Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = '11-beta-hydroxysteroid dehydrogenase 1' and Ligand = 'BDBM28367'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM28367 (N-[4-(2-cyano-2,2-dimethylethyl)cyclohexyl]-N-cycl...) Show SMILES CC(C)(C[C@H]1CC[C@@H](CC1)N(C1CC1)C(=O)c1ccc(cc1)[C@](C)(O)C(F)(F)F)C#N |r,wU:7.10,22.25,wD:4.3,22.26,(1.07,2.84,;1.84,1.51,;2.61,2.84,;.51,.73,;-.82,1.5,;-.82,3.05,;-2.16,3.82,;-3.49,3.05,;-3.49,1.5,;-2.16,.73,;-4.83,3.82,;-4.83,5.36,;-5.57,6.7,;-4.03,6.67,;-6.16,3.05,;-6.16,1.51,;-7.49,3.81,;-8.83,3.04,;-10.16,3.81,;-10.16,5.36,;-8.83,6.13,;-7.49,5.36,;-11.49,6.13,;-12.83,5.36,;-12.98,6.52,;-11.49,7.67,;-10.16,8.44,;-12.83,8.44,;-11.49,9.21,;3.18,.74,;4.51,-.03,)| Show InChI InChI=1S/C24H31F3N2O2/c1-22(2,15-28)14-16-4-10-19(11-5-16)29(20-12-13-20)21(30)17-6-8-18(9-7-17)23(3,31)24(25,26)27/h6-9,16,19-20,31H,4-5,10-14H2,1-3H3/t16-,19-,23-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.880	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...				Bioorg Med Chem Lett 19: 1797-801 (2009) Article DOI: 10.1016/j.bmcl.2009.01.058 BindingDB Entry DOI: 10.7270/Q2FB5180
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