Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50248133 (CHEMBL518644 | N-((1s,4R)-4-cyano-4-cyclopropylcyc...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of FLAG-tagged full length human 11beta-HSD1 expressed in baculovirus-infected Trichoplusia ni Hi5 cells assessed as reduction of [3H]cort... | Bioorg Med Chem Lett 19: 1446-50 (2009) Article DOI: 10.1016/j.bmcl.2009.01.026 BindingDB Entry DOI: 10.7270/Q2TD9Z8S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50248133 (CHEMBL518644 | N-((1s,4R)-4-cyano-4-cyclopropylcyc...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of full length human recombinant 11beta-HSD1 expressed in HEK293 cells in absence of NADPH | Bioorg Med Chem Lett 19: 1446-50 (2009) Article DOI: 10.1016/j.bmcl.2009.01.026 BindingDB Entry DOI: 10.7270/Q2TD9Z8S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50248133 (CHEMBL518644 | N-((1s,4R)-4-cyano-4-cyclopropylcyc...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. Curated by ChEMBL | Assay Description Inhibition of full length human recombinant 11beta-HSD1 expressed in HEK293 cells in presence of 3% human serum albumin | Bioorg Med Chem Lett 19: 1446-50 (2009) Article DOI: 10.1016/j.bmcl.2009.01.026 BindingDB Entry DOI: 10.7270/Q2TD9Z8S | |||||||||||
More data for this Ligand-Target Pair |