Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = '11-beta-hydroxysteroid dehydrogenase 1' and Ligand = 'BDBM50018813'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Rattus norvegicus (rat))	BDBM50018813 (CHEMBL3291349) Show SMILES [H][C@@]12CC[C@@](C)(c3c1c(=O)n(-c1c(Cl)cccc1Cl)n3C)C2(C)C |r,wU:4.4,1.0,(15.18,-8.38,;15.18,-6.88,;16.48,-6.13,;16.48,-4.64,;15.18,-3.89,;14.76,-2.45,;13.89,-4.64,;13.89,-6.13,;12.47,-6.6,;12.01,-8.01,;11.59,-5.39,;10.05,-5.38,;9.29,-4.05,;10.06,-2.71,;7.74,-4.04,;6.97,-5.38,;7.75,-6.72,;9.29,-6.72,;10.06,-8.06,;12.47,-4.18,;11.99,-2.71,;16.05,-5.38,;17.54,-6.24,;17.54,-4.52,)| Show InChI InChI=1S/C18H20Cl2N2O/c1-17(2)10-8-9-18(17,3)15-13(10)16(23)22(21(15)4)14-11(19)6-5-7-12(14)20/h5-7,10H,8-9H2,1-4H3/t10-,18+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. Curated by ChEMBL					Assay Description Inhibition of rat 11betaHSD1 assessed as reduction of cortisone to cortisol by ELISA				Bioorg Med Chem Lett 24: 2707-11 (2014) Article DOI: 10.1016/j.bmcl.2014.04.049 BindingDB Entry DOI: 10.7270/Q2TM7CPF
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50018813 (CHEMBL3291349) Show SMILES [H][C@@]12CC[C@@](C)(c3c1c(=O)n(-c1c(Cl)cccc1Cl)n3C)C2(C)C |r,wU:4.4,1.0,(15.18,-8.38,;15.18,-6.88,;16.48,-6.13,;16.48,-4.64,;15.18,-3.89,;14.76,-2.45,;13.89,-4.64,;13.89,-6.13,;12.47,-6.6,;12.01,-8.01,;11.59,-5.39,;10.05,-5.38,;9.29,-4.05,;10.06,-2.71,;7.74,-4.04,;6.97,-5.38,;7.75,-6.72,;9.29,-6.72,;10.06,-8.06,;12.47,-4.18,;11.99,-2.71,;16.05,-5.38,;17.54,-6.24,;17.54,-4.52,)| Show InChI InChI=1S/C18H20Cl2N2O/c1-17(2)10-8-9-18(17,3)15-13(10)16(23)22(21(15)4)14-11(19)6-5-7-12(14)20/h5-7,10H,8-9H2,1-4H3/t10-,18+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. Curated by ChEMBL					Assay Description Inhibition of full-length human 11betaHSD1 expressed in HEK293 cells assessed as cortisol level by competitive ELISA				Bioorg Med Chem Lett 24: 2707-11 (2014) Article DOI: 10.1016/j.bmcl.2014.04.049 BindingDB Entry DOI: 10.7270/Q2TM7CPF
					More data for this Ligand-Target Pair