc.2005.07.038 BindingDB Entry DOI: 10.7270/Q2PK0DCK |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem
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| DrugBank Article PubMed
| 1.41E+3 | -34.7 | 2.80E+3 | n/a | n/a | n/a | n/a | 7.0 | 37 |
Ohio State University
| Assay Description Inhibition of human placental aromatase was determined by monitoring the amount of 3H2O released as the enzyme converts [1beta-3H]androst-4-ene-3,17-... |
Bioorg Med Chem 13: 4063-70 (2005)
Article DOI: 10.1016/j.bmc.2005.03.050 BindingDB Entry DOI: 10.7270/Q2TB154R |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem
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| DrugBank PubMed
| 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of human placental cytochrome P450 19A1 with androstenedione |
J Med Chem 30: 1550-4 (1987)
BindingDB Entry DOI: 10.7270/Q2GM869Q |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank PubMed
| 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description Inhibition of human placental cytochrome P450 19A1 with testosterone |
J Med Chem 31: 971-6 (1988)
BindingDB Entry DOI: 10.7270/Q2154J7X |
More data for this Ligand-Target Pair | |
Aromatase
(Homo sapiens (Human)) | BDBM9460
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem
Patents
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| DrugBank Article PubMed
| 4.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The M. S. University of Baroda
Curated by ChEMBL
| Assay Description Inhibition of human aromatase extracted from placental microsomes using [1,2-3H]androstenedione as substrate after 30 mins |
Eur J Med Chem 105: 1-38 (2015)
Article DOI: 10.1016/j.ejmech.2015.09.038 BindingDB Entry DOI: 10.7270/Q2W66NMZ |
More data for this Ligand-Target Pair | |