Found 3 hits Enz. Inhib. hit(s) with Target = '11-beta-hydroxysteroid dehydrogenase 1' and Ligand = 'BDBM50202104' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50202104
((E)-N-(5-methoxy-adamantan-2-yl)-2-[4-(5-trifluoro...)Show SMILES CO[C@@]12CC3CC(C1)[C@H](NC(=O)C(C)N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(C3)C2 |r,wU:8.9,wD:2.1,TLB:5:4:32:7.6.8,5:6:3.4.31:32,THB:8:6:3:31.30.32,8:30:3:7.5.6,9:8:3.4.31:32,(-11.76,-8.87,;-10.48,-7.77,;-8.89,-8.33,;-10.15,-9.55,;-8.63,-9.2,;-7.25,-9.82,;-6.18,-8.59,;-7.59,-8.88,;-6.1,-7.07,;-4.78,-6.27,;-3.43,-7.02,;-3.41,-8.56,;-2.11,-6.23,;-2.14,-4.69,;-.77,-6.98,;-.78,-8.53,;.54,-9.3,;1.88,-8.54,;1.89,-6.99,;.55,-6.21,;3.18,-9.36,;3.11,-10.9,;4.41,-11.72,;5.78,-11.01,;5.84,-9.47,;4.54,-8.65,;7.08,-11.84,;8.38,-12.64,;6.26,-13.14,;7.9,-10.54,;-7.47,-6.43,;-8.56,-7.61,;-8.84,-6.84,)| Show InChI InChI=1S/C24H33F3N4O2/c1-15(22(32)29-21-17-9-16-10-18(21)13-23(11-16,12-17)33-2)30-5-7-31(8-6-30)20-4-3-19(14-28-20)24(25,26)27/h3-4,14-18,21H,5-13H2,1-2H3,(H,29,32)/t15?,16?,17?,18?,21-,23- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 expressed in E. coli by SPA |
J Med Chem 50: 149-64 (2007)
Article DOI: 10.1021/jm0609364
BindingDB Entry DOI: 10.7270/Q2Z60NQN |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Mus musculus (mouse)) | BDBM50202104
((E)-N-(5-methoxy-adamantan-2-yl)-2-[4-(5-trifluoro...)Show SMILES CO[C@@]12CC3CC(C1)[C@H](NC(=O)C(C)N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(C3)C2 |r,wU:8.9,wD:2.1,TLB:5:4:32:7.6.8,5:6:3.4.31:32,THB:8:6:3:31.30.32,8:30:3:7.5.6,9:8:3.4.31:32,(-11.76,-8.87,;-10.48,-7.77,;-8.89,-8.33,;-10.15,-9.55,;-8.63,-9.2,;-7.25,-9.82,;-6.18,-8.59,;-7.59,-8.88,;-6.1,-7.07,;-4.78,-6.27,;-3.43,-7.02,;-3.41,-8.56,;-2.11,-6.23,;-2.14,-4.69,;-.77,-6.98,;-.78,-8.53,;.54,-9.3,;1.88,-8.54,;1.89,-6.99,;.55,-6.21,;3.18,-9.36,;3.11,-10.9,;4.41,-11.72,;5.78,-11.01,;5.84,-9.47,;4.54,-8.65,;7.08,-11.84,;8.38,-12.64,;6.26,-13.14,;7.9,-10.54,;-7.47,-6.43,;-8.56,-7.61,;-8.84,-6.84,)| Show InChI InChI=1S/C24H33F3N4O2/c1-15(22(32)29-21-17-9-16-10-18(21)13-23(11-16,12-17)33-2)30-5-7-31(8-6-30)20-4-3-19(14-28-20)24(25,26)27/h3-4,14-18,21H,5-13H2,1-2H3,(H,29,32)/t15?,16?,17?,18?,21-,23- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of mouse 11beta-HSD1 expressed in E. coli by SPA |
J Med Chem 50: 149-64 (2007)
Article DOI: 10.1021/jm0609364
BindingDB Entry DOI: 10.7270/Q2Z60NQN |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50202104
((E)-N-(5-methoxy-adamantan-2-yl)-2-[4-(5-trifluoro...)Show SMILES CO[C@@]12CC3CC(C1)[C@H](NC(=O)C(C)N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(C3)C2 |r,wU:8.9,wD:2.1,TLB:5:4:32:7.6.8,5:6:3.4.31:32,THB:8:6:3:31.30.32,8:30:3:7.5.6,9:8:3.4.31:32,(-11.76,-8.87,;-10.48,-7.77,;-8.89,-8.33,;-10.15,-9.55,;-8.63,-9.2,;-7.25,-9.82,;-6.18,-8.59,;-7.59,-8.88,;-6.1,-7.07,;-4.78,-6.27,;-3.43,-7.02,;-3.41,-8.56,;-2.11,-6.23,;-2.14,-4.69,;-.77,-6.98,;-.78,-8.53,;.54,-9.3,;1.88,-8.54,;1.89,-6.99,;.55,-6.21,;3.18,-9.36,;3.11,-10.9,;4.41,-11.72,;5.78,-11.01,;5.84,-9.47,;4.54,-8.65,;7.08,-11.84,;8.38,-12.64,;6.26,-13.14,;7.9,-10.54,;-7.47,-6.43,;-8.56,-7.61,;-8.84,-6.84,)| Show InChI InChI=1S/C24H33F3N4O2/c1-15(22(32)29-21-17-9-16-10-18(21)13-23(11-16,12-17)33-2)30-5-7-31(8-6-30)20-4-3-19(14-28-20)24(25,26)27/h3-4,14-18,21H,5-13H2,1-2H3,(H,29,32)/t15?,16?,17?,18?,21-,23- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 expressed in HEK293 cells by FPIA |
J Med Chem 50: 149-64 (2007)
Article DOI: 10.1021/jm0609364
BindingDB Entry DOI: 10.7270/Q2Z60NQN |
More data for this
Ligand-Target Pair | |
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