Found 2 hits Enz. Inhib. hit(s) with Target = '11-beta-hydroxysteroid dehydrogenase 1' and Ligand = 'BDBM50334706' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50334706
(3-(Toluene-4-sulfonyl)-thiazolidine-2-carboxylic a...)Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCSC1C(=O)NC1C2CC3CC1CC(C3)(C2)C(N)=O |TLB:17:18:24.27.25:20.21.22,17:18:22:24.25.26,27:25:18.19.20:22,THB:27:19:22:24.25.26,26:25:18:20.21.22,26:21:18:24.27.25,28:25:18:20.21.22,28:25:18.19.20:22,(21.54,-45.78,;22.86,-44.98,;22.84,-43.44,;24.16,-42.65,;25.5,-43.41,;25.53,-44.94,;24.21,-45.73,;26.82,-42.62,;26.04,-41.28,;27.58,-41.28,;28.17,-43.37,;28.64,-44.83,;30.18,-44.83,;30.66,-43.37,;29.41,-42.46,;29.41,-40.92,;28.07,-40.15,;30.74,-40.15,;32.07,-40.91,;33.57,-40.49,;33.57,-38.91,;34.61,-37.68,;33.26,-38.15,;33.27,-39.64,;34.6,-40.13,;35.99,-39.78,;36,-38.25,;34.98,-41.06,;37.53,-39.72,;38.35,-41.02,;38.25,-38.36,)| Show InChI InChI=1S/C22H29N3O4S2/c1-13-2-4-17(5-3-13)31(28,29)25-6-7-30-20(25)19(26)24-18-15-8-14-9-16(18)12-22(10-14,11-15)21(23)27/h2-5,14-16,18,20H,6-12H2,1H3,(H2,23,27)(H,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assay |
Bioorg Med Chem Lett 21: 435-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.123
BindingDB Entry DOI: 10.7270/Q2FJ2H1K |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Mus musculus (mouse)) | BDBM50334706
(3-(Toluene-4-sulfonyl)-thiazolidine-2-carboxylic a...)Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCSC1C(=O)NC1C2CC3CC1CC(C3)(C2)C(N)=O |TLB:17:18:24.27.25:20.21.22,17:18:22:24.25.26,27:25:18.19.20:22,THB:27:19:22:24.25.26,26:25:18:20.21.22,26:21:18:24.27.25,28:25:18:20.21.22,28:25:18.19.20:22,(21.54,-45.78,;22.86,-44.98,;22.84,-43.44,;24.16,-42.65,;25.5,-43.41,;25.53,-44.94,;24.21,-45.73,;26.82,-42.62,;26.04,-41.28,;27.58,-41.28,;28.17,-43.37,;28.64,-44.83,;30.18,-44.83,;30.66,-43.37,;29.41,-42.46,;29.41,-40.92,;28.07,-40.15,;30.74,-40.15,;32.07,-40.91,;33.57,-40.49,;33.57,-38.91,;34.61,-37.68,;33.26,-38.15,;33.27,-39.64,;34.6,-40.13,;35.99,-39.78,;36,-38.25,;34.98,-41.06,;37.53,-39.72,;38.35,-41.02,;38.25,-38.36,)| Show InChI InChI=1S/C22H29N3O4S2/c1-13-2-4-17(5-3-13)31(28,29)25-6-7-30-20(25)19(26)24-18-15-8-14-9-16(18)12-22(10-14,11-15)21(23)27/h2-5,14-16,18,20H,6-12H2,1H3,(H2,23,27)(H,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 842 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University
Curated by ChEMBL
| Assay Description
Inhibition of mouse 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assay |
Bioorg Med Chem Lett 21: 435-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.123
BindingDB Entry DOI: 10.7270/Q2FJ2H1K |
More data for this
Ligand-Target Pair | |
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