Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
11-beta-hydroxysteroid dehydrogenase 1 (Rattus norvegicus (rat)) | BDBM50067040 (((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-hept...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 3.92E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wenzhou Medical College Curated by ChEMBL | Assay Description Inhibition of 11beta-HSD1 in Sprague-Dawley rat leydig cells at 100 uM | Bioorg Med Chem Lett 23: 4362-6 (2013) Article DOI: 10.1016/j.bmcl.2013.05.080 BindingDB Entry DOI: 10.7270/Q27D2WJM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Rattus norvegicus (rat)) | BDBM50067040 (((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-hept...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 4.13E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wenzhou Medical College Curated by ChEMBL | Assay Description Inhibition of 11beta-HSD1 in rat testis microsomes using [3H]-11-DHC as substrate assessed as formation of CORT after 60 to 90 mins by radiometric an... | Bioorg Med Chem Lett 23: 4362-6 (2013) Article DOI: 10.1016/j.bmcl.2013.05.080 BindingDB Entry DOI: 10.7270/Q27D2WJM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50067040 (((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-hept...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wenzhou Medical College Curated by ChEMBL | Assay Description Inhibition of human 11beta-HSD1 transfected in CHOP cells | Bioorg Med Chem Lett 23: 4362-6 (2013) Article DOI: 10.1016/j.bmcl.2013.05.080 BindingDB Entry DOI: 10.7270/Q27D2WJM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50067040 (((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-hept...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wenzhou Medical College Curated by ChEMBL | Assay Description Inhibition of 11beta-HSD1 in human liver microsomes using [3H]-cortisone as substrate assessed as formation of cortisol after 60 to 90 mins by radiom... | Bioorg Med Chem Lett 23: 4362-6 (2013) Article DOI: 10.1016/j.bmcl.2013.05.080 BindingDB Entry DOI: 10.7270/Q27D2WJM | |||||||||||
More data for this Ligand-Target Pair |