Found 2 hits Enz. Inhib. hit(s) with Target = '11-beta-hydroxysteroid dehydrogenase 1' and Ligand = 'BDBM50400160' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50400160
(CHEMBL2179442)Show SMILES CC(C)Oc1nc(N[C@@H]2CCOC2)ncc1C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 |r,wU:19.20,wD:26.29,8.7,TLB:27:26:19:23.22.21,18:19:29.25.26:23.22.21,18:19:21:29.26.28,THB:27:26:19.24.23:21,28:26:19:23.22.21,28:22:19:29.25.26,25:24:21:29.26.28,25:26:19.24.23:21,(11.53,-55.4,;10.19,-54.63,;8.86,-55.4,;10.19,-53.09,;8.86,-52.32,;7.52,-53.09,;6.19,-52.32,;4.85,-53.09,;3.52,-52.32,;2.11,-52.94,;1.08,-51.8,;1.85,-50.46,;3.36,-50.79,;6.19,-50.78,;7.52,-50.01,;8.85,-50.77,;10.18,-50,;10.18,-48.46,;11.52,-50.76,;12.85,-49.99,;12.84,-48.24,;11.81,-47.17,;12.46,-45.9,;12.48,-47.34,;13.65,-48.66,;15.06,-48.1,;14.92,-46.47,;16.45,-46.48,;13.88,-45.35,;14.14,-47.69,)| Show InChI InChI=1S/C22H32N4O4/c1-12(2)30-20-17(10-23-21(26-20)24-16-3-4-29-11-16)19(27)25-18-14-5-13-6-15(18)9-22(28,7-13)8-14/h10,12-16,18,28H,3-9,11H2,1-2H3,(H,25,27)(H,23,24,26)/t13?,14?,15?,16-,18-,22-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human 11beta-HSD1 by HTRF assay |
J Med Chem 55: 10652-61 (2012)
Article DOI: 10.1021/jm3013163 BindingDB Entry DOI: 10.7270/Q2BG2Q4S |
More data for this Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Mus musculus (mouse)) | BDBM50400160
(CHEMBL2179442)Show SMILES CC(C)Oc1nc(N[C@@H]2CCOC2)ncc1C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 |r,wU:19.20,wD:26.29,8.7,TLB:27:26:19:23.22.21,18:19:29.25.26:23.22.21,18:19:21:29.26.28,THB:27:26:19.24.23:21,28:26:19:23.22.21,28:22:19:29.25.26,25:24:21:29.26.28,25:26:19.24.23:21,(11.53,-55.4,;10.19,-54.63,;8.86,-55.4,;10.19,-53.09,;8.86,-52.32,;7.52,-53.09,;6.19,-52.32,;4.85,-53.09,;3.52,-52.32,;2.11,-52.94,;1.08,-51.8,;1.85,-50.46,;3.36,-50.79,;6.19,-50.78,;7.52,-50.01,;8.85,-50.77,;10.18,-50,;10.18,-48.46,;11.52,-50.76,;12.85,-49.99,;12.84,-48.24,;11.81,-47.17,;12.46,-45.9,;12.48,-47.34,;13.65,-48.66,;15.06,-48.1,;14.92,-46.47,;16.45,-46.48,;13.88,-45.35,;14.14,-47.69,)| Show InChI InChI=1S/C22H32N4O4/c1-12(2)30-20-17(10-23-21(26-20)24-16-3-4-29-11-16)19(27)25-18-14-5-13-6-15(18)9-22(28,7-13)8-14/h10,12-16,18,28H,3-9,11H2,1-2H3,(H,25,27)(H,23,24,26)/t13?,14?,15?,16-,18-,22-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of mouse 11beta-HSD1 by HTRF assay |
J Med Chem 55: 10652-61 (2012)
Article DOI: 10.1021/jm3013163 BindingDB Entry DOI: 10.7270/Q2BG2Q4S |
More data for this Ligand-Target Pair | |